DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl2 and ADGRL1

DIOPT Version :10

Sequence 1:NP_788462.2 Gene:mthl2 / 38636 FlyBaseID:FBgn0035623 Length:518 Species:Drosophila melanogaster
Sequence 2:XP_016881964.1 Gene:ADGRL1 / 22859 HGNCID:20973 Length:1506 Species:Homo sapiens


Alignment Length:298 Identity:75/298 - (25%)
Similarity:123/298 - (41%) Gaps:48/298 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   191 LQHRTFGEGNNNSIRIIPHNCLILPSRTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICY 255
            :.||...:|..|.        |:|...|  .|.::.||:||.:.|:.:..::.|...........
Human   853 MAHREIYQGRINE--------LLLSVIT--WVGIVISLVCLAICISTFCFLRGLQTDRNTIHKNL 907

  Fly   256 MMCLFFGYLFLLLDL----WELSLDFCKA-AGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMN 315
            .:.||...|..|:.:    :|::   |.. ||.|.||| :|||.||.:...|.:..|.....|..
Human   908 CINLFLAELLFLVGIDKTQYEIA---CPIFAGLLHYFF-LAAFSWLCLEGVHLYLLLVEVFESEY 968

  Fly   316 IRSERAFLLYSCFAWAMPLALTGVTYLADNVVNNEEWQPRVGDEGHCWIYTKS---WSAMVYFYG 377
            .|::..:|...||    |..:.|:....|        ....|.|..||:...:   ||    |.|
Human   969 SRTKYYYLGGYCF----PALVVGIAAAID--------YRSYGTEKACWLRVDNYFIWS----FIG 1017

  Fly   378 PMVLLILFNITMFVLTAKHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSFEI 442
            |:..:|:.|:...::|...:|.|...|:.   :..|:..:.|........|.|   :|::|:|.:
Human  1018 PVSFVIVVNLVFLMVTLHKMIRSSSVLKP---DSSRLDNIKSWALGAIALLFL---LGLTWAFGL 1076

  Fly   443 FSYLVQREKLWVNIFLVADYFNWSQGVIIFVLFILRRK 480
            .  .:.:|.: |..:|... ||..|||.|||.....:|
Human  1077 L--FINKESV-VMAYLFTT-FNAFQGVFIFVFHCALQK 1110

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl2NP_788462.2 Methuselah_N 31..211 CDD:429053 4/19 (21%)
7tmB3_Methuselah-like 215..489 CDD:410632 69/274 (25%)
TM helix 1 215..240 CDD:410632 7/24 (29%)
TM helix 2 249..269 CDD:410632 4/19 (21%)
TM helix 3 279..306 CDD:410632 12/27 (44%)
TM helix 4 322..342 CDD:410632 5/19 (26%)
TM helix 5 367..397 CDD:410632 8/32 (25%)
TM helix 6 419..446 CDD:410632 6/26 (23%)
TM helix 7 454..479 CDD:410632 10/24 (42%)
ADGRL1XP_016881964.1 Gal_Rha_Lectin_LPHN1 35..131 CDD:438701
OLF 143..399 CDD:470611
PHA03247 <399..503 CDD:223021
HormR 484..547 CDD:214468
GAIN 557..782 CDD:465137
GPS 806..858 CDD:197639 2/4 (50%)
7tmB2_Latrophilin-1 865..1122 CDD:320673 71/286 (25%)
TM helix 1 867..892 CDD:320673 8/26 (31%)
TM helix 2 901..923 CDD:320673 4/21 (19%)
TM helix 3 932..959 CDD:320673 12/27 (44%)
TM helix 4 971..991 CDD:320673 5/23 (22%)
TM helix 5 1008..1037 CDD:320673 8/32 (25%)
TM helix 6 1053..1080 CDD:320673 6/31 (19%)
TM helix 7 1084..1109 CDD:320673 10/26 (38%)
Latrophilin 1121..1506 CDD:460538
Blue background indicates that the domain is not in the aligned region.

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