DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl2 and Adgrl2

DIOPT Version :10

Sequence 1:NP_788462.2 Gene:mthl2 / 38636 FlyBaseID:FBgn0035623 Length:518 Species:Drosophila melanogaster
Sequence 2:NP_599235.3 Gene:Adgrl2 / 171447 RGDID:620835 Length:1487 Species:Rattus norvegicus


Alignment Length:549 Identity:110/549 - (20%)
Similarity:185/549 - (33%) Gaps:172/549 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SSKMLLSASILIYFLLNLQSSSAEIADCSF-------YDTVDISEG---QRLSNG-----SYLYE 53
            :..::|..::|        |:..::.|.:|       :.::.:|..   |...||     ..:|.
  Rat   669 TDNIVLEVAVL--------STEGQVQDFTFHLGFKGAFSSIQLSANTVKQNSRNGLAKVVFIIYR 725

  Fly    54 GL---LIPAHLTAKYEFKLLANGDKEQVPSHVRGCVCK-------LRTCVRFCCPH---DHIMDM 105
            .|   |...:.|.|....||.......|.|||......       |...|.|..||   |:..:.
  Rat   726 SLGPFLSTENATVKLGADLLGRNSTIAVNSHVLSVSINKESSRVYLTDPVLFSMPHIDSDNYFNA 790

  Fly   106 GECYANMTTEENELLDPMLNVTLDDGSVVQRHYKKELMVQW--------DLPK-----PCDDMFY 157
            ...:.|                         :.::.:|..|        |..|     .|.   :
  Rat   791 NCSFWN-------------------------YSERTMMGYWSTQGCKLVDTNKTRTTCACS---H 827

  Fly   158 LDNRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNSIRIIPHNCLILPSRTGQTV 222
            |.|..|           |:.|.:.||.|.                     .|..|:       ||
  Rat   828 LTNFAI-----------LMAHREIVYKDG---------------------VHKLLL-------TV 853

  Fly   223 V----MITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFG-YLFLL-LDLWELSLDFCKAA 281
            :    ::.||:||.:.|..:...:.|.:..........:.||.. ::||: :|..:.::.....|
  Rat   854 ITWVGIVVSLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIGIDKTQYTIACPVFA 918

  Fly   282 GFLGYFFVMAAFFWLSIISRHYWKCLTNPCASMNIRSERAFLLYSCFAWAMPLALTGVTYLADNV 346
            |.| :||.:|||.|:.:.....:..|.....|...|.:    .|....:..|..:.||:...|  
  Rat   919 GLL-HFFFLAAFSWMCLEGVQLYLMLVEVFESEYSRKK----YYYVAGYLFPATVVGVSAAID-- 976

  Fly   347 VNNEEWQPRVGDEGHCWIYTKS---WSAMVYFYGPMVLLILFNITMFVLTAKHIIDSKRTLRKIA 408
                  ....|....||::..:   ||    |.||:..:||.||...|:|...::....||:.  
  Rat   977 ------YKSYGTLEACWLHVDNYFIWS----FIGPVTFIILLNIIFLVITLCKMVKHSNTLKP-- 1029

  Fly   409 RNEGRIQKL----------NSDKQNYTQ------------FLLLFTVMGMSWSFEIFSYLVQREK 451
             :..|::.:          |:|...|..            |.|| .::|::|||.:   |...|:
  Rat  1030 -DSSRLENINNYRVCDGYYNTDLPGYEDNKPFIKSWVLGAFALL-CLLGLTWSFGL---LFVNEE 1089

  Fly   452 LWVNIFLVADYFNWSQGVIIFVLFILRRK 480
            ..|..:|.. .||..||:.||:.....:|
  Rat  1090 TVVMAYLFT-AFNAFQGLFIFIFHCALQK 1117

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl2NP_788462.2 Methuselah_N 31..211 CDD:429053 37/220 (17%)
7tmB3_Methuselah-like 215..489 CDD:410632 68/297 (23%)
TM helix 1 215..240 CDD:410632 7/28 (25%)
TM helix 2 249..269 CDD:410632 4/21 (19%)
TM helix 3 279..306 CDD:410632 9/26 (35%)
TM helix 4 322..342 CDD:410632 4/19 (21%)
TM helix 5 367..397 CDD:410632 11/32 (34%)
TM helix 6 419..446 CDD:410632 9/38 (24%)
TM helix 7 454..479 CDD:410632 8/24 (33%)
Adgrl2NP_599235.3 Gal_Rha_Lectin_LPHN2 36..132 CDD:438702
OLF 142..398 CDD:470611
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 422..462
HormR 469..533 CDD:214468
GAIN 542..764 CDD:465137 20/102 (20%)
GPS 788..840 CDD:197639 11/90 (12%)
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 792..841 11/87 (13%)
7tm_GPCRs 848..1129 CDD:475119 69/302 (23%)
TM helix 1 851..875 CDD:410628 7/30 (23%)
TM helix 2 884..905 CDD:410628 4/20 (20%)
TM helix 3 915..937 CDD:410628 9/22 (41%)
TM helix 4 956..972 CDD:410628 3/15 (20%)
TM helix 5 991..1014 CDD:410628 9/26 (35%)
TM helix 6 1065..1087 CDD:410628 8/25 (32%)
TM helix 7 1091..1116 CDD:410628 8/25 (32%)
Latrophilin 1128..1487 CDD:460538
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1139..1160
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1386..1428
Blue background indicates that the domain is not in the aligned region.

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