DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF3 and Tm9sf3

DIOPT Version :9

Sequence 1:	NP_647979.1	Gene:	TM9SF3 / 38635	FlyBaseID:	FBgn0035622	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	XP_006231475.1	Gene:	Tm9sf3 / 309475	RGDID:	1564625	Length:	587	Species:	Rattus norvegicus

Alignment Length:	579	Identity:	427/579 - (73%)
Similarity:	492/579 - (84%)	Gaps:	4/579 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AICLCLLIASCYVSLSQADEHNHKYNDREEVVLWMNTVGPYHNRQETYAYFSLPFCSGQKSSISH 78
            |..|.||:    :..:::|||.|.|.|:||||||||||||||||||||.|||||||.|.|.||||
  Rat    13 AAALLLLL----LPRARSDEHEHTYQDKEEVVLWMNTVGPYHNRQETYKYFSLPFCVGSKKSISH 73

  Fly    79 YHETLSEALQGVELEFSGYEMEFKSDAPKSVICMVTLQEESAKAFTYAVKNEYWYQMYIDGLPIW 143
            |||||.||||||||||||.:::||.|......|.:.|.:|...||.||:||.||||||||.||||
  Rat    74 YHETLGEALQGVELEFSGLDIKFKDDVMPGTYCEIDLDKEKRDAFVYAIKNHYWYQMYIDDLPIW 138

  Fly   144 GKVGERDERDGKYYIFTHKKFDIGYNGQQIVDITLTTEGREELKPGSHINFSYEVNWKPSKVEFK 208
            |.|||.||....||::|:||.:||:||.:|||:.||:||:.:|.|.:.|..||.|.||.|.|:|:
  Rat   139 GIVGEADENGEDYYLWTYKKLEIGFNGNRIVDVNLTSEGKVKLVPNTKIQMSYSVKWKKSDVKFE 203

  Fly   209 NRFDKYLDPNFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKDEEIDDMERDLGD 273
            :||||||||:||||||||||||||||||||||||||||||||||||||||||:||:|||:|||||
  Rat   204 DRFDKYLDPSFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEEMDDMDRDLGD 268

  Fly   274 EYGWKQVHGDVFRSPPNTLLFSALVGAGYQLISVVFCVIMFAIVGELYTERGSMLSTAIFVYAAT 338
            |||||||||||||...:.|:||:|:|:|.|:.:|...||:.|::.:|||||||||||||||||||
  Rat   269 EYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLYTERGSMLSTAIFVYAAT 333

  Fly   339 SPINGYFGGSLYARLGGRMWIRQMLVSAFTVPVAVCGTAFLINFIAIGYHASRAIPFGTMVAVTC 403
            ||:|||||||||||.|||.||:||.:.||.:|..||||||.||||||.|||||||||||||||.|
  Rat   334 SPVNGYFGGSLYARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIPFGTMVAVCC 398

  Fly   404 ICLFVILPLTLVGTVVGRNLDGQPDFPCRVNAVPRPIPEKKWYMEPLIIVLLGGVLPFGSIFIEM 468
            ||.||||||.||||::||||.|||:|||||||||||||||||:|||.:||.|||:||||||||||
  Rat   399 ICFFVILPLNLVGTILGRNLSGQPNFPCRVNAVPRPIPEKKWFMEPAVIVCLGGILPFGSIFIEM 463

  Fly   469 YFIFTSFWAYKIYYVYGFMLLVFSILTVVTVCVTIVCTYFLLNAEDYRWQWTSFMAAGSTSIYVY 533
            |||||||||||||||||||:||..||.:||||||||||||||||||||||||||::|.||:||||
  Rat   464 YFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFLLNAEDYRWQWTSFLSAASTAIYVY 528

  Fly   534 AYSFYYFFFKTKMFGLFQTAFYFGYMALFSGALGIICGTVGYVGTNLFVRKIYSNVKID 592
            .|||||:||||||:|||||:|||||||:||.||||:||.:||:||:.||||||:|||||
  Rat   529 MYSFYYYFFKTKMYGLFQTSFYFGYMAVFSTALGIMCGAIGYMGTSAFVRKIYTNVKID 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF3	NP_647979.1	EMP70	60..530	CDD:281048	349/469 (74%)
Tm9sf3	XP_006231475.1	EMP70	56..525	CDD:397233	348/468 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350971
Domainoid	1	1.000	775	1.000	Domainoid score	I77
eggNOG	1	0.900	-	-		E1_KOG1278
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10588
Inparanoid	1	1.050	903	1.000	Inparanoid score	I360
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	1	1.000	-	-		FOG0005862
OrthoInspector	1	1.000	-	-		oto96453
orthoMCL	1	0.900	-	-		OOG6_104089
Panther	1	1.100	-	-	LDO	PTHR10766
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X4863
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770