Protein Alignment mthl2 and Adgrf2

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: XP_017173054.1
• Gene: Adgrf2 / 435529
• MGIID: 2182728
• Length: 673
• Species: Mus musculus
• Alignment Length: 354
• Identity: 82/354 - (23%)
• Similarity: 134/354 - (37%)
• Gaps: 100/354 - (28%)

  Fly   203 SIRIIPHNCLILPSRT-----GQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYM--MCLF 260
            ||.:.| |.|..|..|     |..:.:.:.:|||.:.:.|:..|.|..       |.|:  :|:.
Mouse   368 SILMSP-NTLESPVLTYITYIGLGISICSLIICLAIEVLVWSQVTKTE-------ISYLRHLCIA 424

  Fly   261 -FGYLFLLLDLWELSLDF----------CKAAGFLGYFFVMAAFFWL----------SIISRHYW 304
             .....|:.|.|.:...|          |.||.|..:||.::.|||:          .:|..|
Mouse   425 NIAATLLMADAWFIVASFLSGPVLHHNGCVAATFFVHFFYLSVFFWMLAKALLILYGILIVFH-- 487

  Fly   305 KCLTNPCASMNIRSERAFLLYSCFAWAMPLALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKSW 369
             .|...|...::.|    :.|.|     ||.:..:| ||.........:|..     ||:.....
Mouse   488 -TLPKSCLVASLFS----VGYGC-----PLVIAIIT-LAVTEPGKGYLRPEA-----CWLNWDMT 536

  Fly   370 SAMVYFYGPMVLLILFN---ITMFVL-TAKHIIDSK-----RTLRKIARNEGRIQKLNSDKQNYT 425
            .|::.|..|.:.:::.|   :||.:: |.:..|.|.     |.:.:|.:|
Mouse   537 KALLAFVVPALAIVVVNLITVTMVIIKTQRAAIGSSMFQEVRAIVRICKN--------------- 586

  Fly   426 QFLLLFTVMGMSWSFEIFSYLVQREKLWVNIFLVADYFNWSQGVIIFVLFILRRKTLVLFKKQIF 490
             ..:|..::|::|.|.| :.::....|..:|  :....|..||     .|||      ||...:.
Mouse   587 -IAILTPLLGLTWGFGI-ATVINGHSLAFHI--IFSLLNALQG-----FFIL------LFGTILD 636

  Fly   491 PKQRAFSRSATQSTIES---ISQTKRHFN 516
            ||    .|.|.:|.|.|   ||:....|:
Mouse   637 PK----IREALKSRITSAKWISRVSEDFS 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	3/7 (43%)
		7tmB3_Methuselah-like	215..489	CDD:410632	67/310 (22%)
		TM helix 1	215..240	CDD:410632	7/29 (24%)
		TM helix 2	249..269	CDD:410632	4/22 (18%)
		TM helix 3	279..306	CDD:410632	10/36 (28%)
		TM helix 4	322..342	CDD:410632	5/19 (26%)
		TM helix 5	367..397	CDD:410632	7/33 (21%)
		TM helix 6	419..446	CDD:410632	5/26 (19%)
		TM helix 7	454..479	CDD:410632	7/24 (29%)
Adgrf2	XP_017173054.1	GPS	326..373	CDD:470616	2/4 (50%)
		7tmB2_GPR111_115	378..644	CDD:320660	71/324 (22%)
		TM helix 1	380..405	CDD:320660	5/24 (21%)
		TM helix 2	420..442	CDD:320660	4/21 (19%)
		TM helix 3	454..481	CDD:320660	8/26 (31%)
		TM helix 4	495..515	CDD:320660	6/29 (21%)
		TM helix 5	535..564	CDD:320660	6/28 (21%)
		TM helix 6	580..606	CDD:320660	7/42 (17%)
		TM helix 7	611..636	CDD:320660	10/37 (27%)