DRSC/TRiP Functional Genomics Resources

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Protein Alignment mthl2 and Adgre1

DIOPT Version :10

Sequence 1:NP_788462.2 Gene:mthl2 / 38636 FlyBaseID:FBgn0035623 Length:518 Species:Drosophila melanogaster
Sequence 2:NP_034260.1 Gene:Adgre1 / 13733 MGIID:106912 Length:931 Species:Mus musculus


Alignment Length:569 Identity:119/569 - (20%)
Similarity:208/569 - (36%) Gaps:138/569 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 ASSKMLLSASILIYFLLNLQSSSA------EIADCSFYDTVDISEG--QRLSNGSYL-YEGLLIP 58
            |:|..|:......:|.|:.:.:|.      |..:.:....:.|..|  .::....|| .|..:|.
Mouse   428 ATSVSLVLEQATTWFELSKEETSTLGTILLETVESTMLAALLIPSGNASQMIQTEYLDIESKVIN 492

  Fly    59 AHLTAKYEFKLLANGDKEQVPSHVRGCVCKLRTCVRFCCP--------------HDHIMDMGECY 109
            ..........|.|.|||..|     ||.. ::..|....|              ::...:.|:.:
Mouse   493 EECKENESINLAARGDKMNV-----GCFI-IKESVSTGAPGVAFVSFAHMESVLNERFFEDGQSF 551

  Fly   110 -----------ANMTTEENELLDPMLNVTLDDGSVVQRHYKKE--LMVQWD--------LPKPCD 153
                       ..:|.|:.|.....:..||..   :|...|.|  :.|.|:        .|..|:
Mouse   552 RKLRMNSRVVGGTVTGEKKEDFSKPIIYTLQH---IQPKQKSERPICVSWNTDVEDGRWTPSGCE 613

  Fly   154 DMFYLDNRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNSIRIIPHNCLILPSRT 218
            .:      :..:.:|:....|:...  .:.:...|..::.         |:.||.|         
Mouse   614 IV------EASETHTVCSCNRMANL--AIIMASGELTMEF---------SLYIISH--------- 652

  Fly   219 GQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCFICYMMCLFFGYLFLL--LDLWELSLDFCKAA 281
               |..:.||:||.|.||.:|..:.:.|......:...:|||...:..|  :|..:........|
Mouse   653 ---VGTVISLVCLALAIATFLLCRAVQNHNTYMHLHLCVCLFLAKILFLTGIDKTDNQTACAIIA 714

  Fly   282 GFLGYFFVMAAFFW-------LSIISRHYWKCLTNPCASMNIRSERAFLLYSC-FAWAMPLALTG 338
            |||.|.| :|.|||       |.::.|:.  .:.|..:|.||:     :|:.| |.:.:|:.:  
Mouse   715 GFLHYLF-LACFFWMLVEAVMLFLMVRNL--KVVNYFSSRNIK-----MLHLCAFGYGLPVLV-- 769

  Fly   339 VTYLADNVVNNEEWQPR-VGDEGHCWIYTKS---WSAMVYFYGPMVLLILFNI-----TMFVLTA 394
                   |:.:...||| .|....||:.|::   ||    |.||:.::|..|.     |::||. 
Mouse   770 -------VIISASVQPRGYGMHNRCWLNTETGFIWS----FLGPVCMIITINSVLLAWTLWVLR- 822

  Fly   395 KHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSFEIFSYLVQREKLWVNIFLV 459
                      :|:......:.||...:....:.:....::|.||...||. :.....:...:|.:
Mouse   823 ----------QKLCSVSSEVSKLKDTRLLTFKAIAQIFILGCSWVLGIFQ-IGPLASIMAYLFTI 876

  Fly   460 ADYFNWSQGVIIFVLF-ILRRKTLVLFKKQIFPKQRAFSRSATQSTIES 507
               .|..||..||::. :|.|:....:||.:..|....|.|.|...:.|
Mouse   877 ---INSLQGAFIFLIHCLLNRQVRDEYKKLLTRKTDLSSHSQTSGILLS 922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
mthl2NP_788462.2 Methuselah_N 31..211 CDD:429053 36/217 (17%)
7tmB3_Methuselah-like 215..489 CDD:410632 71/293 (24%)
TM helix 1 215..240 CDD:410632 8/24 (33%)
TM helix 2 249..269 CDD:410632 4/21 (19%)
TM helix 3 279..306 CDD:410632 12/33 (36%)
TM helix 4 322..342 CDD:410632 4/20 (20%)
TM helix 5 367..397 CDD:410632 10/37 (27%)
TM helix 6 419..446 CDD:410632 5/26 (19%)
TM helix 7 454..479 CDD:410632 7/25 (28%)
Adgre1NP_034260.1 EGF_CA 33..63 CDD:238011
EGF_CA 81..115 CDD:214542
EGF_CA 133..172 CDD:214542
EGF_CA 173..>203 CDD:214542
EGF_CA 222..258 CDD:238011
EGF_CA 272..>301 CDD:214542
EGF_CA 319..352 CDD:214542
Cell attachment site. /evidence=ECO:0000255 506..508 0/1 (0%)
GPS 591..640 CDD:197639 7/56 (13%)
GPS. /evidence=ECO:0000255|PROSITE-ProRule:PRU00098 595..642 7/54 (13%)
7tmB2_EMR 644..906 CDD:320555 75/318 (24%)
TM helix 1 646..671 CDD:320555 12/36 (33%)
TM helix 2 680..702 CDD:320555 4/21 (19%)
TM helix 3 711..738 CDD:320555 11/27 (41%)
TM helix 4 755..775 CDD:320555 5/28 (18%)
TM helix 5 792..815 CDD:320555 7/26 (27%)
TM helix 6 839..864 CDD:320555 5/25 (20%)
TM helix 7 868..893 CDD:320555 6/27 (22%)
Blue background indicates that the domain is not in the aligned region.

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