Protein Alignment mthl2 and adgrf7

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: XP_073789637.1
• Gene: adgrf7 / 613165
• ZFINID: ZDB-GENE-041001-214
• Length: 704
• Species: Danio rerio
• Alignment Length: 268
• Identity: 57/268 - (21%)
• Similarity: 108/268 - (40%)
• Gaps: 48/268 - (17%)

  Fly   227 SLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFLLLDLWEL-----------SLDFCKA 280
            |:.||:|.:.:...|.|.:......::.::..:......|:.|:..:           ..|.|.:
Zfish   431 SVACLILCLIIEAIVWKAVRRNDTSYMRHVSIVNIAISLLIADVCFIIGAAISKEQPTPADRCSS 495

  Fly   281 AGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRSER---AFLLYSCFAWAMPLALTGVTYL 342
            ..|..:.|.:|.|||:.|.:...:..:....:.|: |::.   ||||    .:..||.::.:|
Zfish   496 VVFFMHLFYLALFFWMLISALLLFYRVVMVLSQMS-RAKMMVIAFLL----GYGAPLLISVIT-- 553

  Fly   343 ADNVVNNEEWQPRVGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVLTAKHIIDSKRTLRKI 407
               |.:....|..|..:. ||:.......::.|..|.:.::..|:.:|::          .|.||
Zfish   554 ---VASTAGPQMYVSKQA-CWLNWNESRNLLAFVIPALTIVAINLVVFIV----------VLYKI 604

  Fly   408 -ARNEGRIQKLNSDKQN---YTQFLLLFT---VMGMSWSFEIFSYLVQREKLWVNIFLVADYFNW 465
             .|..|...:  .|.:|   ..:.:..||   ..|::|.|.|.:.:  ...|:|::  |...||.
Zfish   605 FKRRAGAATQ--PDWKNALVVARCVAFFTPALACGITWGFGIGTTV--SAGLFVHV--VFALFNS 663

  Fly   466 SQGVIIFV 473
            .||..|.|
Zfish   664 LQGFFILV 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053
		7tmB3_Methuselah-like	215..489	CDD:410632	57/268 (21%)
		TM helix 1	215..240	CDD:410632	4/12 (33%)
		TM helix 2	249..269	CDD:410632	1/19 (5%)
		TM helix 3	279..306	CDD:410632	7/26 (27%)
		TM helix 4	322..342	CDD:410632	6/19 (32%)
		TM helix 5	367..397	CDD:410632	4/29 (14%)
		TM helix 6	419..446	CDD:410632	8/32 (25%)
		TM helix 7	454..479	CDD:410632	8/20 (40%)
adgrf7	XP_073789637.1	None