Protein Alignment mthl2 and LOC4576098

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: XP_001237342.4
• Gene: LOC4576098 / 4576098
• VectorBaseID: AGAMI1_013637
• Length: 1351
• Species: Anopheles gambiae
• Alignment Length: 566
• Identity: 120/566 - (21%)
• Similarity: 198/566 - (34%)
• Gaps: 155/566 - (27%)

  Fly    22 QSSSAEIADCSFYDTVDISEGQRLSNG---SYLYEGLLIPAHLTAKYEFKLLANGDKE---QVPS 80
            ::.:..:.|.|  |..:.||.:...:|   .|||        :....| .|||..|.|   .:|.
Mosquito   826 RARNLSLEDLS--DAAENSESEEDFSGYTLRYLY--------MNQSLE-DLLAESDLEIGSFIPQ 879

  Fly    81 HVRGCVCKLRTCVRFCCPHDHIMDMGECYANMTT--EENELLDPMLN---------VTL------ 128
            ||...:.:|.|..|  .|.|...|......:.||  ...|..||.::         :|:
Mosquito   880 HVIEGLDELNTAFR--APDDEEQDPDAPDESTTTLPSPGEHPDPPVSPAPPPLRVIITIYYNDHA 942

  Fly   129 ----DDGSVVQRHYKKELMVQWDLP---KPCDDMFYLDNRDIMDE------YTLFE--NGRLLRH 178
                .:|::.:.:.|   ::...||   ....|...:..|::..|      |..||  |.....|
Mosquito   943 FRETKNGTIARPNSK---IISVSLPGYGSRMPDEIPIYTREMARELPSRCGYWSFEADNATEFGH 1004

  Fly   179 --YDQV-YLDKSEY------CLQHRTFGEGNNNSIRIIPHNCLILPSRTGQTVVMITSLICLVLT 234
              ||:. .|:.|:.      |. |.|........|:::            :||.:...||....|
Mosquito  1005 WSYDECRLLNASDRGVSLCGCF-HLTSFSRLTKDIQMV------------ETVGVSQKLIADQGT 1056

  Fly   235 IAVYL-----CVKKLMNLEG-----------------------KCFICYMMCLFFGYLFLL---L 268
            :|:.:     |...|:.:.|                       .|.|...|.:    :||.   :
Mosquito  1057 LALDIITAIGCSMSLLGVMGIFATAALFPSWRVKASSKILLQLSCAIAIEMII----IFLEGPDI 1117

  Fly   269 DLWELSLDFCKAAGFLGYFFVMAAFFWLSIIS----RHYWKCLTNPCASMNIRSERAFLLYSCFA 329
            |...:|...|...|.:.::.::..|.|:.|.:    ..|.|.|.      .:|.....|..:...
Mosquito  1118 DQNRISQIECALLGGIFHYIILVTFMWMLITAYLQFMRYVKVLG------QLRPAHFILKATVCC 1176

  Fly   330 WAMPLALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKS-WSAMVYFYG---PMVLLILFNITMF 390
            |..||.:..:....|..:    :..|......|:.:.:: |      ||   |:..:|..|:..|
Mosquito  1177 WGGPLLIVALFLSLDYTL----YLKRDNLSDICYPHGRALW------YGLLLPIGAIIFVNLVSF 1231

  Fly   391 VLTAKHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLV--QREKLW 453
            |:...||......|.|.|.:...:.:|...       :.||.::|:.|   ||..|.  ..|||:
Mosquito  1232 VIVLYHICTIPSNLTKSADHAMTLAQLRLS-------VFLFFLLGLPW---IFGMLTTGTEEKLF 1286

  Fly   454 VNIF-LVADYFNWSQGVIIFVLFILRRKTLVLF---KKQIFPKQRA 495
            ..:| |.|..    ||.::||.|::...:...|   |.|..|..||
Mosquito  1287 AYLFCLTAPV----QGFVLFVYFVVMDPSARRFWCRKLQRLPCCRA 1328

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	49/226 (22%)
		7tmB3_Methuselah-like	215..489	CDD:410632	66/318 (21%)
		TM helix 1	215..240	CDD:410632	6/29 (21%)
		TM helix 2	249..269	CDD:410632	6/45 (13%)
		TM helix 3	279..306	CDD:410632	5/30 (17%)
		TM helix 4	322..342	CDD:410632	4/19 (21%)
		TM helix 5	367..397	CDD:410632	8/33 (24%)
		TM helix 6	419..446	CDD:410632	6/26 (23%)
		TM helix 7	454..479	CDD:410632	8/25 (32%)
LOC4576098	XP_001237342.4	None