Protein Alignment mthl2 and mthl11

DIOPT Version :10

• Sequence 1: NP_788462.2
• Gene: mthl2 / 38636
• FlyBaseID: FBgn0035623
• Length: 518
• Species: Drosophila melanogaster
• Sequence 2: NP_731479.3
• Gene: mthl11 / 117467
• FlyBaseID: FBgn0045443
• Length: 532
• Species: Drosophila melanogaster
• Alignment Length: 504
• Identity: 184/504 - (36%)
• Similarity: 275/504 - (54%)
• Gaps: 37/504 - (7%)

  Fly    14 LIYFLLNLQSSSAEIADCSFYDTVDISEGQRLSNGSYLYEGLLIPAHLTAKYEFKLLANGDKEQV 78
            |:..:|.:...|.:|.:|.|:|||.:.|.::|.||||.||.::|||.||.||::::..:||:..|
  Fly     9 LLLGILVIGVRSRDIPNCDFFDTVQLRESEKLCNGSYRYEDVVIPAKLTGKYDYEIDYDGDRVSV 73

  Fly    79 PSHVRGCVCKLRTCVRFCCPHDHIMDMGEC----YANMTTEENELLDPMLNVTLDDGSVVQRHYK 139
            |.|:|||||||:||:||||.|..:|....|    |.|:|.|..      |::|..:|||:::|..
  Fly    74 PKHIRGCVCKLKTCIRFCCHHKKLMAGNLCSQDVYENLTYEYT------LDITQLNGSVIKKHVL 132

  Fly   140 KELMVQWDLPKPCDDMFYLD-NRDIMDEYTLFENGRLLRHYDQVYLDKSEYCLQHRTFGEGNNNS 203
            .:::||.|||.||:..:.|| .....|.::|:|||.|.||:||.||.|.|:|||......|.|.|
  Fly   133 NDMVVQQDLPLPCERHYSLDAETSTYDMWSLYENGSLFRHFDQRYLSKQEFCLQPNPTSTGKNYS 197

  Fly   204 IRIIPHNCLILPS----------------RTGQTVVMITSLICLVLTIAVYLCVKKLMNLEGKCF 252
            : |:..||:..||                ......|..:|:..:|:|||.||.:.|..:|.|||.
  Fly   198 L-IVAFNCIQKPSMKMAYGRFECVRKSRLSNASIPVKFSSVFFMVITIAAYLWLPKFRSLHGKCC 261

  Fly   253 ICYMMCLFFGYLFLLLDL---WELSLDFCKAAGFLGYFFVMAAFFWLSIISRHYWKCLTNPCASM 314
            ..|.:||...:|..::.|   :||....|...|:.|||.|||.|.|||:||...|:........:
  Fly   262 NLYFICLAITFLLNVISLFGIFELKTPICYLTGYAGYFTVMATFLWLSVISFDVWRRFAMRKFQV 326

  Fly   315 NIRSER-AFLLYSCFAWAMPLALTGVTYLADNVVN---NEEWQPRVGDEGHCWIYTKSWSAMVYF 375
            ..:::| :|..|:...|:....||.:.:|.|..|.   :..:.|.|| ...|||:|..|||..||
  Fly   327 FYKNKRSSFFNYNIIVWSSAGLLTCIIFLVDQFVETNLDNPYNPAVG-VFSCWIFTNGWSATFYF 390

  Fly   376 YGPMVLLILFNITMFVLTAKHIIDSKRTLRKIARNEGRIQKLNSDKQNYTQFLLLFTVMGMSWSF 440
            |.|:.:||:.|...|.||.::|....:..:|:. |....|||:.:..||..:..||.:||.||..
  Fly   391 YAPLAILIILNCASFFLTTRYIYVENKQNQKVL-NNSEPQKLSRNHANYRIYFRLFIIMGGSWFL 454

  Fly   441 EIFSYLVQREKLWVNIFLVADYFNWSQGVIIFVLFILRRKTLVLFKKQI 489
            ||.:::.:.|.:|..:.::.||.|.|||:||||......:...|.:|:|
  Fly   455 EIIAFICEMENMWKPLIILNDYINCSQGIIIFVATFCNHEMFRLIRKRI 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mthl2	NP_788462.2	Methuselah_N	31..211	CDD:429053	81/184 (44%)
		7tmB3_Methuselah-like	215..489	CDD:410632	96/296 (32%)
		TM helix 1	215..240	CDD:410632	9/40 (23%)
		TM helix 2	249..269	CDD:410632	7/19 (37%)
		TM helix 3	279..306	CDD:410632	14/26 (54%)
		TM helix 4	322..342	CDD:410632	5/19 (26%)
		TM helix 5	367..397	CDD:410632	13/29 (45%)
		TM helix 6	419..446	CDD:410632	10/26 (38%)
		TM helix 7	454..479	CDD:410632	10/24 (42%)
mthl11	NP_731479.3	Methuselah_N	26..204	CDD:429053	81/184 (44%)
		7tmB3_Methuselah-like	236..504	CDD:410632	94/270 (35%)
		TM helix 2	258..280	CDD:410632	7/21 (33%)
		TM helix 3	291..318	CDD:410632	14/26 (54%)
		TM helix 4	335..355	CDD:410632	5/19 (26%)
		TM helix 5	383..412	CDD:410632	13/28 (46%)
		TM helix 6	433..460	CDD:410632	10/26 (38%)
		TM helix 7	468..493	CDD:410632	10/24 (42%)