DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TM9SF3 and Tm9sf3

DIOPT Version :9

Sequence 1:	NP_647979.1	Gene:	TM9SF3 / 38635	FlyBaseID:	FBgn0035622	Length:	592	Species:	Drosophila melanogaster
Sequence 2:	NP_579930.1	Gene:	Tm9sf3 / 107358	MGIID:	1914262	Length:	587	Species:	Mus musculus

Alignment Length:	579	Identity:	427/579 - (73%)
Similarity:	492/579 - (84%)	Gaps:	4/579 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AICLCLLIASCYVSLSQADEHNHKYNDREEVVLWMNTVGPYHNRQETYAYFSLPFCSGQKSSISH 78
            |..|.||:    :..:::|||.|.|.|:||||||||||||||||||||.|||||||.|.|.||||
Mouse    13 AAALLLLL----LPRARSDEHEHTYQDKEEVVLWMNTVGPYHNRQETYKYFSLPFCVGSKKSISH 73

  Fly    79 YHETLSEALQGVELEFSGYEMEFKSDAPKSVICMVTLQEESAKAFTYAVKNEYWYQMYIDGLPIW 143
            |||||.||||||||||||.:::||.|......|.:.|.:|...||.||:||.||||||||.||||
Mouse    74 YHETLGEALQGVELEFSGLDIKFKDDVMPGTYCEIDLDKEKRDAFVYAIKNHYWYQMYIDDLPIW 138

  Fly   144 GKVGERDERDGKYYIFTHKKFDIGYNGQQIVDITLTTEGREELKPGSHINFSYEVNWKPSKVEFK 208
            |.|||.||....||::|:||.:||:||.:|||:.||:||:.:|.|.:.|..||.|.||.|.|:|:
Mouse   139 GIVGEADENGEDYYLWTYKKLEIGFNGNRIVDVNLTSEGKVKLVPNTKIQMSYSVKWKKSDVKFE 203

  Fly   209 NRFDKYLDPNFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKDEEIDDMERDLGD 273
            :||||||||:||||||||||||||||||||||||||||||||||||||||||:||:|||:|||||
Mouse   204 DRFDKYLDPSFFQHRIHWFSIFNSFMMVIFLVGLVSMILMRTLRKDYARYSKEEEMDDMDRDLGD 268

  Fly   274 EYGWKQVHGDVFRSPPNTLLFSALVGAGYQLISVVFCVIMFAIVGELYTERGSMLSTAIFVYAAT 338
            |||||||||||||...:.|:||:|:|:|.|:.:|...||:.|::.:|||||||||||||||||||
Mouse   269 EYGWKQVHGDVFRPSSHPLIFSSLIGSGCQIFAVSLIVIIVAMIEDLYTERGSMLSTAIFVYAAT 333

  Fly   339 SPINGYFGGSLYARLGGRMWIRQMLVSAFTVPVAVCGTAFLINFIAIGYHASRAIPFGTMVAVTC 403
            ||:|||||||||||.|||.||:||.:.||.:|..||||||.||||||.|||||||||||||||.|
Mouse   334 SPVNGYFGGSLYARQGGRRWIKQMFIGAFLIPAMVCGTAFFINFIAIYYHASRAIPFGTMVAVCC 398

  Fly   404 ICLFVILPLTLVGTVVGRNLDGQPDFPCRVNAVPRPIPEKKWYMEPLIIVLLGGVLPFGSIFIEM 468
            ||.||||||.||||::||||.|||:|||||||||||||||||:|||.:||.|||:||||||||||
Mouse   399 ICFFVILPLNLVGTILGRNLSGQPNFPCRVNAVPRPIPEKKWFMEPAVIVCLGGILPFGSIFIEM 463

  Fly   469 YFIFTSFWAYKIYYVYGFMLLVFSILTVVTVCVTIVCTYFLLNAEDYRWQWTSFMAAGSTSIYVY 533
            |||||||||||||||||||:||..||.:||||||||||||||||||||||||||::|.||:||||
Mouse   464 YFIFTSFWAYKIYYVYGFMMLVLVILCIVTVCVTIVCTYFLLNAEDYRWQWTSFLSAASTAIYVY 528

  Fly   534 AYSFYYFFFKTKMFGLFQTAFYFGYMALFSGALGIICGTVGYVGTNLFVRKIYSNVKID 592
            .|||||:||||||:|||||:|||||||:||.||||:||.:||:||:.||||||:|||||
Mouse   529 MYSFYYYFFKTKMYGLFQTSFYFGYMAVFSTALGIMCGAIGYMGTSAFVRKIYTNVKID 587

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TM9SF3	NP_647979.1	EMP70	60..530	CDD:281048	349/469 (74%)
Tm9sf3	NP_579930.1	EMP70	56..525	CDD:397233	348/468 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847418
Domainoid	1	1.000	773	1.000	Domainoid score	I79
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10588
Inparanoid	1	1.050	913	1.000	Inparanoid score	I363
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53553
OrthoDB	1	1.010	-	-		D135708at33208
OrthoFinder	1	1.000	-	-		FOG0005862
OrthoInspector	1	1.000	-	-		oto92898
orthoMCL	1	0.900	-	-		OOG6_104089
Panther	1	1.100	-	-	LDO	PTHR10766
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4192
SonicParanoid	1	1.000	-	-		X4863
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940