Protein Alignment mthl2 and mthl4

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_788394.1
• Gene: mthl4 / 36960
• FlyBaseID: FBgn0034219
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 500
• Identity: 261/500 - (52%)
• Similarity: 344/500 - (68%)
• Gaps: 24/500 - (4%)

  Fly    13 ILIYFLLNLQSSSAEIADCSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLANGDKEQ 77
            |.:.||| :..|:|||..|.|:||||||:..|.||||||||||||||||||:|::||||:..||:
  Fly     6 IAVLFLL-MPKSNAEIPGCDFFDTVDISKAPRFSNGSYLYEGLLIPAHLTAEYDYKLLADDSKEK 69

  Fly    78 VPSHVRGCVCKLRTCVRFCCPHDHIMDMGECYANMTTEENELLDPMLNVTLDDGSVVQRHYKKEL 142
            |.||||||.|.||.|:|||||....|...:||.:|:.:|....||.:||||.|||||:||:|::|
  Fly    70 VASHVRGCACHLRPCIRFCCPQYQKMQKSKCYGDMSEDELNKHDPFVNVTLSDGSVVRRHFKEDL 134

  Fly   143 MVQWDLPKP-CDDMFYLDNRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNSIRI 206
            :||.||.|| |..|::|::....:|:||||||.||||:|:|.|.|.|||:||.:|   .::||||
  Fly   135 IVQSDLAKPGCPRMYFLNHELPGNEFTLFENGSLLRHWDKVELSKREYCVQHLSF---KDDSIRI 196

  Fly   207 IPHNCLILP--SRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFLLLD 269
            .||.|.:..  |||.:||.::.||||::|||:|||.|:||.||.|||||||:..||.||.||:|:
  Fly   197 APHFCPLSSEHSRTWKTVAIVISLICIILTISVYLYVEKLRNLHGKCFICYLASLFLGYFFLVLN 261

  Fly   270 LWELSLDFCKAAGFLGYFFVMAAFFWLSIISRHY-------WKCLTNPCASMNIRSERAFLLYSC 327
            :|:.|..||..|||||||.|||||||||:|..|.       ..||      ..:..|..|..|:.
  Fly   262 VWKYSSGFCVTAGFLGYFSVMAAFFWLSVIGIHLRIKFSLASNCL------HRLLPENPFRAYNL 320

  Fly   328 FAWAMPLALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVL 392
            :||.:||.:|.:||.||.||.||:.:||||...:|||||...:.|:||||||:|||.|||.||||
  Fly   321 YAWGIPLIMTAITYTADQVVKNEKLRPRVGVGKNCWIYTGDMTVMIYFYGPMLLLIAFNIIMFVL 385

  Fly   393 TAKHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLVQREKLWVNIF 457
            :|.:|.:.|:.::.:...:...|::| |:|.:..||.||.:||:||||||.|:|:.:::.|....
  Fly   386 SAIYIYNIKKNVKGLVHKQQTNQQIN-DQQMFAIFLRLFILMGLSWSFEILSFLLTKQQAWARAL 449

  Fly   458 LVADYFNWSQGVIIFVLFILR---RKTLVLFKKQIFPKQRAFSRS 499
            :||||||||||.||||||||:   .|.::...:|..|.....|||
  Fly   450 MVADYFNWSQGTIIFVLFILKPSILKLIIAGGRQNLPGSHHNSRS 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	106/180 (59%)
		7tmB3_Methuselah-like	215..489	CDD:410632	141/285 (49%)
		TM helix 1	215..240	CDD:410632	14/26 (54%)
		TM helix 2	249..269	CDD:410632	13/19 (68%)
		TM helix 3	279..306	CDD:410632	18/33 (55%)
		TM helix 4	322..342	CDD:410632	8/19 (42%)
		TM helix 5	367..397	CDD:410632	18/29 (62%)
		TM helix 6	419..446	CDD:410632	15/26 (58%)
		TM helix 7	454..479	CDD:410632	18/27 (67%)
mthl4	NP_788394.1	Methuselah_N	23..201	CDD:429053	106/180 (59%)
		7tmB3_Methuselah-like	205..477	CDD:410632	141/278 (51%)
		TM helix 1	207..232	CDD:410632	14/24 (58%)
		TM helix 2	241..263	CDD:410632	14/21 (67%)
		TM helix 3	271..298	CDD:410632	18/26 (69%)
		TM helix 4	315..335	CDD:410632	8/19 (42%)
		TM helix 5	361..390	CDD:410632	18/28 (64%)
		TM helix 6	411..438	CDD:410632	16/27 (59%)
		TM helix 7	446..471	CDD:410632	18/24 (75%)