Protein Alignment mthl2 and mthl13

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_788325.2
• Gene: mthl13 / 246395
• FlyBaseID: FBgn0050018
• Length: 440
• Species: Drosophila melanogaster
• Alignment Length: 406
• Identity: 128/406 - (31%)
• Similarity: 194/406 - (47%)
• Gaps: 37/406 - (9%)

  Fly    92 CVRFCCPHDHIMDMGECYANMTTEEN---ELLDPMLNVTLDDGSVVQRHYKKELMV---QWDLPK 150
            |:..|||..::|..|.|    :.:|:   ..||  ||:.|||.|....::..:.::   .||:
  Fly    49 CIPICCPRKNMMANGGC----SFKEHLFRTKLD--LNIRLDDNSTEALYFNNQTLLITSFWDI-- 105

  Fly   151 PCDDMFYLDNRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNSIRIIPHNCLILP 215
              |:|..|..    |||||::||.:..|.||....|.|||............:|.||.|....:.
  Fly   106 --DEMMGLRR----DEYTLYKNGTIYIHSDQSIQTKEEYCFYPHQIYSDFPETIWIISHKFSSIE 164

  Fly   216 SRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFLLLDLWELSLDFCKA 280
            | .|...:...|:||.::...:||.||:|.|..|||.:..:.|||..||..|:|...|..|||..
  Fly   165 S-PGAFELASGSIICYIIIFGIYLFVKELRNDFGKCVMSCVFCLFLDYLIWLMDELRLLDDFCSL 228

  Fly   281 AGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRSERAFLLYSCFAW---AMPLA-LTGVTY 341
            .|::.:||..|...|.||||...||.:|:..:..| |.:  |:.||.||:   |:||. :..:..
  Fly   229 TGYIMFFFDFANSVWFSIISYCIWKKITSVVSQEN-RDQ--FVFYSTFAYGISAIPLGIIISINQ 290

  Fly   342 LADNVVNNEEWQPRVGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVLTAKHIIDSKRTLRK 406
            ..:..:....|.|.|| ...|.:.....|:.||::.|..::...||.|||||.|||:.:||.|..
  Fly   291 FWEEDLRKWNWLPLVG-FSRCSVDDCKRSSWVYYFVPYAIMCAINIIMFVLTIKHIMKTKRNLHN 354

  Fly   407 IARNEGR------IQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLVQREKLWVNIFLVADYFNW 465
            :.:...|      :..||.:.  |..||.:..:||::|...||..:......|....::....::
  Fly   355 LTKRPDRNETCVTVNFLNFEL--YLLFLRISGIMGVAWILIIFLLIEVNSTFWDIFGIIIQQIHY 417

  Fly   466 SQGVIIFVLFILRRKT 481
            ..|:|:|||.|.:|.|
  Fly   418 GFGIILFVLLIFKRST 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	39/124 (31%)
		7tmB3_Methuselah-like	215..489	CDD:410632	89/277 (32%)
		TM helix 1	215..240	CDD:410632	6/24 (25%)
		TM helix 2	249..269	CDD:410632	9/19 (47%)
		TM helix 3	279..306	CDD:410632	10/26 (38%)
		TM helix 4	322..342	CDD:410632	8/23 (35%)
		TM helix 5	367..397	CDD:410632	12/29 (41%)
		TM helix 6	419..446	CDD:410632	8/26 (31%)
		TM helix 7	454..479	CDD:410632	6/24 (25%)
mthl13	NP_788325.2	Mth_Ecto	<49..158	CDD:448329	38/122 (31%)
		7tm_GPCRs	186..440	CDD:475119	84/254 (33%)
		TM helix 2	197..218	CDD:410628	9/20 (45%)
		TM helix 3	227..249	CDD:410628	8/21 (38%)
		TM helix 4	269..285	CDD:410628	7/15 (47%)
		TM helix 5	316..339	CDD:410628	7/22 (32%)
		TM helix 6	376..397	CDD:410628	8/20 (40%)
		TM helix 7	402..431	CDD:410628	7/28 (25%)