DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Blimp-1 and prdm2a

DIOPT Version :9

Sequence 1:	NP_001261442.1	Gene:	Blimp-1 / 38638	FlyBaseID:	FBgn0035625	Length:	1216	Species:	Drosophila melanogaster
Sequence 2:	XP_001343122.2	Gene:	prdm2a / 100003615	ZFINID:	ZDB-GENE-081104-139	Length:	1499	Species:	Danio rerio

Alignment Length:	1302	Identity:	259/1302 - (19%)
Similarity:	443/1302 - (34%)	Gaps:	418/1302 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QEQQSGAIMKAANQPHHP--AHSHPLNHPHPHQHA----------------QPHPHPHPHPHHKL 65
            :::|:..:.::.:||..|  |:.:....|...:||                :....|...|..::
Zfish    58 KDKQNTQLFQSTSQPVSPNLANENQACQPSLTEHASMITQKYRTDLPLNVIKADLDPGSKPQGEI 122

  Fly    66 SARRARSRSRSRSPTPDGNQDYDVTRMREEDFERLAVYLVPDVQAERGLPNRADKTLPRSLTLKS 130
            :..|...|..|       :||.|    |......|:.|     ..:|...:|..:|..   ||.|
Zfish   123 ACPRCERRFTS-------SQDLD----RHIQTHALSTY-----HTQRFKCSRCRRTFS---TLFS 168

  Fly   131 SMVYS----------TPNVKTEGVWSSGVIPRGTRFGPFEGIPTSNYP--------------NDK 171
            ...:.          ..::.|....:..:..||      |.:.||..|              |||
Zfish   169 RRRHEKRHENGNKKIDSHINTACTANQNIPGRG------EPLKTSLNPEPKKCINAADAEQKNDK 227

  Fly   172 NKARYFWRVQGTRHITYGNIKIFKDDDYYYLDGSDRSQSNWMRYVASAYSLSVMNLVACQHQENI 236
            |                                ||...|:..:|...|:...:...   :||..|
Zfish   228 N--------------------------------SDIKASHICKYCKKAFRTYISQR---RHQCRI 257

  Fly   237 YFYTTRDILPNEELMVWYCKDFASRLGYDVDPETTIFGACKQAVEAEEEADEEEEEAEGE----- 296
            :   .|.:||..|..           ...|..|:.:....:.|.:::....|..:..|.|
Zfish   258 H---ERQLLPRGEFK-----------KVTVTQESEVQQLVETAQDSQTATPEHTDIQEREYMVDI 308

  Fly   297 ------------DGKPRYSMPAPEIPPDVAVSHI---------TYVMGLHLPVGAGNGPANGSVA 340
                        |||         |....|||:.         :.|:||:..:   ..||..:.|
Zfish   309 SSNISENLSFYIDGK---------IVSTSAVSNCEVIEMNSGGSAVIGLNAVI---ISPAQITQA 361

  Fly   341 GSVSGAT---PPPPTATPCCRR--SSPPAHVSTTTSTCNAHHPHIQHGRHASVIIGQDRSPMAS- 399
            ..:..:|   ...|:..|..||  |:||.            .|.|:....:..|:....|.:::
Zfish   362 LKLETSTSSFTSDPSEQPSTRRRTSTPPL------------LPQIKTELESESILSTSSSSLSTL 414

  Fly   400 SDKDTAGSPLSGLDHQMT---PQDGSVRSV---RSDEGYHSNEC-----HEDGLTPPEDSSDSES 453
            :...|:|:||      :|   ||  |:.:|   :....|.|.:.     ::||         |:|
Zfish   415 TLASTSGAPL------VTAHLPQ--SIETVAFSKEKTVYLSPKLKQLLQNQDG---------SKS 462

  Fly   454 EHNYVLDCSKKA------IAPKETVIAQAQKPSSSPPAVVMANTTTNSMISHSSPTATPICETDK 512
            ....:.|..|.:      :.|..|..|:.::.::|||               |||..|.....:.
Zfish   463 TFALIADGHKMSPPLSLTVLPATTTAAKFKRRTTSPP---------------SSPQQTHDLSVED 512

  Fly   513 NEYRKFKVKMPLKYEFKNKTCVKQEPSLKEVDQEMSLPQEEEEDQVMHP---------------E 562
            .:....|.|:| |.|......:..|.: :.::..|....|.:..|.:.|               :
Zfish   513 QDQDSTKAKIP-KMESYGLNLLSDEET-EPLNSPMDSSNEAQMQQQILPMDCSLLRTGGSSCNQQ 575

  Fly   563 PDSICPSTTTHLGDEHMLMMERERERERERIQEREPSNQQPASSTVIVLEHNSGGQARTIVPLSK 627
            |..:..|.....|:|..:          |.|.:...|.:.        |:::|.|     :.||
Zfish   576 PLDLSNSVGKKEGNEEFV----------ESILDLSISGKN--------LDYDSAG-----IYLS- 616

  Fly   628 PYYEPDPPGERYMRFGQPSSSILETILTSQH------RLEAAAAA------------ANACRQAN 674
                     :..:|..:|:||:|:.:|.:::      .:|..|.|            ..|...|:
Zfish   617 ---------QSTLRKSKPNSSMLKKVLMNEYGGVDIPSVEDPAGAGVFSVNDITNISVVAVSDAD 672

  Fly   675 A------------------ATPPPTSPTEMAYSYKKSQRYGNAVSPDSSSNLGQNPEQLS--SSA 719
            .                  :|||..:|..:        ..|..|.|..||. ..:|..:|  |:.
Zfish   673 LLNPEKLLFELALPPASINSTPPLLTPINI--------HPGPQVPPTQSSP-SSSPTFVSFLSNP 728

  Fly   720 VVVGEQEM--TRATMIKGECSPPPPSHH---HHNVIFS--------PSRHAAYLGAGEA---GGH 768
            .|...:::  ..:|::..:..||..|..   .::|..|        |...::..||.|.   ..|
Zfish   729 TVEPSKDIQTLHSTILVPDSVPPTGSDEGCIDNSVHLSQGDLNMTIPDWVSSATGALETLIPATH 793

  Fly   769 S---PSPGYPGYPHYGAAATSTFHSPPHSSHSPFD-----RQSNASSGAGSATNLHL-----LQT 820
            |   .||.:...|...|..|....|...|....|.     .|||.:|.|.....:.:     ||:
Zfish   794 SLSLQSPQWVTDPCELAQRTLVVDSVLASDSQIFSPSLPVNQSNVTSLAFPPNTVIIEYTVALQS 858

  Fly   821 STQMLNHPLMQPLTPLQRLS---PLRI--------SPPSSLSPDGNSCPRSGSPLSP--NSLA-- 870
            :..:|  |::| ...:|.||   |:..        |.|..|||:.|..|.:.:.|:|  .:|:
Zfish   859 TENIL--PVLQ-ANSVQNLSDKIPVDALKEDHYVSSEPQPLSPETNLLPETSTQLAPAEQTLSFT 920

  Fly   871 --SRGYRSLPYPLK---KKDGKMHYECNVCCKTFGQLSNLKVHLRTHSGERP----FKCNVCTKS 926
              :....:|...||   .|:|:..:|.:.|.|   |::.:|..|   ...:|    |.||||.|.
Zfish   921 NDTPTLSALTSVLKGESNKEGQEDFEPSDCSK---QVNKVKEEL---PSMQPFCKNFTCNVCEKP 979

  Fly   927 FTQLAHLQKHHLVHTGEKPHQCDICKKRFSSTSNLKTHLRLHSG-QKPYACDLCPQKFTQFVHLK 990
            |..:..|.:|...|:.|.|::|:.|.:.|.|.::|..|...:.| .|.|.|..|.::|....:|:
Zfish   980 FQSMKILSQHISEHSKEWPYKCEFCVQLFESDTSLLEHRSSYHGIGKIYVCKTCSKEFAFLCNLE 1044

  Fly   991 LHKR-LHTNDRPYVCQGCDKKYISASGLR----THWKTTSCKPNNLEEELAMAAAATSECLDKDH 1050
            .|:| ||..      |.|....:....||    ...||.:..|.....||...:..::..::::.
Zfish  1045 QHQRDLHPG------QECLHSDVIHGKLRPENHNSPKTETSDPGIPIAELKQESENSTSKVEENE 1103

  Fly  1051 PEPDSREAYEQLTQHMHPAVHPGLRHLSSGGQSPPRL-IPLGNHMAPQQQSHQQQQQQHQQQGVP 1114
            .:..|.|.:..            ::.::|||..|..: :.||.:             ||.....|
Zfish  1104 LDNTSEELFTT------------IKSMASGGVKPKGIDVRLGIN-------------QHYPSFKP 1143

  Fly  1115 PP 1116
            ||
Zfish  1144 PP 1145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Blimp-1	NP_001261442.1	SET	133..260	CDD:214614	23/150 (15%)
		C2H2 Zn finger	892..912	CDD:275368	5/19 (26%)
		zf-H2C2_2	904..929	CDD:290200	10/28 (36%)
		C2H2 Zn finger	920..940	CDD:275368	8/19 (42%)
		zf-H2C2_2	932..957	CDD:290200	8/24 (33%)
		C2H2 Zn finger	948..968	CDD:275368	6/19 (32%)
		zf-H2C2_2	960..985	CDD:290200	8/25 (32%)
		C2H2 Zn finger	976..996	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1004..1023	CDD:275368	4/22 (18%)
prdm2a	XP_001343122.2	C2H2 Zn finger	124..144	CDD:275368	7/30 (23%)
		C2H2 Zn finger	156..176	CDD:275368	5/22 (23%)
		C2H2 Zn finger	237..258	CDD:275368	4/23 (17%)
		PHA00733	<971..1024	CDD:177301	18/52 (35%)
		C2H2 Zn finger	973..993	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1001..1022	CDD:275368	6/20 (30%)
		C2H2 Zn finger	1030..1048	CDD:275368	5/17 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2461
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900