DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp9 and alpi.2

DIOPT Version :9

Sequence 1:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001020359.1	Gene:	alpi.2 / 574009	ZFINID:	ZDB-GENE-050626-142	Length:	521	Species:	Danio rerio

Alignment Length:	477	Identity:	208/477 - (43%)
Similarity:	289/477 - (60%)	Gaps:	33/477 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EETQEFWHSASKKLIREKLEFVRNTKKAKNIILFLGDGMGLATLAAARSYIG------GEELKLS 106
            |:...||:..:|..:...|....||.:|||:|||||||||::|:.|||...|      |||..|:
Zfish    29 EKNPNFWYVKAKDSLHASLSMTFNTHRAKNLILFLGDGMGISTVTAARVLKGQMNKKTGEESVLA 93

  Fly   107 FEEFPFTGLSKTYSVDKIVPDSACTSTSYLCGVKANYGTIGVNAHVKRGDCAAMANETNHVFSLG 171
            .:.||:..|||||:||:.:||||.|:|:|||||||||||:|::|..:|..|:::  :.|.|.|:.
Zfish    94 MDTFPYLALSKTYNVDQQMPDSAATATAYLCGVKANYGTLGLSAAAQREVCSSV--KGNEVKSIL 156

  Fly   172 KWAMDAGKAAGLVTTTRVTHASPSGVYAHVADREWENNAVL-EEACGELSDGLQDIAVQLIHGEV 235
            ..|..|||:.|:|:|.||.||||:..|:|..:|.|.::..| .||   ::.|.||||||||   .
Zfish   157 HQAKMAGKSVGIVSTARVQHASPAASYSHTPERGWYSDKELTSEA---VAGGCQDIAVQLI---T 215

  Fly   236 GSKLKVMLGGGKRSFYSPEHYD------KGRRTDGRNLVEEFEALDAGNTFVKTQKKLLNVNATE 294
            .:.:.|:||||::..:..|..|      .|.|.|.||||:|:........:|..:::...||..:
Zfish   216 NTDINVILGGGRQYMFPRETTDPEYSTVTGSRKDKRNLVDEWLKNRKNAQYVWNKQQFDAVNEDK 280

  Fly   295 TGRLLGLFSKSHMHYHLEQLADPDNNEPTLEEMTQKAIEVLETEEQGYFLFVEGGKIDISHHETM 359
            |..|:|||......|.||:  || ..:|:|.||.:|||::|.....|::||||||:||..||...
Zfish   281 TDYLMGLFEPKDTRYELER--DP-KMDPSLTEMVEKAIKILRKNPNGFYLFVEGGRIDHGHHAGQ 342

  Fly   360 ARIALDETAELSKAVKKAREMTNPEETLIVVTSDHSHTFSVSGYQPRGSDIFGAAKANGKDGKPY 424
            |:.||.|..|...::::|.::|:..:||.|||:||||.||..||..||:.:.|.:.|.|:|||.:
Zfish   343 AKYALTEAVEFDNSIERAGQLTSELDTLSVVTADHSHVFSFGGYSYRGNPVLGVSYAKGEDGKSF 407

  Fly   425 LALSYANGKSFQDYYNT--ETHERVDPTSLPTIGDFDQLFPAMVPLESETHGGEDVGVFASGPWA 487
            ....|.||..:|....|  :.:|.|.       |..|.|..|.|||:|||||.|||.:||.||.|
Zfish   408 TNALYGNGPGYQITNGTRPDVNESVS-------GRDDYLQQAAVPLDSETHGSEDVAIFAKGPMA 465

  Fly   488 HLFTGVYEQNTIPHMMAFAACV 509
            |||.||.||:.|||.||||||:
Zfish   466 HLFHGVQEQSYIPHAMAFAACI 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	197/462 (43%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	199/447 (45%)
alpi.2	NP_001020359.1	Alk_phosphatase	56..487	CDD:278666	200/448 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593254
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134333
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910