DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and Prdm1

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	XP_006512568.1	Gene:	Prdm1 / 12142	MGIID:	99655	Length:	856	Species:	Mus musculus

Alignment Length:	966	Identity:	290/966 - (30%)
Similarity:	379/966 - (39%)	Gaps:	328/966 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 QDYDVTRMREEDFERLAVYLVP----DVQAERGLPNRADKTLPRSLTLKSSMVYSTPNVK-TEGV 144
            :|.|:|...|.:||....|:|.    |..|:.|...:|:.:|||:|..|    |:..|.| ..||
Mouse    73 EDADMTLWTEAEFEEKCTYIVNDHPWDSGADGGTSVQAEASLPRNLLFK----YAANNSKEVIGV 133

  Fly   145 WSSGVIPRGTRFGPFEGIPTSNYPND---KNKAR-YFWRVQGTRHITYGNIKIFKDDDYYYLDGS 205
            .|...||:||||||..|   ..|.||   ||..| ||||:..            :::.::::||.
Mouse   134 VSKEYIPKGTRFGPLIG---EVYTNDTVPKNANRKYFWRIYS------------REEFHHFIDGF 183

  Fly   206 DRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNEELMVWYCKDFASRLGYDVDPET 270
            :..:|||||||..|:|....||.|||:..||||||.:.|..|:||:||||:|||.||.|....|.
Mouse   184 NEEKSNWMRYVNPAHSAREQNLAACQNGMNIYFYTIKPIPANQELLVWYCRDFAERLHYPYPGEL 248

  Fly   271 TIFGACKQAVEAEEEADEEEEEAEGEDGKPRYSMPAPEIPPDVAVSHITYVMGLHLPVGAGNGPA 335
            |:...                 .:.|....:||....|:.|
Mouse   249 TVINL-----------------TQTESNPKQYSSEKNELYP------------------------ 272

  Fly   336 NGSVAGSVSGATPPPPTATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIGQDRSPMASS 400
                                   :|.|....|                  ...|:..|.:|  |.
Mouse   273 -----------------------KSVPKREYS------------------VKEILKLDSNP--SK 294

  Fly   401 DKDTAGSPLS--GLDHQMTPQDGSVRSVRSDEGYHSNECHEDGLTPPEDSSDSESEHNYVLDCSK 463
            .||...|.:|  .|:..|   ||..::...|..::....:......|||          .|..|.
Mouse   295 RKDIYRSNISPFTLEKDM---DGFRKNGSPDMPFYPRVVYPIRAPLPED----------FLKASL 346

  Fly   464 KAIAPKETVIAQAQKPSS---SPPAVVMANTTTNSMISHSSP--TATPICETDKNEYRKFKVKMP 523
            .....:.|.|..:..|||   ||||......:..|...||||  |.:|:..
Mouse   347 AYGMERPTYITHSPLPSSTTPSPPASSSPEQSLKSSSPHSSPGNTVSPLAP-------------- 397

  Fly   524 LKYEFKNKTCVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHLGDEHMLMMERERER 588
                                    .||:..:
Mouse   398 ------------------------GLPEHRD---------------------------------- 404

  Fly   589 ERERIQEREPSNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPP---------GERYMRFGQ 644
                            |.:.:.:.:.|.|..      |.|.|.|.|.         ...|.:|..
Mouse   405 ----------------SYSYLNVSYGSEGLG------SYPGYAPAPHLPPAFIPSYNAHYPKFLL 447

  Fly   645 PSSSILETILTSQHRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLG 709
            |...|....|::.:.:...         .|.:..|...|.           |.|.:|..|..:..
Mouse   448 PPYGISSNGLSTMNNINGI---------NNFSLFPRLYPV-----------YSNLLSGSSLPHPM 492

  Fly   710 QNPEQLSSSAVVVGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEAGGHSPSPGY 774
            .||..|.||....|.:.:.            ||.|....:|  |:.|:|:...|
Mouse   493 LNPASLPSSLPTDGARRLL------------PPEHPKEVLI--PAPHSAFSLTG----------- 532

  Fly   775 PGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQ---TSTQMLNHPLMQPLTPL 836
                  .||:.....|||          |.:.:...:||:.|::|   ||:.|
Mouse   533 ------AAASMKDESSPP----------SGSPTAGTAATSEHVVQPKATSSVM------------ 569

  Fly   837 QRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVCCKTFGQ 901
                    :.||:   ||      ...|..|.....||::|||||||::||:.||||||.|||||
Mouse   570 --------AAPST---DG------AMNLIKNKRNMTGYKTLPYPLKKQNGKIKYECNVCAKTFGQ 617

  Fly   902 LSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLR 966
            |||||||||.|||||||||..|.|.||||||||||:|||||||||:|.:|.||||||||||||||
Mouse   618 LSNLKVHLRVHSGERPFKCQTCNKGFTQLAHLQKHYLVHTGEKPHECQVCHKRFSSTSNLKTHLR 682

  Fly   967 LHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLRTHWK 1022
            ||||:|||.|.:||.||||||||||||||||.:||:.|..|.|.||....|:.|.|
Mouse   683 LHSGEKPYQCKVCPAKFTQFVHLKLHKRLHTRERPHKCAQCHKSYIHLCSLKVHLK 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	57/131 (44%)
		C2H2 Zn finger	892..912	CDD:275368	18/19 (95%)
		zf-H2C2_2	904..929	CDD:290200	19/24 (79%)
		C2H2 Zn finger	920..940	CDD:275368	14/19 (74%)
		zf-H2C2_2	932..957	CDD:290200	19/24 (79%)
		C2H2 Zn finger	948..968	CDD:275368	16/19 (84%)
		zf-H2C2_2	960..985	CDD:290200	19/24 (79%)
		C2H2 Zn finger	976..996	CDD:275368	16/19 (84%)
		C2H2 Zn finger	1004..1023	CDD:275368	8/19 (42%)
Prdm1	XP_006512568.1	PR-SET_PRDM1	112..240	CDD:380964	63/146 (43%)
		COG5048	452..719	CDD:227381	147/356 (41%)
		C2H2 Zn finger	608..628	CDD:275368	18/19 (95%)
		C2H2 Zn finger	636..656	CDD:275368	14/19 (74%)
		C2H2 Zn finger	664..684	CDD:275368	16/19 (84%)
		C2H2 Zn finger	692..712	CDD:275368	16/19 (84%)
		C2H2 Zn finger	720..738	CDD:275368	7/17 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837199
Domainoid	1	1.000	50	1.000	Domainoid score	I11688
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1966
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006205
OrthoInspector	1	1.000	-	-		oto92654
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR16515
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4128
SonicParanoid	1	1.000	-	-		X5144
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.970