Protein Alignment Blimp-1 and PRDM8

DIOPT Version :9

• Sequence 1: NP_001261442.1
• Gene: Blimp-1 / 38638
• FlyBaseID: FBgn0035625
• Length: 1216
• Species: Drosophila melanogaster
• Sequence 2: XP_011530435.1
• Gene: PRDM8 / 56978
• HGNCID: 13993
• Length: 970
• Species: Homo sapiens
• Alignment Length: 1047
• Identity: 210/1047 - (20%)
• Similarity: 297/1047 - (28%)
• Gaps: 425/1047 - (40%)

  Fly    33 PHHPAHSHPLNHPHP-HQHAQPHP---HPHPHPH-HKLS-------ARRARSRSRSRSPTPDGNQ 85
            |..|...|||.| || ...:.|.|   .|....| |.|:       .:|..|.:.||
Human   209 PRRPRQLHPLLH-HPLDVKSFPEPILEEPKRRQHQHLLTWKYTDTIGKRKHSIASSR-------- 264

  Fly    86 DYDVTRMREEDFERLAVYLVP---DVQAERGLPNRADKTLPRSLTLKSSMVYSTPNVKTEGVWSS 147
             :.|..     |.|....|:|   |...:||:.:...|.:.:.||...:.||:|.:
Human   265 -FQVAL-----FGRFYTDLIPVMEDTGIQRGIWDGDAKAVQQCLTDIFTSVYTTCD--------- 314

  Fly   148 GVIPRGTRFGPFEGIPTSNYPN---------DKNKARYFWRVQGTRHITYGNIKIFKDDDYYYLD 203
              ||....|||.....||.|.:         ||....|.:||
Human   315 --IPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTVPYIFRV----------------------- 354

  Fly   204 GSDRSQSN-------WMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASR 261
              |.|.:|       |:|.|.||......||.|......:::.:.|.|..:|||:|||.|:.
Human   355 --DTSAANGSSEGLMWLRLVQSARDKEEQNLEAYIKNGQLFYRSLRRIAKDEELLVWYGKEL--- 414

  Fly   262 LGYDVDPETTIFGACKQAVEAEEEADEEEEEAEGEDGKPRYSMPAPEIPPDVAVSHITYVMGLHL 326
                    |.:...|                       |..|                     |.
Human   415 --------TELLLLC-----------------------PSRS---------------------HN 427

  Fly   327 PVGAGNGPANGSVAGSVSGATPPPPTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGR------- 384
            .:.||:.|.                |...|.:|             .....|::.|.|
Human   428 KMNAGSSPY----------------TCLECSQR-------------FQFEFPYVAHLRFRCPKRL 463

  Fly   385 HASVIIGQDRSPMASSDKDTAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSS 449
            |::.|..||........||..|....|.|.|...|:..:       |.....|....|
Human   464 HSADISPQDEQGGGVGTKDHGGGGGGGKDQQQQQQEAPL-------GPGPKFCKAGPL------- 514

  Fly   450 DSESEHNYVLDCSKKAIAPKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTATPICETDKNE 514
                 |:|                     ||.||       .::|...:....:|.|  .||.:.
Human   515 -----HHY---------------------PSPSP-------ESSNPSAAAGGSSAKP--STDFHN 544

  Fly   515 YRKFKVKMPLKYEFKN----KTCVKQEPSLKEVD--------QEMSLPQEEEEDQVMHPEPDSIC 567
                     |..|.:|    .:|...: ||....        ||..|            .||.|.
Human   545 ---------LARELENSRGGSSCSPAQ-SLSSGSGSGGGGGHQEAEL------------SPDGIA 587

  Fly   568 ----------PSTTTHLGDEHMLMMERERERERERIQERE----PSNQQPASSTVIVLEHNSGGQ 618
                      |......|....|:..|.|..||.....:|    ...|..||.:...||.|
Human   588 TGGGKGKRKFPEEAAEGGGGAGLVGGRGRFVERPLPASKEDLVCTPQQYRASGSYFGLEEN---- 648

  Fly   619 ARTIVPLSKPYYEPDPPGERYMRFGQPSSSILETILTSQHRLEAAAAAANACRQANAATPPPTSP 683
            .|...|       |.|......|     |:.:|        ::.||.||:...:..|.
Human   649 GRLFAP-------PSPETGEAKR-----SAFVE--------VKKAARAASLQEEGTAD------- 686

  Fly   684 TEMAYSYKKSQRYGNAVSPDSSSNLGQNPEQLSSSAVVVGEQEMTRATMIKGECSPPP----PSH 744
                         |..|:.:.....|.......::|..||.:::         .:|.|    ||.
Human   687 -------------GAGVASEDQDAGGGGGSSTPAAASPVGAEKL---------LAPRPGGPLPSR 729

  Fly   745 HHHNVIFSPSRHAAY-----LG-AGE-AGGHSPSPGYPGYPHYGAAATSTFHSPPHSSHSPFDRQ 802
            ....   ||:|.:|:     || ||. :||.....|..|....|..|.|.            :|:
Human   730 LEGG---SPARGSAFTSVPQLGSAGSTSGGGGTGAGAAGGAGGGQGAASD------------ERK 779

  Fly   803 SNASSGAGSATNLHLLQTSTQMLNHPL--MQPLTPLQRLSPLRISPPS----------------- 848
            |..|..|.|.:     |.|..:|...|  ::|..|...:.|.|:.|.:
Human   780 SAFSQPARSFS-----QLSPLVLGQKLGALEPCHPADGVGPTRLYPAAADPLAVKLQGAADLNGG 839

  Fly   849 --SLSPDGNSCPR-------------------------SGSPL-----SPNSLASRGYRSLPYPL 881
              ||...|...|:                         :..||     |..:|....:.||..|.
Human   840 CGSLPSGGGGLPKQSPFLYATAFWPKSSAAAAAAAAAAAAGPLQLQLPSALTLLPPSFTSLCLPA 904

  Fly   882 KKKDGKMHYECNVCCKTFGQLSNLKVHLRTH-------------SGERPFKCNVCTKSFTQLAHL 933
            :.       .|..|..:|...|:|..|:|:|             ..|...||.:|.:||.:..||
Human   905 QN-------WCAKCNASFRMTSDLVYHMRSHHKKEYAMEPLVKRRREEKLKCPICNESFRERHHL 962

  Fly   934 QKHHLVH 940
            .:|...|
Human   963 SRHMTSH 969

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	36/142 (25%)
		C2H2 Zn finger	892..912	CDD:275368	7/19 (37%)
		zf-H2C2_2	904..929	CDD:290200	10/37 (27%)
		C2H2 Zn finger	920..940	CDD:275368	7/19 (37%)
		zf-H2C2_2	932..957	CDD:290200	4/9 (44%)
		C2H2 Zn finger	948..968	CDD:275368
		zf-H2C2_2	960..985	CDD:290200
		C2H2 Zn finger	976..996	CDD:275368
		C2H2 Zn finger	1004..1023	CDD:275368
PRDM8	XP_011530435.1	SET	309..411	CDD:279228	34/137 (25%)
		C2H2 Zn finger	908..928	CDD:275368	7/19 (37%)
		zf-C2H2	948..969	CDD:278523	8/20 (40%)
		C2H2 Zn finger	949..969	CDD:275368	7/19 (37%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810