DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF3 and TM9SF4

DIOPT Version :9

Sequence 1:	NP_647979.1	Gene:	TM9SF3 / 38635	FlyBaseID:	FBgn0035622	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_001285907.1	Gene:	TM9SF4 / 34778	FlyBaseID:	FBgn0028541	Length:	630	Species:	Drosophila melanogaster

Alignment Length:	587	Identity:	205/587 - (34%)
Similarity:	318/587 - (54%)	Gaps:	63/587 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 QETYAYFSLPFCSGQKSSISHYHETLSEALQGVELEFSGYEMEFKSDAPKSVIC-----MVTLQE 117
            |..|.|:||.||..:..::....|.|.|.|:|..:..:.||:.........::|     .:|..:
  Fly    55 QLPYQYYSLRFCYPKNGTLIFKSENLGEVLRGDRIVNTPYEVRMNQQVNCRLLCNQKDRPLTWSK 119

  Fly   118 ESAKAFTYAVKNEYWYQMYIDGLPIWGKV-------------GER-DERDG-KYYIFTHKKFDIG 167
            |.:......:::||:..:.:|.||:..::             |.| .:.|| ..||..|.||.:.
  Fly   120 EDSALVAERIQHEYFVHLLVDNLPVATRIVSVNNPAEVTYEHGYRLGQVDGDNIYINNHLKFILS 184

  Fly   168 YN----------GQQIVDITLTTEGREELK--------PGS------------HINFSYEVNWKP 202
            |:          |.::..::::   .:|||        |.|            .:.|:|.|.||.
  Fly   185 YHMHSKDKYRVVGFEVETVSVS---HKELKFHGDTCNFPDSARPQLVNPNGETQLYFTYSVEWKE 246

  Fly   203 SKVEFKNRFDKYLDPNFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKDEEIDDM 267
            |||.:.:|:|.||.....|  ||||||.||.::|.||.|:::||::||||:|.|||:.|:.|:|.
  Fly   247 SKVSWASRWDIYLGMRDVQ--IHWFSIINSLVVVFFLSGILTMIMIRTLRRDIARYNTDDNIEDT 309

  Fly   268 ERDLGDEYGWKQVHGDVFRSPPNTLLFSALVGAGYQLISVVFCVIMFAIVGELY-TERGSMLSTA 331
            .    :|.|||.|||||||.|.||.||||::|:|.|:..:....|.||::|.|. :.||:::::.
  Fly   310 L----EETGWKLVHGDVFRPPKNTRLFSAIIGSGIQIFFMALITIFFAMLGMLSPSSRGALMTSG 370

  Fly   332 IFVYAATSPINGYFGGSLYARLGGRMWIRQMLVSAFTVPVAVCGTAFLINFIAIGYHASRAIPFG 396
            ||:|.....|.||:...||..:.||.|.|...::|...|..|.||.|.:||......:|.|:||.
  Fly   371 IFMYVFMGTIAGYYAARLYKTMKGREWKRAAFLTATLYPGIVFGTGFFLNFFIWDKSSSGAVPFT 435

  Fly   397 TMVAVTCICLFVILPLTLVGTVVGRNLDGQP-DFPCRVNAVPRPIPEKKWYMEPLIIVLLGGVLP 460
            ||:::..:...:.:||..:|..:|..  .|| ..|.|.|.:||.:|.:.|||..::..|:.|:||
  Fly   436 TMISLLLLWFGISVPLVYLGFYLGYR--KQPYQHPVRTNMIPRQVPTQHWYMNAVLSTLMAGILP 498

  Fly   461 FGSIFIEMYFIFTSFWAYKIYYVYGFMLLVFSILTVVTVCVTIVCTYFLLNAEDYRWQWTSFMAA 525
            ||::|||::|:||:.|..:.||::||:.|||.||.|....::||.|||.|..|||||.|.||:.:
  Fly   499 FGAVFIELFFVFTAIWQNQFYYLFGFLFLVFCILVVSCAQISIVMTYFQLCGEDYRWWWRSFVVS 563

  Fly   526 GSTSIYVYAYSFYYFFFKTKMFGLFQTAFYFGYMALFSGALGIICGTVGYVGTNLFVRKIYSNVK 590
            |.:::||..||.:|||.|.::.....|..|.||..|......::.|::|:....:|:.:||..||
  Fly   564 GGSAVYVLFYSIFYFFTKLEITEFIPTLLYLGYTGLMVLTFWLLTGSIGFFAAYVFILRIYGAVK 628

  Fly   591 ID 592
            ||
  Fly   629 ID 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF3	NP_647979.1	EMP70	60..530	CDD:281048	182/521 (35%)
TM9SF4	NP_001285907.1	EMP70	57..587	CDD:281048	190/540 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461658
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1278
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10766
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.850