DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl2 and Cirl

DIOPT Version :10

Sequence 1:NP_788462.2 Gene:mthl2 / 38636 FlyBaseID:FBgn0035623 Length:518 Species:Drosophila melanogaster
Sequence 2:NP_001260807.1 Gene:Cirl / 35846 FlyBaseID:FBgn0033313 Length:1711 Species:Drosophila melanogaster


Alignment Length:402 Identity:76/402 - (18%)
Similarity:139/402 - (34%) Gaps:127/402 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   162 DIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFG--EGNNNSIRIIPHNCLILPSRTGQTVVM 224
            |::||:                        ||..|.  :||   :||.               :.
  Fly   749 DVVDEH------------------------QHSLFTMFDGN---MRIF---------------IY 771

  Fly   225 ITSLICLVLTIAVYLCVKKLMNLEGKCFI----------CYMMCLFFGYLFLL-LDLWELSLDFC 278
            |:..||:|. |.:.|...||.|   ..|:          .|:..|....|||| ::..|.|: ||
  Fly   772 ISIGICVVF-IVIALLTLKLFN---GVFVKSARTSIYTSIYLCLLAIELLFLLGIEQTETSI-FC 831

  Fly   279 KAAGFLGYFF---VMAAFFWLSIISRHYWKCLTNPCASMNIRSERAFLLYSCFAWAMPLALTGVT 340
               ||:..|.   :::...|....:.|.:..||:....:.:........|...::.:.|::..::
  Fly   832 ---GFITIFLHCAILSGTAWFCYEAFHSYSTLTSDELLLEVDQTPKVNCYYLLSYGLSLSVVAIS 893

  Fly   341 YLAD--NVVNNEEWQPRVGDEGHCWIYTKSWSAMVYFYGPMVL--LILFNITMFVLTAKHIIDSK 401
            .:.|  ....|:              |.....|...||...|:  |:.|...:.......||..:
  Fly   894 LVIDPSTYTQND--------------YCVLMEANALFYATFVIPVLVFFVAAIGYTFLSWIIMCR 944

  Fly   402 RTLRKIARNE-GRIQKLNSDKQNYTQFLLLFTVMGMSWSF------------EIFSYLVQREKLW 453
            ::...:...| .|:..:..|.:....||||.:.:..|..|            :::.|        
  Fly   945 KSRTGLKTKEHTRLASVRFDIRCSFVFLLLLSAVWCSAYFYLRGAKMDDDTADVYGY-------- 1001

  Fly   454 VNIFLVADYFNWSQGVIIFVLFILRRKTLVL-FKKQI-----FPKQRAFSRSA-----------T 501
              .|:.   ||...|:.|||...::.:.:.. ::|.:     .||....|:::           |
  Fly  1002 --CFIC---FNTLLGLYIFVFHCIQNEKIRREYRKYVRQHAWLPKCLRCSKTSISSGIVTGNGPT 1061

  Fly   502 QSTIESISQTKR 513
            ..|:.|:|.:|:
  Fly  1062 AGTLCSVSTSKK 1073

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl2NP_788462.2 Methuselah_N 31..211 CDD:429053 10/50 (20%)
7tmB3_Methuselah-like 215..489 CDD:410632 58/305 (19%)
TM helix 1 215..240 CDD:410632 5/24 (21%)
TM helix 2 249..269 CDD:410632 7/30 (23%)
TM helix 3 279..306 CDD:410632 5/29 (17%)
TM helix 4 322..342 CDD:410632 2/19 (11%)
TM helix 5 367..397 CDD:410632 6/31 (19%)
TM helix 6 419..446 CDD:410632 7/38 (18%)
TM helix 7 454..479 CDD:410632 7/24 (29%)
CirlNP_001260807.1 Gal_Rha_Lectin_dCirl 22..113 CDD:438687
GAIN 451..682 CDD:465137
GPS 705..752 CDD:197639 1/2 (50%)
7tmB2_CELSR_Adhesion_IV 763..1035 CDD:320557 62/324 (19%)
TM helix 1 765..790 CDD:320557 9/43 (21%)
TM helix 2 801..823 CDD:320557 6/21 (29%)
TM helix 3 832..859 CDD:320557 5/26 (19%)
TM helix 4 875..895 CDD:320557 2/19 (11%)
TM helix 5 913..942 CDD:320557 6/28 (21%)
TM helix 6 960..987 CDD:320557 7/26 (27%)
TM helix 7 997..1022 CDD:320557 8/37 (22%)
Herpes_TAF50 <1219..1365 CDD:308764
Blue background indicates that the domain is not in the aligned region.

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