DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl2 and ADGRF1

DIOPT Version :10

Sequence 1:NP_788462.2 Gene:mthl2 / 38636 FlyBaseID:FBgn0035623 Length:518 Species:Drosophila melanogaster
Sequence 2:NP_722582.2 Gene:ADGRF1 / 266977 HGNCID:18990 Length:910 Species:Homo sapiens


Alignment Length:332 Identity:66/332 - (19%)
Similarity:124/332 - (37%) Gaps:103/332 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   223 VMITSLI-CLVLTIAVYLCVKKLMNLEGK--CFICYMMCLFFGYLFLLLDLWEL---SLD----- 276
            :.|.||| ||::....:..:||......:  |.:...:.|      |:.|:|.:   ::|     
Human   595 ISIGSLILCLIIEALFWKQIKKSQTSHTRRICMVNIALSL------LIADVWFIVGATVDTTVNP 653

  Fly   277 --FCKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRSERAFLLYS------------C 327
              .|.||.|..:||.::.|||:.::.              .:.:.|..|::.            |
Human   654 SGVCTAAVFFTHFFYLSLFFWMLMLG--------------ILLAYRIILVFHHMAQHLMMAVGFC 704

  Fly   328 FAWAMPLALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKSWS----AMVYFYGPMVLLILFN-- 386
            ..:..||.::.:|.......|..:      .:..||:   :||    .::.|..|.:.::..|  
Human   705 LGYGCPLIISVITIAVTQPSNTYK------RKDVCWL---NWSNGSKPLLAFVVPALAIVAVNFV 760

  Fly   387 ITMFVLT--------AKHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSFEIF 443
            :.:.|||        .:...|.|.|:.::.::                .|:|..::|::|.|.|.
Human   761 VVLLVLTKLWRPTVGERLSRDDKATIIRVGKS----------------LLILTPLLGLTWGFGIG 809

  Fly   444 SYLVQREKLWVNIFLVADYFNWSQGVIIFVLFILRRKTL--VLFKKQIFPKQRAFSRSATQSTIE 506
            :.:..:...|..||.:.:.|   ||..|....||....|  :||.|              .|.:.
Human   810 TIVDSQNLAWHVIFALLNAF---QGFFILCFGILLDSKLRQLLFNK--------------LSALS 857

  Fly   507 SISQTKR 513
            |..||::
Human   858 SWKQTEK 864

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl2NP_788462.2 Methuselah_N 31..211 CDD:429053
7tmB3_Methuselah-like 215..489 CDD:410632 62/306 (20%)
TM helix 1 215..240 CDD:410632 6/17 (35%)
TM helix 2 249..269 CDD:410632 3/21 (14%)
TM helix 3 279..306 CDD:410632 8/26 (31%)
TM helix 4 322..342 CDD:410632 5/31 (16%)
TM helix 5 367..397 CDD:410632 8/43 (19%)
TM helix 6 419..446 CDD:410632 6/26 (23%)
TM helix 7 454..479 CDD:410632 8/24 (33%)
ADGRF1NP_722582.2 SEA 154..>215 CDD:460188
GPS 532..572 CDD:460350
7tmB2_GPR116-like_Adhesion_VI 582..850 CDD:320598 59/302 (20%)
TM helix 1 584..609 CDD:320598 6/13 (46%)
TM helix 2 624..646 CDD:320598 5/27 (19%)
TM helix 3 658..685 CDD:320598 8/40 (20%)
TM helix 4 699..719 CDD:320598 4/19 (21%)
TM helix 5 740..769 CDD:320598 6/28 (21%)
TM helix 6 786..812 CDD:320598 6/41 (15%)
TM helix 7 817..842 CDD:320598 9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

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