DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl2 and adgre10

DIOPT Version :10

Sequence 1:NP_788462.2 Gene:mthl2 / 38636 FlyBaseID:FBgn0035623 Length:518 Species:Drosophila melanogaster
Sequence 2:XP_021333746.1 Gene:adgre10 / 569655 ZFINID:ZDB-GENE-090313-152 Length:690 Species:Danio rerio


Alignment Length:572 Identity:118/572 - (20%)
Similarity:197/572 - (34%) Gaps:186/572 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ASSKMLLSASILIYFLLNLQSSSAEIADCSFYDTVDISEGQR-LSNGSYLYEGLLIPAHLTAKYE 66
            |:.|.|:|:|         ..|.||:|          |.|.| |.:...|...|:.....:|...
Zfish   202 ATEKFLVSSS---------SDSPAELA----------SYGNRVLESTEKLISTLVKLTDTSANVS 247

  Fly    67 FKLLANGDKEQVPSHV--------RGCVCKLRTCVRFCCPHDHIMDM---------------GEC 108
            |.|      |.|..||        ...:.:|.|...|       ||:               ...
Zfish   248 FTL------ENVEGHVFMVGPNVTLNEILQLNTTNSF-------MDIDLIGIAKNNKDTRSAAVA 299

  Fly   109 YANMTTEENELLDPMLNVTLDDGSVVQRHYKKELM---VQWDLP--------KPCDDMFYLDNRD 162
            :.:.|..||.|.....|        .|::..|.:|   :...||        ||.:..|      
Zfish   300 FMSYTIMENLLKADFFN--------TQKNTNKTMMSTVISATLPKTSNTALTKPVNFTF------ 350

  Fly   163 IMDEYTLFENGRLLRHYDQ------VYLDKSEYCLQHRTFGEGNNNSIRIIPHNCLILPSRTGQT 221
                       |.:|.:|.      ||.:.||:                 |...|.:|.|.:..|
Zfish   351 -----------RHIREFDPSGSLSCVYWNISEW-----------------IVDGCSVLNSNSSHT 387

  Fly   222 V-----------VMITS-------------LICLVLTIAVY--------LCV-KKLMNLEGKCFI 253
            |           :|.||             |:|:::.:..:        ||. ...:|...:..|
Zfish   388 VCSCVHLSTFALIMQTSSSPPPSDLLDLLNLVCVIVGLVFFSLALLSFALCQWSPGVNNVARINI 452

  Fly   254 CYMMCLFFGYLFLLLDLWELSL-----DFCKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNPCAS 313
            |  :.|...:|.|||....|||     ..|.....|.:|..::||.|:.|.:...:.|:.|   .
Zfish   453 C--ISLLSAHLLLLLTQQFLSLIRPQQVLCVVIAGLLHFLFLSAFVWMFIEAVLLFICVKN---L 512

  Fly   314 MNIRSERAFLLYSCFAWAM--PLALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKS---WSAMV 373
            ..:.|.:..:|.:.|...:  .:||.||:.....|...      .|.| .|||....   ||   
Zfish   513 SQVSSRKKEVLSNGFLCVIGYVVALIGVSVSIGMVPEG------YGSE-QCWIKMDKGFFWS--- 567

  Fly   374 YFYGPMVLLILFNITMFVLTAKHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSW 438
             |.||:.:::..|:.:|:..:.::   ...|:|:   ...:.:|...|....:.|..|.::|..|
Zfish   568 -FLGPVCVILGLNVILFISISIYL---NSALKKL---NAEVSQLKQTKVMVFKTLGQFVILGCPW 625

  Fly   439 SFEIFSYLVQREKLWVNIFLVADYFNWSQGVIIFVLFILRRKTLVLFKKQIF 490
            ....|:::....::   :|::   .|..||..||:::.:....:....|:||
Zfish   626 ILGFFAHVNMVVEI---VFII---INSQQGTFIFLIYCVLSTEIRQQYKKIF 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl2NP_788462.2 Methuselah_N 31..211 CDD:429053 39/220 (18%)
7tmB3_Methuselah-like 215..489 CDD:410632 66/316 (21%)
TM helix 1 215..240 CDD:410632 8/56 (14%)
TM helix 2 249..269 CDD:410632 6/19 (32%)
TM helix 3 279..306 CDD:410632 6/26 (23%)
TM helix 4 322..342 CDD:410632 6/21 (29%)
TM helix 5 367..397 CDD:410632 7/32 (22%)
TM helix 6 419..446 CDD:410632 6/26 (23%)
TM helix 7 454..479 CDD:410632 6/24 (25%)
adgre10XP_021333746.1 TM helix 6 611..631 CDD:410628 4/19 (21%)
TM helix 7 635..660 CDD:410628 6/30 (20%)
GPS 360..406 CDD:470616 13/62 (21%)
7tm_GPCRs 413..672 CDD:475119 62/287 (22%)
TM helix 1 413..437 CDD:410628 2/23 (9%)
TM helix 2 446..467 CDD:410628 7/22 (32%)
TM helix 3 481..503 CDD:410628 6/21 (29%)
TM helix 4 527..543 CDD:410628 5/15 (33%)
TM helix 5 561..584 CDD:410628 6/26 (23%)

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