Protein Alignment mthl2 and mthl5

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_001287291.1
• Gene: mthl5 / 41438
• FlyBaseID: FBgn0037960
• Length: 497
• Species: Drosophila melanogaster
• Alignment Length: 474
• Identity: 113/474 - (23%)
• Similarity: 178/474 - (37%)
• Gaps: 106/474 - (22%)

  Fly    78 VPSHVRGC------------VCKLRTCVRFCCPHDHIMDMGECYANMTTEENELLDPMLNVTLDD 130
            |.|||...            |...:.|.:|....||     ||   ....|.:...||..   ..
  Fly    41 VTSHVTSAGSSTALSSDPNLVLVNKCCEKFEIHVDH-----EC---QQVNETDYFQPMFT---SY 94

  Fly   131 GSVVQRHYKKELMVQWDLPKPCDDM------FYLDNRDIMDEYTLFENGRLLRHY---------- 179
            |....|..|.:.::  .:|. |..|      .|..:   .|:..|.::|| ||||
  Fly    95 GGEQNRPVKFKFVI--GIPN-CGSMQMWPIYHYAGS---SDKLVLLDDGR-LRHYTNAENEAEER 152

  Fly   180 ---------------DQVY--LDKSEYCLQHRTFGEGNNNSIRIIPHNCL------------ILP 215
                           :.:|  .||..||:...|...|..|.  :..:.||            :|.
  Fly   153 HGIQSDYEEDIAGSLEPLYHDYDKGLYCIDKATSSTGEENV--LFANICLARKEIKWSDSNFLLR 215

  Fly   216 SRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFLLLDLW-ELS--LDF 277
            .........|:.:|.||:.|..::......:|.|.......|||.......|:.:: ||:  :.|
  Fly   216 KILNPIFHGISLVILLVIAIIYFILPTLSRDLVGNIVTTIAMCLMVSQAADLVRIFTELTSHVSF 280

  Fly   278 CKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRSERAFLLYSCFAWAMPLALTGVTYL 342
            . .|..:..|.::||||||:....:.||...:....:.:...|.:..||.:||.....:..:...
  Fly   281 I-VADIILCFSLLAAFFWLNSFGFYIWKTFRSRNVFLRVTDGRKYCYYSAYAWGCTATMAALAVF 344

  Fly   343 ADNVVNNEEWQPR--VGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVLTAKHIIDSKRTLR 405
            |...::.|.::..  ||::     .|..|..:..|:.|:...||.||..:|.|.|.|  ::||:
  Fly   345 AHFFLDAESYKQEHMVGEQ-----ETIGWLGICIFFAPIACTILVNIFFYVTTRKLI--NRRTV- 401

  Fly   406 KIARNEGRI-QKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLVQREKLWVNIFLVADYFNWSQGV 469
                 .||| .||   |.|:..|.|:..||.::|.|.|.|:|.....|:.:|.:     |..|..
  Fly   402 -----YGRIAHKL---KANFIMFSLMLLVMSIAWLFLIMSWLQMEGLLYAHIVV-----NALQTP 453

  Fly   470 IIFVLFILR-RKTLVLFKK 487
            ::..:.:|| |....|.||
  Fly   454 LLLYICVLRQRHVTFLLKK 472

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	37/177 (21%)
		7tmB3_Methuselah-like	215..489	CDD:410632	73/280 (26%)
		TM helix 1	215..240	CDD:410632	5/24 (21%)
		TM helix 2	249..269	CDD:410632	5/19 (26%)
		TM helix 3	279..306	CDD:410632	9/26 (35%)
		TM helix 4	322..342	CDD:410632	4/19 (21%)
		TM helix 5	367..397	CDD:410632	10/29 (34%)
		TM helix 6	419..446	CDD:410632	10/26 (38%)
		TM helix 7	454..479	CDD:410632	5/25 (20%)
mthl5	NP_001287291.1	7tmB3_Methuselah-like	215..474	CDD:410632	73/280 (26%)
		TM helix 1	215..239	CDD:410632	5/23 (22%)
		TM helix 2	249..271	CDD:410632	5/21 (24%)
		TM helix 3	281..308	CDD:410632	9/27 (33%)
		TM helix 4	324..344	CDD:410632	4/19 (21%)
		TM helix 5	371..396	CDD:410632	9/24 (38%)
		TM helix 6	409..435	CDD:410632	11/28 (39%)
		TM helix 7	438..463	CDD:410632	5/29 (17%)