Protein Alignment Blimp-1 and PRDM1

DIOPT Version :9

• Sequence 1: NP_001261442.1
• Gene: Blimp-1 / 38638
• FlyBaseID: FBgn0035625
• Length: 1216
• Species: Drosophila melanogaster
• Sequence 2: XP_011534364.1
• Gene: PRDM1 / 639
• HGNCID: 9346
• Length: 839
• Species: Homo sapiens
• Alignment Length: 1006
• Identity: 296/1006 - (29%)
• Similarity: 395/1006 - (39%)
• Gaps: 341/1006 - (33%)

  Fly    61 PHHKLSARRARSRSRSRSPTPDGN---------------------QDYDVTRMREEDFERLAVYL 104
            |.| .||.|.::|..|.: .|..|                     :|.|:|...|.:||....|:
Human    13 PEH-FSAMRGKARDCSEA-APKCNSSTVRFQGLAEGTKGTMKMDMEDADMTLWTEAEFEEKCTYI 75

  Fly   105 VP----DVQAERGLPNRADKTLPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTS 165
            |.    |..|:.|...:|:.:|||:|..|    |:|.:.:..||.|...||:||||||..|   .
Human    76 VNDHPWDSGADGGTSVQAEASLPRNLLFK----YATNSEEVIGVMSKEYIPKGTRFGPLIG---E 133

  Fly   166 NYPND---KNKAR-YFWRV--QGTRHITYGNIKIFKDDDYYYLDGSDRSQSNWMRYVASAYSLSV 224
            .|.||   ||..| ||||:  :|..|              :::||.:..:|||||||..|:|...
Human   134 IYTNDTVPKNANRKYFWRIYSRGELH--------------HFIDGFNEEKSNWMRYVNPAHSPRE 184

  Fly   225 MNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPETTIFGACKQAVEAEEEADEE 289
            .||.|||:..||||||.:.|..|:||:||||:|||.||.|....|.|:....:.....::.:.|:
Human   185 QNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGELTMMNLTQTQSSLKQPSTEK 249

  Fly   290 EEEAEGEDGKPRYSMPAPEIPPDVAVSHITYVMGLHLPVGAGNGPANGSVAGSVSGATPPPPTAT 354
            .|.......|..||:  .||                  :...:.|:.|.
Human   250 NELCPKNVPKREYSV--KEI------------------LKLDSNPSKGK---------------- 278

  Fly   355 PCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIGQDRSPMASSDKD-----TAGSPLSGLDH 414
                               :.:..:|              ||: :|:||     ..|||
Human   279 -------------------DLYRSNI--------------SPL-TSEKDLDDFRRRGSP------ 303

  Fly   415 QMTPQDGSVRSVRSDEGYHSNECHEDGLTP-PEDSSDSESEHNYVLDCSKKAIAPKETVIAQAQK 478
            :|......|..:|:               | |||          .|..|......:.|.|.::..
Human   304 EMPFYPRVVYPIRA---------------PLPED----------FLKASLAYGIERPTYITRSPI 343

  Fly   479 PSSSPPAVVMANTTTNSMIS---HSSP--TATPICETDKNEYRKFKVKMPLKYEFKNKTCVKQEP 538
            |||:.|:....::...|:.|   ||||  |.:|: .....|:|.       .|.:.|.:...:
Human   344 PSSTTPSPSARSSPDQSLKSSSPHSSPGNTVSPV-GPGSQEHRD-------SYAYLNASYGTE-- 398

  Fly   539 SLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHLGDEHMLMMERERERERERIQEREPSNQQP 603
            .|........||.          .|.:..||...|
Human   399 GLGSYPGYAPLPH----------LPPAFIPSYNAH------------------------------ 423

  Fly   604 ASSTVIVLEHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSSSILETILTSQHRLEAAAAAAN 668
                          ..:.::|   ||             |...:.:            :|.::.|
Human   424 --------------YPKFLLP---PY-------------GMNCNGL------------SAVSSMN 446

  Fly   669 ACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQNPEQLSSSAVVVGEQEMTRATMI 733
            ...  |....|...|.           |.|.:...|..:...||..|.||....|.:.:.:
Human   447 GIN--NFGLFPRLCPV-----------YSNLLGGGSLPHPMLNPTSLPSSLPSDGARRLLQ---- 494

  Fly   734 KGECSPPPPSHHHHNVIFSPSRHAAYLGAGEAGGHSPSPGYP--GYPHYGAAATSTFHSPPHSSH 796
                    |.|...  :..|:.|:|:...|.|.........|  |.|..|.|||:.....|
Human   495 --------PEHPRE--VLVPAPHSAFSFTGAAASMKDKACSPTSGSPTAGTAATAEHVVQP---- 545

  Fly   797 SPFDRQSNASSGAGSATNLHLLQTSTQMLNHPLMQPLTPLQRLSPLRISPPSSLSPDGNSCPRSG 861
                   .|:|.|.:|      .:|.:.:|
Human   546 -------KATSAAMAA------PSSDEAMN----------------------------------- 562

  Fly   862 SPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQLSNLKVHLRTHSGERPFKCNVCTKS 926
              |..|.....||::|||||||::||:.||||||.||||||||||||||.|||||||||..|.|.
Human   563 --LIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQLSNLKVHLRVHSGERPFKCQTCNKG 625

  Fly   927 FTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLHSGQKPYACDLCPQKFTQFVHLKL 991
            ||||||||||:|||||||||:|.:|.||||||||||||||||||:|||.|.:||.||||||||||
Human   626 FTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLRLHSGEKPYQCKVCPAKFTQFVHLKL 690

  Fly   992 HKRLHTNDRPYVCQGCDKKYISASGLRTHWK 1022
            ||||||.:||:.|..|.|.||....|:.|.|
Human   691 HKRLHTRERPHKCSQCHKNYIHLCSLKVHLK 721

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	58/132 (44%)
		C2H2 Zn finger	892..912	CDD:275368	18/19 (95%)
		zf-H2C2_2	904..929	CDD:290200	19/24 (79%)
		C2H2 Zn finger	920..940	CDD:275368	14/19 (74%)
		zf-H2C2_2	932..957	CDD:290200	19/24 (79%)
		C2H2 Zn finger	948..968	CDD:275368	16/19 (84%)
		zf-H2C2_2	960..985	CDD:290200	19/24 (79%)
		C2H2 Zn finger	976..996	CDD:275368	16/19 (84%)
		C2H2 Zn finger	1004..1023	CDD:275368	8/19 (42%)
PRDM1	XP_011534364.1	SET	114..220	CDD:214614	56/122 (46%)
		COG5048	<584..702	CDD:227381	96/117 (82%)
		zf-C2H2	589..611	CDD:278523	20/21 (95%)
		C2H2 Zn finger	591..611	CDD:275368	18/19 (95%)
		zf-H2C2_2	603..628	CDD:290200	19/24 (79%)
		C2H2 Zn finger	619..639	CDD:275368	14/19 (74%)
		zf-H2C2_2	631..656	CDD:290200	19/24 (79%)
		C2H2 Zn finger	647..667	CDD:275368	16/19 (84%)
		zf-H2C2_2	659..684	CDD:290200	19/24 (79%)
		C2H2 Zn finger	675..695	CDD:275368	16/19 (84%)
		zf-H2C2_2	687..708	CDD:290200	14/20 (70%)
		C2H2 Zn finger	703..721	CDD:275368	7/17 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147266
Domainoid	1	1.000	50	1.000	Domainoid score	I11770
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	393	1.000	Inparanoid score	I1988
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233655at33208
OrthoFinder	1	1.000	-	-		FOG0006205
OrthoInspector	1	1.000	-	-		oto89086
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16515
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4128
SonicParanoid	1	1.000	-	-		X5144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.980