DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and prdm15

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	XP_012813515.1	Gene:	prdm15 / 100494779	XenbaseID:	XB-GENE-1013930	Length:	1202	Species:	Xenopus tropicalis

Alignment Length:	1365	Identity:	247/1365 - (18%)
Similarity:	426/1365 - (31%)	Gaps:	510/1365 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 NRADKTLPRSLTLKSSMVYSTPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYPNDKNKARYFWRV 180
            :||..:||.:|.:|.:      ....|||::...:.:.|:|||||....|..  || :.|:.
Frog    41 SRARSSLPSNLEIKQA------EDGAEGVFAVTPLVKRTQFGPFESKRVSKL--DK-EPRFL--- 93

  Fly   181 QGTRHITYGNIKIF-KDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENIYFYTTRDI 244
                      :|:| ||......|.|.....|||.:|..|...:..||.|.||..::||.|::||
Frog    94 ----------LKVFHKDGRSELCDTSSEDDCNWMMFVRPAADFTHQNLTAFQHGNDVYFTTSQDI 148

  Fly   245 LPNEELMVWYCKDFASRLGYDVDPETTIFGACKQAVEAEEEADEEEEEAEGEDGKPRYSMPAPEI 309
            ....||.|||...:|.|:      |..:.   |.|:....|.:....|.| :|..|..|...|..
Frog   149 ALGAELRVWYAAFYARRM------EKALL---KPAIPCHSEVNFLAAEPE-KDLNPSSSSKTPPT 203

  Fly   310 ----PPDVAVSHITYVMGLHLPVGAGNGPANGSVAGSVSGATPPPPTATPCCRRSSPPAHVSTTT 370
                |..:.|:|                              ||....:..|:.:|...||.|..
Frog   204 AILSPKKMKVTH------------------------------PPAAYTSVSCQDNSDIIHVETCH 238

  Fly   371 STCNAHHPHIQHGRHASVIIGQDRSPMASSDKDTAGSPLSGLDHQMTPQDGSVRSVRSDEGYHSN 435
            .||.                      :.|:   |...|....:|.::               |..
Frog   239 WTCK----------------------VCST---TFIEPNLLTEHLLS---------------HLE 263

  Fly   436 ECHEDGLTPPEDSSDSESEHNYVLDCSKKAIAPKETVIA-----------------QAQKPSSSP 483
            :.  .|:.||     ::.|::| |:|...:::..:|||.                 :::.|..:.
Frog   264 QA--KGIPPP-----TQCENSY-LECDTVSVSADQTVICADSNQNLEVKKKPKRGRKSKVPKGNI 320

  Fly   484 PAVVMANTTTNSMISHSSPTATPICETDKNEYRKFKVKMPLKYEFKNKTCVKQEPSLKEVDQEMS 548
            |.|::.:   :|...|:.....|:..:|:  ..:...::|                    ..::.
Frog   321 PLVIVDD---DSPAEHNPILYNPVFSSDR--VAEIITEIP--------------------PDDVQ 360

  Fly   549 LPQEEEEDQVMH------PEPDSICPSTT------THLGDEHMLMMERERERERERIQEREPSNQ 601
            || .:.||:.|.      |...:..|..:      |....:..:::...|...|.:...:...::
Frog   361 LP-HDPEDKFMELMLGKLPNAANSLPPVSKFAFHQTSSSVKRSMLLPGSRHAIRRKFARQLGDHK 424

  Fly   602 QPASSTVIV-LEHNSGGQARTIVPLSKPYYEPDPPGERYMRFGQPSSSILETILTSQHRLEAAA- 664
            :.....:.. :..||...:|.:.......::.:...:.:.|    ..|:.:.:.....|.|...
Frog   425 RVFQCNICAKVFRNSSNLSRHVRSHGDKLFKCEECSKLFSR----KESLKQHVSYKHSRNEVDGD 485

  Fly   665 --AAANACRQA----------NAATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQNPEQLSS 717
              ...|.|.:|          |..|...:...||.|.:.           .::|||.::.::
Frog   486 YRYRCNTCEKAFRIQGFLEFHNCRTDDKSFQCEMCYRFF-----------STNSNLSKHKKK--- 536

  Fly   718 SAVVVGEQEMT----------RATMIKGECSPPPPSHH--HHNVIFSPSRHAAYLGAGEAGGHSP 770
                .||::..          |..|::         ||  |...:....|.:.:.....:..:..
Frog   537 ----HGEKKFACEICNKLFYRRDVMLE---------HHRRHLEGVRRVKRESLHQNTDNSIRYKK 588

  Fly   771 SPGYPGYPHYGAAATSTFHSPPHSSHSPFDRQSNASSGAGSATNLHLLQTSTQ------------ 823
            .|.  ..|..|               ..|..:||        .|.|||....:
Frog   589 EPS--ACPVCG---------------KMFSCRSN--------MNKHLLTHGDKKYTCEICGRKFF 628

  Fly   824 ----MLNH--------PLMQPLTPLQRLSPLRISPPSS---------LSPDGNSCPR------SG 861
                :.:|        .||......:.:..:.||...:         ..|...||.|      .|
Frog   629 RVDVLRDHIHIHFKDIALMNDQQREEFIGKIGISSEDNDENSDGSVETEPHKYSCKRCQISFARG 693

  Fly   862 SPLSPNSL---ASRGY-----------------------RSLPYPLKKKDGKMHYECNVCCKTFG 900
            .....:.:   |..||                       .:||.|   :..|..:.|.||.:.|.
Frog   694 KEYLKHIMDIHAENGYDCSICHRRFALKATYHAHMVIHRENLPDP---EVQKYIHPCEVCGRIFN 755

  Fly   901 QLSNLKVHLRTHSGERPFKCNVCTKSFT---------------------------QLAHLQKHHL 938
            .:.||:.|...|||.:...|..|.|||.                           :..|..:||:
Frog   756 SIGNLERHKLIHSGVKSHGCEQCGKSFARKDMLKEHMRVHDNIREYLCAECGKGMKTKHALRHHM 820

  Fly   939 -VHTGEKPHQCDICKKRFSSTSNLKTHLRLHSGQKPYACDLCPQKFTQFVHLKLHKRLHTN-DRP 1001
             :|.|.|.::|..|.:||:...|:..|.:.|:|.|.:.|:||.:.|::...::.||.:||. .:.
Frog   821 KLHKGIKEYECMECHRRFAQKVNMLKHYKRHTGIKDFMCELCGKTFSEKNTMETHKLIHTEVGKQ 885

  Fly  1002 YVCQGCDKKYISASGLRTHWKTT-------SCKPNNLEEELAMAAAATSECLDKDHPE------- 1052
            :.|..|||||::...|:.|.:.|       ||   ||........|:.|..|.:.|||
Frog   886 WTCTVCDKKYVTEYMLQKHVQLTHDKVEAQSC---NLCGTKVSTRASMSRHLRRKHPEVLSVRIE 947

  Fly  1053 --PDSRE------AYEQLTQHMHPAVHPGLRH-------LSSGGQSPPRLIPLGNHMAPQQQSHQ 1102
              .|.:|      :...:.:.:....|.||:.       .|..|:...|.....:...|....:|
Frog   948 DLDDLQESEAIDTSLSIVQRELDVEEHEGLQRAKRMRTGTSRAGKRKSREEDAEDPEDPTFTEYQ 1012

  Fly  1103 QQQQQHQQQ----------------------GVPPP----------------------------- 1116
            :::.:..:.                      .||.|
Frog  1013 EKESEFTRSSGDEDGSAVETLQQVVVTISDGSVPAPSCTVGLTNITVTPITTTAGTQFASLQPVA 1077

  Fly  1117 --HL------------LMT------------------------QHSVGPAPML----LTT----- 1134
              ||            ::|                        |.:.||.|:.    |||
Frog  1078 VGHLAASERQLQLDSSILTVTFDAVSGSAVLHNRPAELAIAASQDAAGPQPVAHFINLTTFVNSI 1142

  Fly  1135 -------ASQLP---------PPPPHHQQNSPSRLLQHGHAHPLQMQQQQQQQQQHSPKGLKSLP 1183
                   :|:.|         ..|||.:::.||               :|.:||...|..::.:|
Frog  1143 APLGGQISSEAPLTWRAVPAGETPPHPEEDQPS---------------EQTEQQSSGPHTVQEVP 1192

Fly 1184 1183
Frog 1193 1192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	39/127 (31%)
		C2H2 Zn finger	892..912	CDD:275368	7/19 (37%)
		zf-H2C2_2	904..929	CDD:290200	11/51 (22%)
		C2H2 Zn finger	920..940	CDD:275368	8/47 (17%)
		zf-H2C2_2	932..957	CDD:290200	10/25 (40%)
		C2H2 Zn finger	948..968	CDD:275368	6/19 (32%)
		zf-H2C2_2	960..985	CDD:290200	9/24 (38%)
		C2H2 Zn finger	976..996	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1004..1023	CDD:275368	8/18 (44%)
prdm15	XP_012813515.1	zf-C2H2	427..449	CDD:278523	3/21 (14%)
		C2H2 Zn finger	429..449	CDD:275368	3/19 (16%)
		C2H2 Zn finger	456..477	CDD:275368	2/24 (8%)
		C2H2 Zn finger	490..506	CDD:275368	3/15 (20%)
		C2H2 Zn finger	544..564	CDD:275368	4/28 (14%)
		COG5048	574..949	CDD:227381	84/405 (21%)
		C2H2 Zn finger	593..613	CDD:275368	9/42 (21%)
		C2H2 Zn finger	620..640	CDD:275368	1/19 (5%)
		C2H2 Zn finger	711..731	CDD:275368	0/19 (0%)
		C2H2 Zn finger	747..767	CDD:275368	7/19 (37%)
		C2H2 Zn finger	775..795	CDD:275368	5/19 (26%)
		zf-C2H2	775..795	CDD:278523	5/19 (26%)
		C2H2 Zn finger	803..823	CDD:275368	3/19 (16%)
		C2H2 Zn finger	831..851	CDD:275368	6/19 (32%)
		C2H2 Zn finger	859..879	CDD:275368	6/19 (32%)
		C2H2 Zn finger	888..909	CDD:275368	8/20 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910