Protein Alignment TM9SF3 and TM9SF2

DIOPT Version :9

• Sequence 1: NP_647979.1
• Gene: TM9SF3 / 38635
• FlyBaseID: FBgn0035622
• Length: 592
• Species: Drosophila melanogaster
• Sequence 2: NP_004791.1
• Gene: TM9SF2 / 9375
• HGNCID: 11865
• Length: 663
• Species: Homo sapiens
• Alignment Length: 638
• Identity: 204/638 - (31%)
• Similarity: 318/638 - (49%)
• Gaps: 99/638 - (15%)

  Fly    32 DEHNHKYNDREEVVLWMN------TVGPYHNRQETYAYFSLPFCSGQKSSISHYHETLSEALQGV 90
            ||.......:.|:.|::|      :|.||.       |.:..||  |.|......|.|.:.|.|.
Human    48 DEEKKSDECKAEIELFVNRLDSVESVLPYE-------YTAFDFC--QASEGKRPSENLGQVLFGE 103

  Fly    91 ELEFSGYEMEFKSDAPKSVICMVTLQEESA---KAFTYAVKN---EYWYQMYIDGLPI-W---GK 145
            .:|.|.|:..|.......::|..|...|.|   :...:..|:   .|.:...:|.:|: |   .:
Human   104 RIEPSPYKFTFNKKETCKLVCTKTYHTEKAEDKQKLEFLKKSMLLNYQHHWIVDNMPVTWCYDVE 168

  Fly   146 VGER----------------------------DERDGKYYIFTHKKFDIGYN-------GQQIV- 174
            .|:|                            .||| .:|||.|....|.|:       |.::|
Human   169 DGQRFCNPGFPIGCYITDKGHAKDACVISSDFHERD-TFYIFNHVDIKIYYHVVETGSMGARLVA 232

  Fly   175 -----------------------DITLTTEGREELKPGSHINFSYEVNW-KPSKVEFKNRFDKYL 215
                                   ||:....|  |:|    |.::|.|:: :..|:.:.:|:|..|
Human   233 AKLEPKSFKHTHIDKPDCSGPPMDISNKASG--EIK----IAYTYSVSFEEDDKIRWASRWDYIL 291

  Fly   216 DPNFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKDEEIDDMERDLGDEYGWKQV 280
            :.....| |.||||.||.::|:||.|:|:||::|||.||.|||::.:..:|.:    :|:|||.|
Human   292 ESMPHTH-IQWFSIMNSLVIVLFLSGMVAMIMLRTLHKDIARYNQMDSTEDAQ----EEFGWKLV 351

  Fly   281 HGDVFRSPPNTLLFSALVGAGYQLISVVFCVIMFAIVGELY-TERGSMLSTAIFVYAATSPINGY 344
            |||:||.|...:|.|..:|:|.|::.:.|..:.||.:|.|. ..||::::.|:.::.......||
Human   352 HGDIFRPPRKGMLLSVFLGSGTQILIMTFVTLFFACLGFLSPANRGALMTCAVVLWVLLGTPAGY 416

  Fly   345 FGGSLYARLGGRMWIRQMLVSAFTVPVAVCGTAFLINFIAIGYHASRAIPFGTMVAVTCICLFVI 409
            .....|...||..|...:|:::|..|..|....|::|.|..|..:|.||||||:||:..:...:.
Human   417 VAARFYKSFGGEKWKTNVLLTSFLCPGIVFADFFIMNLILWGEGSSAAIPFGTLVAILALWFCIS 481

  Fly   410 LPLTLVGTVVGRNLDGQPDFPCRVNAVPRPIPEKKWYMEPLIIVLLGGVLPFGSIFIEMYFIFTS 474
            :|||.:|...|...:. .:.|.|.|.:||.|||:.:|.:||..:::||:||||.|||:::||..|
Human   482 VPLTFIGAYFGFKKNA-IEHPVRTNQIPRQIPEQSFYTKPLPGIIMGGILPFGCIFIQLFFILNS 545

  Fly   475 FWAYKIYYVYGFMLLVFSILTVVTVCVTIVCTYFLLNAEDYRWQWTSFMAAGSTSIYVYAYSFYY 539
            .|::::||::||:.|||.||.:.....||:..||.|.||||.|||.||:.:|.|::|...|:.:|
Human   546 IWSHQMYYMFGFLFLVFIILVITCSEATILLCYFHLCAEDYHWQWRSFLTSGFTAVYFLIYAVHY 610

  Fly   540 FFFKTKMFGLFQTAFYFGYMALFSGALGIICGTVGYVGTNLFVRKIYSNVKID 592
            ||.|.::.|...|..||||..:......:..||:|:.....||.||||.||:|
Human   611 FFSKLQITGTASTILYFGYTMIMVLIFFLFTGTIGFFACFWFVTKIYSVVKVD 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF3	NP_647979.1	EMP70	60..530	CDD:281048	172/540 (32%)
TM9SF2	NP_004791.1	EMP70	75..619	CDD:367285	180/565 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.830