DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp9 and PHO8

DIOPT Version :9

Sequence 1:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_010769.3	Gene:	PHO8 / 852092	SGDID:	S000002889	Length:	566	Species:	Saccharomyces cerevisiae

Alignment Length:	555	Identity:	143/555 - (25%)
Similarity:	233/555 - (41%)	Gaps:	128/555 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 PVDEERMHPHLPTS--PRLRTISGEETQEFWHSASK-----------KLIREKLEFVRN------ 71
            |.::.|:.|...:|  |:.|.||         ..||           .|:..:|.|..:
Yeast     7 PSEQTRLVPGSDSSSRPKKRRIS---------KRSKIIVSTVVCIGLLLVLVQLAFPSSFALRSA 62

  Fly    72 TKKAKNIILFLGDGMGLATLAAARSY------IGGEELKLSFEEFPFTGLSKTYSVDKIVPDSAC 130
            :.|.||:|.|:.||||.|:|:.|||:      :..::: |:.:|. |.|.|:|.|.|.:|.|||.
Yeast    63 SHKKKNVIFFVTDGMGPASLSMARSFNQHVNDLPIDDI-LTLDEH-FIGSSRTRSSDSLVTDSAA 125

  Fly   131 TSTSYLCGVKANYGTIGVNAHVKRGDCAAMANETNHVFSLGKWAMDAGKAAGLVTTTRVTHASPS 195
            .:|::.|.:|:..|.|||:.|.:  .|..:...          |..||...|||.|||:|.|:|:
Yeast   126 GATAFACALKSYNGAIGVDPHHR--PCGTVLEA----------AKLAGYLTGLVVTTRITDATPA 178

  Fly   196 GVYAHVADREWENNAVLEEACGELSDGLQDIAVQLIHGEVGSKLKVMLGGGKRSFY------SP- 253
            ...:|| |..|:.:.:.....||.              .:|..:.:::|||:..||      ||
Yeast   179 SFSSHV-DYRWQEDLIATHQLGEY--------------PLGRVVDLLMGGGRSHFYPQGEKASPY 228

  Fly   254 EHYDKGRRTDGRNLVEEFEALDAGNTFVKTQKK----LLNVNATETGRLLGLFSKSHMHYHLEQL 314
            .|:  |.|.|||:|::  ||...|..:|..:|.    |.:.....|...||||:.:.:.:.:
Yeast   229 GHH--GARKDGRDLID--EAQSNGWQYVGDRKNFDSLLKSHGENVTLPFLGLFADNDIPFEI--- 286

  Fly   315 ADPDNNE-PTLEEMTQKAIEVLE------TEEQGYFLFVEGGKIDISHHETMARIALDETAELSK 372
             |.|..| |:|:|..:.|:..||      .:..|:||.|||.:||.:.|:......:.|.....:
Yeast   287 -DRDEKEYPSLKEQVKVALGALEKASNEDKDSNGFFLMVEGSRIDHAGHQNDPASQVREVLAFDE 350

  Fly   373 AVKKAREM--TNPEETLIVVTSDHSHTFSVSGYQPRGS--------DIFGAAKANGKDGKPYLA- 426
            |.:...|.  .:..||::|.||||.....|:..|...|        .:...|..:|:..|..|.
Yeast   351 AFQYVLEFAENSDTETVLVSTSDHETGGLVTSRQVTASYPQYVWYPQVLANATHSGEFLKRKLVD 415

  Fly   427 -LSYANGKS--FQDYYNTETHER------VDPTSLPTIGDFDQ-------------LFPAMVPLE 469
             :....|.|  .:::...|..|:      ...:.|.|:...|.             .|.|.:...
Yeast   416 FVHEHKGASSKIENFIKHEILEKDLGIYDYTDSDLETLIHLDDNANAIQDKLNDMVSFRAQIGWT 480

  Fly   470 SETHGGEDVGVFA----SGPWAHLFTGVY--EQNT 498
            :..|...||.::|    ...|:::...:.  .:||
Yeast   481 THGHSAVDVNIYAYANKKATWSYVLNNLQGNHENT 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	141/551 (26%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	129/487 (26%)
PHO8	NP_010769.3	PhoA	8..530	CDD:224699	142/554 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345758
Domainoid	1	1.000	140	1.000	Domainoid score	I1026
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I1177
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm46490
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	11	10.790