DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and PRDM5

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	NP_001366033.1	Gene:	PRDM5 / 11107	HGNCID:	9349	Length:	641	Species:	Homo sapiens

Alignment Length:	943	Identity:	188/943 - (19%)
Similarity:	284/943 - (30%)	Gaps:	389/943 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 LPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPNDKNK---ARYFWRVQGT 183
            :|...:||||.|..     ..|::::..:.:|.:||||.|  ....|.|.::   .|..|.|:|:
Human     6 VPDRFSLKSSRVQD-----GMGLYTARRVRKGEKFGPFAG--EKRMPEDLDENMDYRLMWEVRGS 63

  Fly   184 RHITYGNIKIFKDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDILPNE 248
                       |.:..|.||.::...|||:|:|..|.|....||.|.|..|||::....||..:.
Human    64 -----------KGEVLYILDATNPRHSNWLRFVHEAPSQEQKNLAAIQEGENIFYLAVEDIETDT 117

  Fly   249 ELMVWYCKDFASRLGYDVDPETTIFGACKQAVEAEEEADEEEEE-----AEGEDGKPR------- 301
            ||::.|                         ::::.||:|||::     .|||....|
Human   118 ELLIGY-------------------------LDSDMEAEEEEQQIMTVIKEGEVENSRRQSTAGR 157

  Fly   302 ---------YSMPAPE---IPPDVAVSHITYVMGLHLPVGAGNGPANGSVAGSVSGATPPPPTAT 354
                     |:.|..|   ...|:...|:   ..||
Human   158 KDRLGCKEDYACPQCESSFTSEDILAEHL---QTLH----------------------------- 190

  Fly   355 PCCRRSSPPAHVSTTTSTCNAHHP-------HIQHGRHASVIIGQDRSPMASSDKDTAGSPLSGL 412
                 ..|..........|....|       |:......|.:....||...|....:..|..|..
Human   191 -----QKPTEEKEFKCKNCGKKFPVKQALQRHVLQCTAKSSLKESSRSFQCSVCNSSFSSASSFE 250

  Fly   413 DHQMTPQDGSVRSV-----------------RSDEGYHSNE---------CHEDGLTPPEDSSDS 451
            .||.|.: |..|.|                 |..|..|:.:         |::..     .|:.|
Human   251 QHQETCR-GDARFVCKADSCGKRLKSKDALKRHQENVHTGDPKKKLICSVCNKKC-----SSASS 309

  Fly   452 ESEHNYV------LDCSKKAIAPKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTATPICET 510
            ..||..:      .:|.||.|:                     ||.....||:||....:|:.
Human   310 LQEHRKIHEIFDCQECMKKFIS---------------------ANQLKRHMITHSDMRLSPLI-- 351

  Fly   511 DKNEYRKFKV-KMPLKYEFKNKTCVKQEPSLKEVDQEMSLPQEEEEDQVMHPEPDSICPSTTTHL 574
                   |.: |.|...|..||       |.|.:||..:......||:   |....:|..
Human   352 -------FLIEKRPYNCEICNK-------SFKRLDQVGAHKVIHSEDK---PYKCKLCGK----- 394

  Fly   575 GDEHMLMMERERERERE----RIQEREPSNQQPASSTVIVLEHNSGGQARTIVPLSKPYYEPDPP 635
            |..|..:.:..::...|    :.:|.:...:.|.|....:|.|||
Human   395 GFAHRNVYKNHKKTHSEERPFQCEECKALFRTPFSLQRHLLIHNS-------------------- 439

  Fly   636 GERYMRFGQPSSSILETILTSQHRLEAAAAAANACRQANAATPPPTSPTEMAYSYKKSQRYGNAV 700
             ||..:                            |...:|             ::|:.
Human   440 -ERTFK----------------------------CHHCDA-------------TFKRK------- 455

  Fly   701 SPDSSSNLGQNPEQLSSSAVVVGEQEMTRATMIKGECSPPPPSHHHHNVIFSPSRHAAYLGAGEA 765
                        :.|:....||.|                              ||..|
Human   456 ------------DTLNVHVQVVHE------------------------------RHKKY------ 472

  Fly   766 GGHSPSPGYPGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQMLNHPLM 830
                                                                   ..::.|...:
Human   473 -------------------------------------------------------RCELCNKAFV 482

  Fly   831 QPLTPLQRLSPLRISPPSSLSPDGNSCPRSGSPLSPNSLASRGYRSLPYPLKKKDGKMHYECNVC 895
            .|       |.||....:........||..|     ...||.|  :|...::...|:..|:|..|
Human   483 TP-------SVLRSHKKTHTGEKEKICPYCG-----QKFASSG--TLRVHIRSHTGERPYQCPYC 533

  Fly   896 CKTFGQLSNLKVHLRTHSGERPFKCNVCTKSFTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSN 960
            .|.|.:...||:|:|||:.|:|:||:.|:|:|:|...|.:|...||||||.|||:|...||....
Human   534 EKGFSKNDGLKMHIRTHTREKPYKCSECSKAFSQKRGLDEHKRTHTGEKPFQCDVCDLAFSLKKM 598

  Fly   961 LKTHLRLHSGQKPYA-CDLCPQKFTQFVHLKLH 992
            |..|...|:..:|.| |..|.:|||:..:||:|
Human   599 LIRHKMTHNPNRPLAECQFCHKKFTRNDYLKVH 631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	37/129 (29%)
		C2H2 Zn finger	892..912	CDD:275368	8/19 (42%)
		zf-H2C2_2	904..929	CDD:290200	13/24 (54%)
		C2H2 Zn finger	920..940	CDD:275368	7/19 (37%)
		zf-H2C2_2	932..957	CDD:290200	13/24 (54%)
		C2H2 Zn finger	948..968	CDD:275368	7/19 (37%)
		zf-H2C2_2	960..985	CDD:290200	9/25 (36%)
		C2H2 Zn finger	976..996	CDD:275368	8/17 (47%)
		C2H2 Zn finger	1004..1023	CDD:275368
PRDM5	NP_001366033.1	PR-SET_PRDM5	2..128	CDD:380967	42/164 (26%)
		COG5048	<145..338	CDD:227381	39/256 (15%)
		C2H2 Zn finger	169..190	CDD:275368	4/23 (17%)
		C2H2 Zn finger	201..221	CDD:275368	3/19 (16%)
		C2H2 Zn finger	236..256	CDD:275368	5/19 (26%)
		COG5048	262..631	CDD:227381	114/604 (19%)
		C2H2 Zn finger	264..287	CDD:275368	2/22 (9%)
		C2H2 Zn finger	297..317	CDD:275368	5/24 (21%)
		C2H2 Zn finger	322..342	CDD:275368	8/40 (20%)
		C2H2 Zn finger	361..381	CDD:275368	7/26 (27%)
		C2H2 Zn finger	389..409	CDD:275368	3/24 (13%)
		C2H2 Zn finger	417..437	CDD:275368	4/19 (21%)
		C2H2 Zn finger	445..462	CDD:275368	4/48 (8%)
		C2H2 Zn finger	474..494	CDD:275368	5/26 (19%)
		C2H2 Zn finger	502..522	CDD:275368	7/26 (27%)
		C2H2 Zn finger	530..550	CDD:275368	8/19 (42%)
		C2H2 Zn finger	558..578	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..606	CDD:275368	7/19 (37%)
		C2H2 Zn finger	615..636	CDD:275368	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810