DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl2 and Adgrg1

DIOPT Version :10

Sequence 1:NP_788462.2 Gene:mthl2 / 38636 FlyBaseID:FBgn0035623 Length:518 Species:Drosophila melanogaster
Sequence 2:XP_017168066.1 Gene:Adgrg1 / 14766 MGIID:1340051 Length:700 Species:Mus musculus


Alignment Length:324 Identity:76/324 - (23%)
Similarity:120/324 - (37%) Gaps:66/324 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   180 DQVYLDKSEYCL-QHRTFGE---GNNNSIRIIPHNCLILPSRTGQTVVMITSLICLVLTIAVYLC 240
            :.|..|....|| .|.|:..   .::..:.....:.|.|.|..|   .:|::|.| |.|||.|||
Mouse   380 ETVSRDTQTSCLCNHLTYFAVLMVSSTEVEATHKHYLTLLSYVG---CVISALAC-VFTIAAYLC 440

  Fly   241 ---------VKKLMNLEGKCFICYMMCLFFGYLFLLLDLWEL--SLDFCKAAGFLGYFFVMAAFF 294
                     :|..|||....|:       ....|||.:...|  |...|:.:....:|.::|...
Mouse   441 SRRKSRDYTIKVHMNLLSAVFL-------LDVSFLLSEPVALTGSEAACRTSAMFLHFSLLACLS 498

  Fly   295 WLSIISRHYWKCLTNPCASMNIRSERAFLL-YSCFAWAMPLALTGVTYLADNVVNN--------E 350
            |:.:...:.::.:.....:.    ...:|| .|...|..|:.|..:..|.|  |||        .
Mouse   499 WMGLEGYNLYRLVVEVFGTY----VPGYLLKLSIVGWGFPVFLVTLVALVD--VNNYGPIILAVR 557

  Fly   351 EWQPRVGDEGHCWIYTKSWSAMVYFYGPMVLLILFNITMFVLTAKHIIDSKRTLRKIARNEGRIQ 415
            ....||.....||| ..|..:.|...|...|:.|||:.|.......|:                 
Mouse   558 RTPERVTYPSMCWI-RDSLVSYVTNLGLFSLVFLFNLAMLATMVVQIL----------------- 604

  Fly   416 KLNSDKQNYTQFLLLF---TVMGMSWSFEIFSYLVQREKLWV-NIFLVADYFNWSQGVIIFVLF 475
            :|....||:...|.|.   .|:|:.|:...||:.....:|.: .:|.:...|   ||.:||:.:
Mouse   605 RLRPHSQNWPHVLTLLGLSLVLGLPWALVFFSFASGTFQLVILYLFSIITSF---QGFLIFLWY 665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl2NP_788462.2 Methuselah_N 31..211 CDD:429053 6/34 (18%)
7tmB3_Methuselah-like 215..489 CDD:410632 68/285 (24%)
TM helix 1 215..240 CDD:410632 10/24 (42%)
TM helix 2 249..269 CDD:410632 4/19 (21%)
TM helix 3 279..306 CDD:410632 3/26 (12%)
TM helix 4 322..342 CDD:410632 6/20 (30%)
TM helix 5 367..397 CDD:410632 8/29 (28%)
TM helix 6 419..446 CDD:410632 9/29 (31%)
TM helix 7 454..479 CDD:410632 6/23 (26%)
Adgrg1XP_017168066.1 PLL 42..175 CDD:436599
GAIN_A 186..233 CDD:436625
GPS 358..401 CDD:460350 6/20 (30%)
7tm_GPCRs 413..680 CDD:475119 70/291 (24%)
TM helix 1 416..440 CDD:410628 12/27 (44%)
TM helix 2 450..471 CDD:410628 8/27 (30%)
TM helix 3 483..505 CDD:410628 3/21 (14%)
TM helix 4 525..541 CDD:410628 4/15 (27%)
TM helix 5 574..597 CDD:410628 8/22 (36%)
TM helix 6 616..638 CDD:410628 7/21 (33%)
TM helix 7 644..669 CDD:410628 7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

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