DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp9 and alpi.1

DIOPT Version :9

Sequence 1:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001014375.1	Gene:	alpi.1 / 541539	ZFINID:	ZDB-GENE-050327-78	Length:	532	Species:	Danio rerio

Alignment Length:	517	Identity:	205/517 - (39%)
Similarity:	287/517 - (55%)	Gaps:	96/517 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EETQEFWHSASKKLIREKLEFVRNTKKAKNIILFLGDGMGLATLAAARSYIG------GEELKLS 106
            |:...:|:..:::.::..|.......:|||||||:|||||::|::|||...|      |||..|:
Zfish    34 EKDPAYWNDQARRTLQTALTLPLRVNRAKNIILFVGDGMGVSTVSAARILRGQMEGQSGEETILA 98

  Fly   107 FEEFPFTGLSKTYSVDKIVPDSACTSTSYLCGVKANYGTIGVNAHVKRGDCAAMANET--NHVFS 169
            .:.||:..|||||.|||.|.|||.|:|:|.||||||..|:|::|.....:|    |.|  |.|||
Zfish    99 MDTFPYLALSKTYCVDKQVADSASTATAYHCGVKANAKTVGLSAKAVAYEC----NTTFGNEVFS 159

  Fly   170 LGKWAMDAGKAAGLVTTTRVTHASPSGVYAHVADREWENNA-VLEEACGELSDGLQDIAVQLIHG 233
            :...|...||:.|:||||||.||||:..|||...|:|.::| |..||   ...|.:|||.||:
Zfish   160 VLHRAKAQGKSVGIVTTTRVQHASPAAAYAHSVSRKWYSDADVPSEA---RRQGCKDIATQLV-- 219

  Fly   234 EVGSKLKVMLGGGKRSFYSPE-----HYD----KGRRTDGRNLV------------------EEF 271
             ..:.:.|:|||| |.:.:|:     .|.    ||.|.|.:||:                  |:|
Zfish   220 -TNTDIDVILGGG-RMYMTPKGTPDPEYSSSSHKGDRKDKKNLINVWLNARKGRNAQYVWNKEQF 282

  Fly   272 EALDAGNTFVKTQKKLLNVNATETGRLLGLFSKSHMHYHLEQLADPDNNEPTLEEMTQKAIEVLE 336
            .|:|     |||           |..|:|||....|.:.:.:....|   |::.:||:|||::|.
Zfish   283 NAVD-----VKT-----------TDCLMGLFEPKDMRFEVFRNRTRD---PSIVDMTEKAIQILS 328

  Fly   337 TEEQGYFLFVEGGKIDISHHETMARIALDETAELSKAVKKAREMTNPEETLIVVTSDHSHTFSVS 401
            ...:|:|||||||:||..||:.:|::||.||....:|:::|.|:|:..:||.|||:||||.|:..
Zfish   329 KNPKGFFLFVEGGRIDHGHHDGVAKLALTETIMFDRAIQRASELTSESDTLTVVTADHSHVFTFG 393

  Fly   402 GYQPRGSDIFGAAKANGKDGKPYLALSYANGKSFQ------------DYYNTETHERVDPTSLPT 454
            |..|||:.|||.|....:|..||.::.||||..:.            |||:.|..::
Zfish   394 GKTPRGNPIFGLAPKQAEDDLPYTSILYANGPGYDHVNGTRGNVSVLDYYDEEYKQQ-------- 450

  Fly   455 IGDFDQLFPAMVPLESETHGGEDVGVFASGPWAHLFTGVYEQNTIPHMMAFAACVGDGLTAC 516
                     |.|||||||||||||.::|.||.||||.||.|||.:.|.||:|||: :..|.|
Zfish   451 ---------AAVPLESETHGGEDVAIYAKGPMAHLFHGVKEQNYVAHAMAYAACL-EPYTNC 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	194/495 (39%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	198/480 (41%)
alpi.1	NP_001014375.1	PhoA	46..493	CDD:224699	198/493 (40%)
alpi.1	NP_001014375.1	Alk_phosphatase	61..496	CDD:278666	199/481 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593241
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8508
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.940