Protein Alignment mthl2 and Mayo

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_651842.3
• Gene: Mayo / 43678
• FlyBaseID: FBgn0039818
• Length: 802
• Species: Drosophila melanogaster
• Alignment Length: 336
• Identity: 73/336 - (21%)
• Similarity: 145/336 - (43%)
• Gaps: 52/336 - (15%)

  Fly   204 IRIIPHNCLILP--SRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFL 266
            |.|.|.|..:|.  |..|.::.:: .::.:.||.|::...:...:.:....:|..|||.. .||:
  Fly   491 ILITPINEKVLDIISIVGCSLSLL-GILGIFLTAALFKSWRSQASTKVLLHLCLAMCLQM-MLFV 553

  Fly   267 LLDLWELSLDF--------CKAAGFLGYFFVMAAFFWLSIIS-RHYWKCLTNPCASMNI-RSERA 321
            .|:..::|...        |.|.|....:.::..|.|:.||: ..:.:.:|    .:.| |..|.
  Fly   554 FLNTDDVSEALVVNGNTVRCVALGAAMQYSILVLFSWMLIIAFLQFQRYVT----VIGIERPPRY 614

  Fly   322 FLLYSCFAWAMPLALTGVTYLADNVVNNEEWQPRVG----DEGHCWIYTKSWSAMVYFYGPMVLL 382
            .|..:..||.:||..|.:..|.|    .:.:.|...    |.|.|  |...:..:.....|:.|:
  Fly   615 ILKAAIVAWLLPLVPTLLVALID----PDSYVPSAAQLSTDTGIC--YPSGYGLIFGVVLPVTLI 673

  Fly   383 ILFNITMFVLTAKHIIDSKRTLRKIARNEGR--IQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSY 445
            .:.|:.:||.....|  |....:.|.:||.:  ::::...       ::||.::|::|.|.||::
  Fly   674 TVCNLVIFVYVFYSI--SHSLSQSIHKNEKKMVVKQIRLS-------IMLFFLLGLTWIFGIFAF 729

  Fly   446 LVQREKLWVNIFLVADYFNWSQGVIIFVLFIL-----RRKTLVLFKKQIFPKQRAFSRSATQSTI 505
            : |....:..:|.:....   ||.::|:.|:|     ||    |:...|.|.:.........:.:
  Fly   730 M-QAGVAFSYLFCITATM---QGFVMFIYFVLLDSTNRR----LWVGLICPTKMELDVQKRTTEL 786

  Fly   506 ESISQTKRHFN 516
            :|::.:..::|
  Fly   787 QSMTTSSTNYN 797

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	3/6 (50%)
		7tmB3_Methuselah-like	215..489	CDD:410632	64/296 (22%)
		TM helix 1	215..240	CDD:410632	5/26 (19%)
		TM helix 2	249..269	CDD:410632	6/19 (32%)
		TM helix 3	279..306	CDD:410632	6/27 (22%)
		TM helix 4	322..342	CDD:410632	6/19 (32%)
		TM helix 5	367..397	CDD:410632	5/29 (17%)
		TM helix 6	419..446	CDD:410632	7/26 (27%)
		TM helix 7	454..479	CDD:410632	6/29 (21%)
Mayo	NP_651842.3	7tmB2_Adhesion	498..766	CDD:320168	64/296 (22%)
		TM helix 1	500..525	CDD:320168	5/25 (20%)
		TM helix 2	535..557	CDD:320168	7/22 (32%)
		TM helix 3	574..600	CDD:320168	6/25 (24%)
		TM helix 4	615..635	CDD:320168	6/19 (32%)
		TM helix 5	659..688	CDD:320168	5/28 (18%)
		TM helix 6	704..730	CDD:320168	7/32 (22%)
		TM helix 7	734..759	CDD:320168	6/27 (22%)