DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and prdm1

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	XP_002937203.1	Gene:	prdm1 / 493207	XenbaseID:	XB-GENE-853254	Length:	784	Species:	Xenopus tropicalis

Alignment Length:	1034	Identity:	306/1034 - (29%)
Similarity:	399/1034 - (38%)	Gaps:	387/1034 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    88 DVTRMREEDFERLAVYLVPDVQAERGLPN----RADKTLPRSLTLKSSMVYSTPNVKTEGVWSSG 148
            |:|...|.:||....|:|.|..::.....    :|..:|||:|..|    |::...:..||.|..
Frog     9 DMTLWSETEFEEKCTYIVKDHSSDSSSEGSNVAQAQASLPRNLLFK----YASGCKEVIGVVSKE 69

  Fly   149 VIPRGTRFGPFEGIPTSNYPND---KNKAR-YFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQ 209
            .||:||||||..|   ..|.||   ||..| ||||:       |.|     .:..:::||.:..:
Frog    70 YIPKGTRFGPLVG---EIYTNDTVPKNANRKYFWRI-------YSN-----GEFQHFIDGYNEDK 119

  Fly   210 SNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPETTIFG 274
            |||||||..|:||...||.|||:..||||||.:.|..|:||:||||:|||.||.|....|..:
Frog   120 SNWMRYVNPAHSLQEQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFADRLHYPTSGELVV-- 182

  Fly   275 ACKQAVEAEEEADEEEEEAEGEDGKPRYSMPAPEIPPDVAVSHITYVMGLHLPVGAGNGPANGSV 339
            ..:|::...|   |:.:|...:...|:......||..| ..||:.:               ..::
Frog   183 NLQQSLTIRE---EKRKELTQQKNTPKKEHSVKEILRD-TTSHLKH---------------KDNL 228

  Fly   340 AGSVSGATP------------PPPTATPCCRRSSP-PAHVSTTTSTCNAHHPHIQHGRHASVIIG 391
            ..|:|..||            |..|..|  |...| |:|:         |..:::    |||...
Frog   229 LSSMSAITPEKEKVDVHKNCSPERTFFP--RVVYPFPSHI---------HEDYLK----ASVGYN 278

  Fly   392 QDR------SPMASSDKDTAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSD 450
            .||      ||:..|                                          |.|..||.
Frog   279 MDRQNYLMHSPIQPS------------------------------------------TTPSPSSR 301

  Fly   451 SESEHNYVLDCSKKAIAPKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTATPICETDKNEY 515
            |..:.::                     .||||               ||||.:.........::
Frog   302 SSPDQSF---------------------KSSSP---------------HSSPGSAVSPHHPLQDH 330

  Fly   516 RKFKVKMPLKYEFKNKTCVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHLGDEHML 580
            ::|       |.|.|:                                    |..|..||
Frog   331 KEF-------YPFINR------------------------------------PYNTEGLG----- 347

  Fly   581 MMERERERERERIQEREPSNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQP 645
                                                         |.|.|.|            |
Frog   348 ---------------------------------------------SFPTYAP------------P 355

  Fly   646 SSSILETILTSQHRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYG---NAVSPDSSSN 707
            :|.:                            ||..|.....||......||   |.::..::.|
Frog   356 TSHL----------------------------PPFVSSYNSTYSKYLLPPYGIGCNGLNSLNNIN 392

  Fly   708 LGQNPEQLSSSAVVVGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGA--GEAGGHSP 770
            ...|....|....|.       ::|:.|...|      ||.:     .|||..|:  .|.|....
Frog   393 AINNFNPFSRMYPVY-------SSMLAGGSLP------HHLL-----THAALPGSLPHEGGRRLL 439

  Fly   771 SPGYP----------GYPHYGAAATSTFHSPPHSSHSPFDRQSNASSG---AGSATNLHLLQTST 822
            .|..|          .:...||||            |..|:||:.:||   ||:|.:
Frog   440 QPELPRDFLIPAPNSAFSITGAAA------------SMKDKQSSPTSGSPTAGTAAS-------- 484

  Fly   823 QMLNHPLMQPLTPLQRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASR----GYRSLPYPLKK 883
              |.| :|||            .|.|::.       .:.|..:.|.:.|:    ||::|||||||
Frog   485 --LEH-IMQP------------KPTSAVM-------STSSEEAINLIKSKRNMTGYKTLPYPLKK 527

  Fly   884 KDGKMHYECNVCCKTFGQLSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQC 948
            ::||:.||||||.||||||||||||||.|||||||||..|.|.||||||||||.|||||||||:|
Frog   528 QNGKIKYECNVCSKTFGQLSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHFLVHTGEKPHEC 592

  Fly   949 DICKKRFSSTSNLKTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYIS 1013
            .:|.||||||||||||||||||:|||.|.|||.||||||||||||||||.:||:.|..|.|.||.
Frog   593 QVCHKRFSSTSNLKTHLRLHSGEKPYQCKLCPAKFTQFVHLKLHKRLHTRERPHKCIHCHKSYIH 657

  Fly  1014 ASGLRTHWKTTSC--KP---------NNLEEELAMAAAATSECLDKDHPEPDSREAYEQ 1061
            ...|..|.| .:|  .|         |.:.||:.....:.|.....|..:.|...|.|:
Frog   658 LCSLNFHMK-GNCPVSPRLGVSREDLNRMNEEIEKFDISDSADRLDDMEDMDMSPAVEK 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	58/130 (45%)
		C2H2 Zn finger	892..912	CDD:275368	18/19 (95%)
		zf-H2C2_2	904..929	CDD:290200	19/24 (79%)
		C2H2 Zn finger	920..940	CDD:275368	14/19 (74%)
		zf-H2C2_2	932..957	CDD:290200	19/24 (79%)
		C2H2 Zn finger	948..968	CDD:275368	16/19 (84%)
		zf-H2C2_2	960..985	CDD:290200	20/24 (83%)
		C2H2 Zn finger	976..996	CDD:275368	17/19 (89%)
		C2H2 Zn finger	1004..1023	CDD:275368	7/18 (39%)
prdm1	XP_002937203.1	PR-SET_PRDM1	45..172	CDD:380964	64/145 (44%)
		COG5048	<446..647	CDD:227381	129/242 (53%)
		C2H2 Zn finger	536..556	CDD:275368	18/19 (95%)
		C2H2 Zn finger	564..584	CDD:275368	14/19 (74%)
		zf-H2C2_2	576..601	CDD:372612	19/24 (79%)
		C2H2 Zn finger	592..612	CDD:275368	16/19 (84%)
		C2H2 Zn finger	620..640	CDD:275368	17/19 (89%)
		C2H2 Zn finger	648..666	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11562
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I1983
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233655at33208
OrthoFinder	1	1.000	-	-		FOG0006205
OrthoInspector	1	1.000	-	-		oto102944
Panther	1	1.100	-	-	LDO	PTHR16515
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4128
SonicParanoid	1	1.000	-	-		X5144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100