DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and prdm8b

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	NP_001098575.1	Gene:	prdm8b / 557162	ZFINID:	ZDB-GENE-060526-174	Length:	570	Species:	Danio rerio

Alignment Length:	881	Identity:	157/881 - (17%)
Similarity:	255/881 - (28%)	Gaps:	390/881 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 KTLPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPN---------DKNKAR 175
            |.:.:.||...:.||:|.:           ||....|||.....||.|.:         ||..|.
Zfish    19 KAMQQCLTDIFTSVYTTCD-----------IPENAIFGPCVLSHTSLYDSIAFIALKSTDKRTAP 72

  Fly   176 YFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQSN-------WMRYVASAYSLSVMNLVACQHQ 233
            |.:||                         |.|.:|       |:|.|.||......||.|....
Zfish    73 YIFRV-------------------------DTSAANNSSEGLMWLRLVQSARDRDEQNLEAYVKN 112

  Fly   234 ENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPETTIFGACKQAVEAEEEADEEEEEAEGEDG 298
            ..:::.:.|.|..:|||:|||.||..         |..:..:.:..|:::.
Zfish   113 GQLFYRSLRRIEKDEELLVWYGKDLI---------ELLLLSSSRNQVKSKG-------------- 154

  Fly   299 KPRYSMPAPEIPPDVA---------VSHITY-----VMGLHLPVGAGNGPANGSVAGSVSGATPP 349
                  .:|.:.||.:         ::|:.:     :.|:       :.|...:...|...:.||
Zfish   155 ------TSPFLCPDCSQRFQFEFPFLAHLRFRCTKRLQGM-------SSPEEEAKDASDQASLPP 206

  Fly   350 PPTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIGQDRSP------MASSDKDTAGSP 408
                    .||||                  :.||.......||..|      :|...::...||
Zfish   207 --------ARSSP------------------KLGRSDGFSNPQDGKPSTDFHNLARDLENNRTSP 245

  Fly   409 LSGLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPP----EDSSDSESEHN--YVLDCSKKAIA 467
            .|..:.::..:....|.....|     :....||:.|    |:.::|..::.  |.||.|::|.:
Zfish   246 PSDKEAEILSESSGKRKFSDME-----DSRNSGLSQPTKSKEELANSAQQYRGVYGLDESRRAFS 305

  Fly   468 PKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTATPICETDKNEYRKFKVKMPLKYEFKNKT 532
            |.                  ::.||                ||.::.:.:.|
Zfish   306 PS------------------VSETT----------------ETKRSAFTEVK------------- 323

  Fly   533 CVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHLGDEHMLMMERERERERERIQERE 597
              |....||...:..|...|.:|....:..|           .::|:.:        |:.:.|.:
Zfish   324 --KSSQGLKHSGKNSSFNSENKEAGRPNSNP-----------AEKHLNI--------RQVLSETQ 367

  Fly   598 PSNQQPASSTV-----IVLEHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSSSILETILTSQ 657
            |...:..:|::     .|.:|:.||                  .||...|.|||.:..:
Zfish   368 PPQSRMETSSIGSAFTSVPQHSGGG------------------SERKSAFSQPSRTFSQ------ 408

  Fly   658 HRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQNPEQLSSSAVVV 722
                                   .||..||                        |:.|.:.
Zfish   409 -----------------------LSPLVMA------------------------PKLLPAV---- 422

  Fly   723 GEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEAGGHSPSPGYPGYPHYGAAATST 787
                         :|.|........:.::.....||.|...|.|.:.|.|.       |.|
Zfish   423 -------------DCHPTVGDTVSSSRLYQADHLAAKLQGSELGSNCPVPS-------GIA---- 463

  Fly   788 FHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQMLNHPLMQPLTPLQRLSPLRISPPSSLSP 852
                   ..|||                  |.|:.       ..|.|.    .|:::..||:|:
Zfish   464 -------KQSPF------------------LYTTA-------FWPKTS----GPIQLQMPSALT- 491

  Fly   853 DGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQLSNLKVHLRTH----- 912
                       |.|.|     :.||..|.:.       .|..|..:|...|:|..|:|:|
Zfish   492 -----------LLPPS-----FTSLCLPAQN-------WCAKCNASFRMTSDLVYHMRSHHKKEF 533

  Fly   913 --------SGERPFKCNVCTKSFTQLAHLQKHHLVH 940
                    ..|...||.:|.:||.:..||.:|...|
Zfish   534 AMEPLVKRRREEKLKCPICNESFRERHHLSRHMTSH 569

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	38/142 (27%)
		C2H2 Zn finger	892..912	CDD:275368	7/19 (37%)
		zf-H2C2_2	904..929	CDD:290200	10/37 (27%)
		C2H2 Zn finger	920..940	CDD:275368	7/19 (37%)
		zf-H2C2_2	932..957	CDD:290200	4/9 (44%)
		C2H2 Zn finger	948..968	CDD:275368
		zf-H2C2_2	960..985	CDD:290200
		C2H2 Zn finger	976..996	CDD:275368
		C2H2 Zn finger	1004..1023	CDD:275368
prdm8b	NP_001098575.1	SET	32..134	CDD:279228	35/137 (26%)
		C2H2 Zn finger	508..528	CDD:275368	7/19 (37%)
		zf-C2H2	548..569	CDD:278523	8/20 (40%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810