DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl2 and ADGRE2

DIOPT Version :10

Sequence 1:NP_788462.2 Gene:mthl2 / 38636 FlyBaseID:FBgn0035623 Length:518 Species:Drosophila melanogaster
Sequence 2:XP_054176753.1 Gene:ADGRE2 / 30817 HGNCID:3337 Length:892 Species:Homo sapiens


Alignment Length:438 Identity:83/438 - (18%)
Similarity:159/438 - (36%) Gaps:109/438 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   110 ANMTTEENELLDPMLNVTLDDGSVVQRHYKKELMVQWD---------LPKPCDDMFYLDNRDIMD 165
            |.::..:.:.|...:..|....||:.|  :|.|.|.|:         ....|..:...|...|..
Human   520 AFLSNNDTQNLSSPVTFTFSHRSVIPR--QKVLCVFWEHGQNGCGHWATTGCSTIGTRDTSTICR 582

  Fly   166 EYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNSIRIIPHNCLILPSRTGQTVVMITSLIC 230
            ...|.....|:.|||   :.:.:..|...|:                     .|.:|    ||:|
Human   583 CTHLSSFAVLMAHYD---VQEEDPVLTVITY---------------------MGLSV----SLLC 619

  Fly   231 LVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFLLLDLWELSLD------FCK-AAGFLGYFF 288
            |:|....:|..|.:.|......:...:|||..:|..|     :::|      .|. .||.|.|.:
Human   620 LLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHLLFL-----VAIDQTGHKVLCSIIAGTLHYLY 679

  Fly   289 VMAAFFWLSIISRHYWKCLTNPCASMNIRSERAFLLYSCF--AWAMPLALTGVTYLADNVVNNEE 351
             :|...|:.:.:.:.:....| ...:|..|...|:....|  .:.:|.....::..:        
Human   680 -LATLTWMLLEALYLFLTARN-LTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAAS-------- 734

  Fly   352 WQPRV-GDEGHCWIYTKS---WSAMVYFYGPM-----VLLILFNITMFVLTAKHIIDSKRTLRKI 407
             :|.: |....||:..:.   |.    |.||:     |.|:||.:|:::|               
Human   735 -RPHLYGTPSRCWLQPEKGFIWG----FLGPVCAIFSVNLVLFLVTLWIL--------------- 779

  Fly   408 ARNEGRIQKLNSDKQNYTQFLLL-------FTVMGMSWSFEIFSYLVQREKLWVNIFLVADYFNW 465
               :.|:..|||:........:|       ..::|.:|...|.. :....::...:|.:   .|.
Human   780 ---KNRLSSLNSEVSTLRNTRMLAFKATAQLFILGCTWCLGILQ-VGPAARVMAYLFTI---INS 837

  Fly   466 SQGVIIFVLFILRRKTLVLFKKQIFPKQRAFSRSATQSTIESISQTKR 513
            .|||.||:::.|..:.:   ::|.....:...:..|:|.:.::|.:.:
Human   838 LQGVFIFLVYCLLSQQV---REQYGKWSKGIRKLKTESEMHTLSSSAK 882

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl2NP_788462.2 Methuselah_N 31..211 CDD:429053 20/109 (18%)
7tmB3_Methuselah-like 215..489 CDD:410632 59/298 (20%)
TM helix 1 215..240 CDD:410632 7/24 (29%)
TM helix 2 249..269 CDD:410632 5/19 (26%)
TM helix 3 279..306 CDD:410632 6/27 (22%)
TM helix 4 322..342 CDD:410632 3/21 (14%)
TM helix 5 367..397 CDD:410632 10/37 (27%)
TM helix 6 419..446 CDD:410632 5/33 (15%)
TM helix 7 454..479 CDD:410632 8/24 (33%)
ADGRE2XP_054176753.1 EGF_CA 136..168 CDD:429571
EGF_CA 188..>220 CDD:214542
EGF_CA 232..263 CDD:429571
EGF_CA 281..312 CDD:429571
GPS 548..598 CDD:197639 12/52 (23%)
7tmB2_EMR 602..864 CDD:320555 62/331 (19%)
TM helix 1 604..629 CDD:320555 9/49 (18%)
TM helix 2 638..660 CDD:320555 5/26 (19%)
TM helix 3 669..696 CDD:320555 6/27 (22%)
TM helix 4 713..733 CDD:320555 2/19 (11%)
TM helix 5 750..773 CDD:320555 7/26 (27%)
TM helix 6 797..822 CDD:320555 4/25 (16%)
TM helix 7 826..851 CDD:320555 8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

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