Protein Alignment mthl2 and Adgrl1

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: XP_030099484.1
• Gene: Adgrl1 / 330814
• MGIID: 1929461
• Length: 1543
• Species: Mus musculus
• Alignment Length: 298
• Identity: 75/298 - (25%)
• Similarity: 123/298 - (41%)
• Gaps: 48/298 - (16%)

  Fly   191 LQHRTFGEGNNNSIRIIPHNCLILPSRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICY 255
            :.||...:|..|.        |:|...|  .|.::.||:||.:.|:.:..::.|...........
Mouse   916 MAHREIYQGRINE--------LLLSVIT--WVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNL 970

  Fly   256 MMCLFFGYLFLLLDL----WELSLDFCKA-AGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMN 315
            .:.||...|..|:.:    :|::   |.. ||.|.||| :|||.||.:...|.:..|.....|..
Mouse   971 CINLFLAELLFLVGIDKTQYEVA---CPIFAGLLHYFF-LAAFSWLCLEGVHLYLLLVEVFESEY 1031

  Fly   316 IRSERAFLLYSCFAWAMPLALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKS---WSAMVYFYG 377
            .|::..:|...||    |..:.|:....|        ....|.|..||:...:   ||    |.|
Mouse  1032 SRTKYYYLGGYCF----PALVVGIAAAID--------YRSYGTEKACWLRVDNYFIWS----FIG 1080

  Fly   378 PMVLLILFNITMFVLTAKHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSFEI 442
            |:..:|:.|:...::|...:|.|...|:.   :..|:..:.|........|.|   :|::|:|.:
Mouse  1081 PVSFVIVVNLVFLMVTLHKMIRSSSVLKP---DSSRLDNIKSWALGAIALLFL---LGLTWAFGL 1139

  Fly   443 FSYLVQREKLWVNIFLVADYFNWSQGVIIFVLFILRRK 480
            .  .:.:|.: |..:|... ||..|||.|||.....:|
Mouse  1140 L--FINKESV-VMAYLFTT-FNAFQGVFIFVFHCALQK 1173

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	4/19 (21%)
		7tmB3_Methuselah-like	215..489	CDD:410632	69/274 (25%)
		TM helix 1	215..240	CDD:410632	7/24 (29%)
		TM helix 2	249..269	CDD:410632	4/19 (21%)
		TM helix 3	279..306	CDD:410632	12/27 (44%)
		TM helix 4	322..342	CDD:410632	5/19 (26%)
		TM helix 5	367..397	CDD:410632	8/32 (25%)
		TM helix 6	419..446	CDD:410632	6/26 (23%)
		TM helix 7	454..479	CDD:410632	10/24 (42%)
Adgrl1	XP_030099484.1	OLF	214..470	CDD:470611
		PLN02550	491..>573	CDD:178165
		HormR	548..611	CDD:214468
		GAIN	621..845	CDD:465137
		GPS	869..921	CDD:197639	2/4 (50%)
		7tmB2_Latrophilin-1	928..1185	CDD:320673	71/286 (25%)
		TM helix 1	930..955	CDD:320673	8/26 (31%)
		TM helix 2	964..986	CDD:320673	4/21 (19%)
		TM helix 3	995..1022	CDD:320673	12/27 (44%)
		TM helix 4	1034..1054	CDD:320673	5/23 (22%)
		TM helix 5	1071..1100	CDD:320673	8/32 (25%)
		TM helix 6	1116..1143	CDD:320673	6/31 (19%)
		TM helix 7	1147..1172	CDD:320673	10/26 (38%)
		Latrophilin	1184..1543	CDD:460538