DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and Prdm4

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	XP_006241222.1	Gene:	Prdm4 / 170820	RGDID:	619929	Length:	805	Species:	Rattus norvegicus

Alignment Length:	941	Identity:	193/941 - (20%)
Similarity:	300/941 - (31%)	Gaps:	373/941 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 GEDGKPRYS-MPAPEIP---PDV--AVSHITYVMGLHLPVGAGNGPANGSVAG--SVSGATPPPP 351
            |....|.:| :|||.:|   |::  ::|.:...:.|.||:|.|:   .|.:.|  ..:...||||
  Rat    31 GLAASPSHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGD---RGVMCGLPERNYTLPPPP 92

  Fly   352 TATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIG-----QDRSP-------MASSDKDT 404
                                     :||::.....:::.|     .||.|       ..:.|.:|
  Rat    93 -------------------------YPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNT 132

  Fly   405 A----GSPLSGLDHQMTPQDGSV-----------RSVRSD--EGYHSNECHEDGL---------- 442
            |    .:| |.||....  :|:|           |||.:.  :..|.|:.||..|
  Rat   133 ALSITNNP-SALDPYQA--NGNVGLELGIVSIDSRSVNTHGAQSLHPNDGHEVALDTTITMENVS 194

  Fly   443 --TPPEDSSDSESEHNYVLDCSKKAIAPKETVIAQAQKPSSSPPAV-VMANTTTNSMISHSSPTA 504
              |.| .|:|..:|     :.:...:..:.:.|....: |..|.:| .::|..|...:.|..  .
  Rat   195 RVTSP-ISTDGMAE-----ELTMDGVTGEHSQIPNGSR-SHEPLSVDSVSNNLTADTVGHGG--V 250

  Fly   505 TPI----------CETDKNEYR---------------------KFKVKMPLKYEFKNKTCVKQEP 538
            .||          .|||....|                     ...|.:...:...:...|
  Rat   251 IPIHGNGLELPVVMETDHIANRVNGISDSVLSDSIHTVAMSTNSVSVALSTSHNLASLESV---- 311

  Fly   539 SLKEVDQEMSLPQEEEEDQVMHPEPDSICPST-TTHLGDEHMLMMERERERERERIQEREPSNQQ 602
            ||:||.  :||            ||.::...| ...:|..|:.:...........:|..:.::.:
  Rat   312 SLQEVG--LSL------------EPVAVSSITQEVAMGTGHVDVSSDSLSFVPSSLQMEDSNSNK 362

  Fly   603 PASSTVIVL--------------EHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSSSIL--- 650
            ...:|:..:              :|.         |::   :.||.|.|...|...|...:|
  Rat   363 ENMATLFTIWCTLCDRAYPSDCPDHG---------PVT---FVPDTPIESRARLSLPKQLVLRQS 415

  Fly   651 ------------------ETI--------LTSQ--HRLEAA------------------------ 663
                              |||        |..|  |.:|.|
  Rat   416 IVGTDVVGVLPLIGVWTAETIPVRTCFGPLIGQQSHSMEVAEWTDKAVSHVWKIYHNGVLEFCII 480

  Fly   664 -------------AAAANACRQANAATP-------------PPTSPTEMAYSYKKSQRYGNAVSP 702
                         ..|.|...|...|.|             ||.:.....||...:|:.|....|
  Rat   481 TTDENECNWMMFVRKARNREEQNLVAYPHDGKIYFCTSQDIPPENELLFYYSRDYAQQIGVPEHP 545

  Fly   703 D-SSSNLGQNPEQLSSSAVVVGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEAG 766
            | ...|.|:                         |||             |.|...|:| .....
  Rat   546 DVHLCNCGK-------------------------ECS-------------SYSEFKAHL-TSHIH 571

  Fly   767 GHSPSPGYPGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQMLNHPLMQ 831
            .|.||.|:           |:.|.|.||....: :.|.......|.:.||:     ..:.|..|:
  Rat   572 NHLPSQGH-----------SSSHGPSHSKERKW-KCSMCPQAFISPSKLHV-----HFMGHMGMK 619

  Fly   832 PLTPLQRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCC 896
            |                                                         ::|:.|.
  Rat   620 P---------------------------------------------------------HKCDFCS 627

  Fly   897 KTFGQLSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNL 961
            |.|...|||:.||:.|:|::.::|.:|.|||||.|||:.|.::|||||..:||.|.|.|....:|
  Rat   628 KAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQDL 692

  Fly   962 KTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLRTHWKTTSC 1026
            |.|:.:|:.::...|..|.:.|.:..|||.|...|...|.|||:.|.|.|::...|..|.|  :|
  Rat   693 KQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGRRDYVCEKCTKAYLTKYHLTRHLK--AC 755

  Fly  1027 KPNNLEEELAMAAAATSECLDKDHPEPDSRE 1057
            |          ..|::|...|.:..:.||.|
  Rat   756 K----------EPASSSSAQDDEDEDGDSGE 776

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614
		C2H2 Zn finger	892..912	CDD:275368	9/19 (47%)
		zf-H2C2_2	904..929	CDD:290200	11/24 (46%)
		C2H2 Zn finger	920..940	CDD:275368	11/19 (58%)
		zf-H2C2_2	932..957	CDD:290200	13/24 (54%)
		C2H2 Zn finger	948..968	CDD:275368	8/19 (42%)
		zf-H2C2_2	960..985	CDD:290200	7/24 (29%)
		C2H2 Zn finger	976..996	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1004..1023	CDD:275368	6/18 (33%)
Prdm4	XP_006241222.1	zf_PR_Knuckle	361..398	CDD:375871	5/48 (10%)
		PR-SET_PRDM4	401..540	CDD:380966	21/138 (15%)
		C2H2 Zn finger	550..569	CDD:275368	9/57 (16%)
		C2H2 Zn finger	595..615	CDD:275368	4/24 (17%)
		C2H2 Zn finger	623..643	CDD:275368	9/19 (47%)
		zf-H2C2_2	635..660	CDD:404364	11/24 (46%)
		C2H2 Zn finger	651..671	CDD:275368	11/19 (58%)
		zf-H2C2_2	663..686	CDD:404364	12/22 (55%)
		C2H2 Zn finger	679..699	CDD:275368	8/19 (42%)
		zf-H2C2_2	691..716	CDD:404364	7/24 (29%)
		C2H2 Zn finger	707..727	CDD:275368	7/19 (37%)
		C2H2 Zn finger	735..753	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810