DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and PRDM4

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	XP_005268650.1	Gene:	PRDM4 / 11108	HGNCID:	9348	Length:	808	Species:	Homo sapiens

Alignment Length:	942	Identity:	190/942 - (20%)
Similarity:	300/942 - (31%)	Gaps:	376/942 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 GEDGKPRYS-MPAPEIP---PDV--AVSHITYVMGLHLPVGAGNGPANGSVAG--SVSGATPPPP 351
            |....|.:| :|||.:|   |::  ::|.:...:.|.||:|.|:   .|.:.|  ..:...||||
Human    35 GLAASPTHSAIPAPGLPVAIPNLGPSLSSLPSALSLMLPMGIGD---RGVMCGLPERNYTLPPPP 96

  Fly   352 TATPCCRRSSPPAHVSTTTSTCNAHHPHIQHGRHASVIIG-----QDRSP-------MASSDKDT 404
                                     :||::.....:::.|     .||.|       ..:.|.:|
Human    97 -------------------------YPHLESSYFRTILPGILSYLADRPPPQYIHPNSINVDGNT 136

  Fly   405 A----GSPLSGLDHQMTPQDGSV-----------RSVRSD--EGYHSNECHEDGL---------- 442
            |    .:| |.||...:  :|:|           |||.:.  :..|.::.||..|
Human   137 ALSITNNP-SALDPYQS--NGNVGLEPGIVSIDSRSVNTHGAQSLHPSDGHEVALDTAITMENVS 198

  Fly   443 --TPPEDSSDSESEHNYVLDCSKKAIAPKETVIAQAQKPSSSPPAVVMANTTTNSMIS------- 498
              |.| .|:|..:|     :.:...:|.:.:.|....: |..|.:|   ::.:|::.:
Human   199 RVTSP-ISTDGMAE-----ELTMDGVAGEHSQIPNGSR-SHEPLSV---DSVSNNLAADAVGHGG 253

  Fly   499 ----HSSPTATP-ICETDKNEYR---------------------KFKVKMPLKYEFKNKTCVKQE 537
                |.:....| :.|||....|                     ...|.:...:...:...|
Human   254 VIPMHGNGLELPVVMETDHIASRVNGMSDSALSDSIHTVAMSTNSVSVALSTSHNLASLESV--- 315

  Fly   538 PSLKEVDQEMSLPQEEEEDQVMHPEPDSICPST-TTHLGDEHMLMMERERERERERIQEREPSNQ 601
             ||.||.  :||            ||.::...| ...:|..|:.:...........:|..:.::.
Human   316 -SLHEVG--LSL------------EPVAVSSITQEVAMGTGHVDVSSDSLSFVSPSLQMEDSNSN 365

  Fly   602 QPASSTVIVL--------------EHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSSSIL-- 650
            :...:|:..:              ||.         |::   :.||.|.|...|...|...:|
Human   366 KENMATLFTIWCTLCDRAYPSDCPEHG---------PVT---FVPDTPIESRARLSLPKQLVLRQ 418

  Fly   651 -------------------ETI--------LTSQ--HRLEAA----------------------- 663
                               |||        |..|  |.:|.|
Human   419 SIVGAEVVGVLPLTGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCI 483

  Fly   664 --------------AAAANACRQANAATP-------------PPTSPTEMAYSYKKSQRYGNAVS 701
                          ..|.|...|...|.|             ||.:.....||...:|:.|....
Human   484 ITTDENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIGVPEH 548

  Fly   702 PD-SSSNLGQNPEQLSSSAVVVGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEA 765
            || ...|.|               :|....|..|...     :.|.||
Human   549 PDVHLCNCG---------------KECNSYTEFKAHL-----TSHIHN----------------- 576

  Fly   766 GGHSPSPGYPGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQMLNHPLM 830
              |.|:.|:.|           .|.|.||....: :.|.......|.:.||:     ..:.|..|
Human   577 --HLPTQGHSG-----------SHGPSHSKERKW-KCSMCPQAFISPSKLHV-----HFMGHMGM 622

  Fly   831 QPLTPLQRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVC 895
            :|                                                         ::|:.|
Human   623 KP---------------------------------------------------------HKCDFC 630

  Fly   896 CKTFGQLSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSN 960
            .|.|...|||:.||:.|:|::.::|.:|.|||||.|||:.|.::|||||..:||.|.|.|....:
Human   631 SKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAHLESHMVIHTGEKNLKCDYCDKLFMRRQD 695

  Fly   961 LKTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTNDRPYVCQGCDKKYISASGLRTHWKTTS 1025
            ||.|:.:|:.::...|..|.:.|.:..|||.|...|...|.|||:.|.|.|::...|..|.||
Human   696 LKQHVLIHTQERQIKCPKCDKLFLRTNHLKKHLNSHEGKRDYVCEKCTKAYLTKYHLTRHLKT-- 758

  Fly  1026 CKPNNLEEELAMAAAATSECLDKDHPEPDSRE 1057
            ||           ...:|....::..|.||.|
Human   759 CK-----------GPTSSSSAPEEEEEDDSEE 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614
		C2H2 Zn finger	892..912	CDD:275368	9/19 (47%)
		zf-H2C2_2	904..929	CDD:290200	11/24 (46%)
		C2H2 Zn finger	920..940	CDD:275368	11/19 (58%)
		zf-H2C2_2	932..957	CDD:290200	13/24 (54%)
		C2H2 Zn finger	948..968	CDD:275368	8/19 (42%)
		zf-H2C2_2	960..985	CDD:290200	7/24 (29%)
		C2H2 Zn finger	976..996	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1004..1023	CDD:275368	6/18 (33%)
PRDM4	XP_005268650.1	SET	433..540	CDD:321994	17/106 (16%)
		C2H2 Zn finger	554..591	CDD:275368	14/86 (16%)
		C2H2 Zn finger	599..619	CDD:275368	4/24 (17%)
		zf-C2H2	625..647	CDD:306579	9/21 (43%)
		C2H2 Zn finger	627..647	CDD:275368	9/19 (47%)
		zf-H2C2_2	639..664	CDD:316026	11/24 (46%)
		C2H2 Zn finger	655..675	CDD:275368	11/19 (58%)
		zf-H2C2_2	667..690	CDD:316026	12/22 (55%)
		C2H2 Zn finger	683..703	CDD:275368	8/19 (42%)
		C2H2 Zn finger	711..731	CDD:275368	7/19 (37%)
		C2H2 Zn finger	739..758	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810