DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Blimp-1 and PRDM9

DIOPT Version :9

Sequence 1:NP_001261442.1 Gene:Blimp-1 / 38638 FlyBaseID:FBgn0035625 Length:1216 Species:Drosophila melanogaster
Sequence 2:NP_001297143.1 Gene:PRDM9 / 56979 HGNCID:13994 Length:894 Species:Homo sapiens


Alignment Length:1044 Identity:223/1044 - (21%)
Similarity:339/1044 - (32%) Gaps:325/1044 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 SGAIMKAANQPHHPAHSHPLNHPHPHQHAQPHPHPHPHPHHKLSARRARSRSRSRSPTPDGNQDY 87
            ||:  :.|.:|..|:.....:..|.....:..........:.|..|:..:......|..|   ||
Human   143 SGS--EQAQKPVSPSGEASTSGQHSRLKLELRKKETERKMYSLRERKGHAYKEVSEPQDD---DY 202

  Fly    88 DVTRMREEDF-ERLAVY----LVPDVQAERGLPNRADKTLPRSLTLKSSMVYSTPNVKTEGVWS- 146
            ....|.:..| :..|.:    .|.|...::|.|||:..:||..|.:..|.:   |.... |||: 
Human   203 LYCEMCQNFFIDSCAAHGPPTFVKDSAVDKGHPNRSALSLPPGLRIGPSGI---PQAGL-GVWNE 263

  Fly   147 SGVIPRGTRFGPFEGIPTSNYPNDKNKAR--YFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQ 209
            :..:|.|..|||:||..|    .|:..|.  |.|.:...|:.            |.|:||.|:|.
Human   264 ASDLPLGLHFGPYEGRIT----EDEEAANNGYSWLITKGRNC------------YEYVDGKDKSW 312

  Fly   210 SNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPETTIFG 274
            :||||||..|......||||.|:...|::.|.|.|.|..||:|||..::...||..       :|
Human   313 ANWMRYVNCARDDEEQNLVAFQYHRQIFYRTCRVIRPGCELLVWYGDEYGQELGIK-------WG 370

  Fly   275 A-CKQAVEAEEEADEEEEEAEGEDGKPRYSMPAPEIPPDVAVSHITYVMGLHLPVGAGNGPANGS 338
            : .|:.:.|..|                   |.|||.|                           
Human   371 SKWKKELMAGRE-------------------PKPEIHP--------------------------- 389

  Fly   339 VAGSVSGATPPPPTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIGQDRSPMASSDKD 403
                          ...||...|....:|          .|::. .|:|     ...|..|:.| 
Human   390 --------------CPSCCLAFSSQKFLS----------QHVER-NHSS-----QNFPGPSARK- 423

  Fly   404 TAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSDSESEHNYVLDCSKKAIAP 468
                       .:.|::........::.|           |...|.:.:::...:.:.||  :..
Human   424 -----------LLQPENPCPGDQNQEQQY-----------PDPHSRNDKTKGQEIKERSK--LLN 464

  Fly   469 KETVIAQAQKPSSSPPAVVMANTTTNSMI-SHSSPTATPICETDKNEYRKFKVKMPLKYEFKNKT 532
            |.|...:..:..||||...|.:......| ...|.|...:   :.....|..|.:.:....|.| 
Human   465 KRTWQREISRAFSSPPKGQMGSCRVGKRIMEEESRTGQKV---NPGNTGKLFVGVGISRIAKVK- 525

  Fly   533 CVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHLGDE---------------HMLMM 582
                   ..|..|..|:    :.|.:.|..         ||.|::               |:|:.
Human   526 -------YGECGQGFSV----KSDVITHQR---------THTGEKLYVCRECGRGFSWKSHLLIH 570

  Fly   583 ERERERERERIQEREPSNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSS 647
            :|....|:..:. ||........|.::..:....|:        |||...: .|..:.|     .
Human   571 QRIHTGEKPYVC-RECGRGFSWQSVLLTHQRTHTGE--------KPYVCRE-CGRGFSR-----Q 620

  Fly   648 SILETILTSQHRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDS------SS 706
            |:|.|     |:..........||:.                       |...|..|      ..
Human   621 SVLLT-----HQRRHTGEKPYVCREC-----------------------GRGFSRQSVLLTHQRR 657

  Fly   707 NLGQNPEQLSSSAVVVGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEAGGHSPS 771
            :.|:.|                   .:..||                       |.|        
Human   658 HTGEKP-------------------YVCREC-----------------------GRG-------- 672

  Fly   772 PGYPGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQMLNHPLMQPLTPL 836
                    :...:....|...|:...|:..:   ..|.|.:....||   |....|...:|..  
Human   673 --------FSWQSVLLSHQRTHTGEKPYVCR---ECGRGFSWQSVLL---THQRTHTGEKPYV-- 721

  Fly   837 QRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQ 901
                                |...|...|..|...|..|:       ..|:..|.|..|.:.|..
Human   722 --------------------CRECGRGFSNKSHLLRHQRT-------HTGEKPYVCRECGRGFRD 759

  Fly   902 LSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLR 966
            .|:|..|.|||:||:|:.|..|.:.|...::|..|...||||||:.|..|.:.||:.|:|..|.|
Human   760 KSHLLRHQRTHTGEKPYVCRECGRGFRDKSNLLSHQRTHTGEKPYVCRECGRGFSNKSHLLRHQR 824

  Fly   967 LHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLRTHWKT-TSCKPNN 1030
            .|:|:|||.|..|.:.|....||..|:|.||.::||||:.|.:.:...|.|..|.:| |..||..
Human   825 THTGEKPYVCRECGRGFRNKSHLLRHQRTHTGEKPYVCRECGRGFSDRSSLCYHQRTHTGEKPYV 889

  Fly  1031 LEEE 1034
            ..|:
Human   890 CRED 893

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Blimp-1NP_001261442.1 SET 133..260 CDD:214614 45/129 (35%)
C2H2 Zn finger 892..912 CDD:275368 7/19 (37%)
zf-H2C2_2 904..929 CDD:290200 11/24 (46%)
C2H2 Zn finger 920..940 CDD:275368 5/19 (26%)
zf-H2C2_2 932..957 CDD:290200 11/24 (46%)
C2H2 Zn finger 948..968 CDD:275368 8/19 (42%)
zf-H2C2_2 960..985 CDD:290200 11/24 (46%)
C2H2 Zn finger 976..996 CDD:275368 7/19 (37%)
C2H2 Zn finger 1004..1023 CDD:275368 5/18 (28%)
PRDM9NP_001297143.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
KRAB 27..85 CDD:214630
KRAB 27..62 CDD:279668
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 143..174 6/32 (19%)
SSXRD 171..201 CDD:286586 4/32 (13%)
SET 246..364 CDD:214614 47/137 (34%)
S-adenosyl-L-methionine binding. /evidence=ECO:0000269|Ref.9 256..258 0/1 (0%)
Substrate binding. /evidence=ECO:0000250|UniProtKB:Q96EQ9 288..294 1/5 (20%)