DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp9 and Alp4

DIOPT Version :9

Sequence 1:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_524601.2	Gene:	Alp4 / 43671	FlyBaseID:	FBgn0016123	Length:	596	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	210/564 - (37%)
Similarity:	297/564 - (52%)	Gaps:	96/564 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LGLLTVVWGAAVPGRAPVDEERMHPHLPTSPRLRTISG---------------EETQEFWHSASK 59
            ||.|.....|.|..:.|             |.:||:|.               .|..||||:...
  Fly    11 LGSLVAFSWAGVTTQPP-------------PLIRTLSAGGDIGPQFDVGKTKEPEDAEFWHNVGL 62

  Fly    60 KLIREKLEFVRNT------KKAKNIILFLGDGMGLATLAAARSYIG-------GEELKLSFEEFP 111
            :.:.:.::..:..      |||:|||:|:|||||::|::|.|.|.|       |||..|.|::||
  Fly    63 RQLEKTIKQAQRVKEDSYQKKARNIIIFIGDGMGISTISAGRIYKGQYLKHGYGEEETLVFDDFP 127

  Fly   112 FTGLSKTYSVDKIVPDSACTSTSYLCGVKANYGTIGVNA--HVKRGDCAAMANETNHVFSLGKWA 174
            .||::|||:|||.|||||.|:|:...|.|.:||.||::|  ..|.|       :...|.|:.:||
  Fly   128 NTGMAKTYNVDKQVPDSAGTATAIFSGSKTHYGAIGMDATRSKKNG-------QQGRVQSVMEWA 185

  Fly   175 MDAGKAAGLVTTTRVTHASPSGVYAHVADREWE-NNAVLEEACGELSDGLQDIAVQLIHGEVGSK 238
            ...||..|:|||||:|||:|:..|||:.||:|| :..|..|:.|    ...|||.||:....|::
  Fly   186 QKEGKRTGVVTTTRITHATPAATYAHIYDRDWECDTEVPAESVG----FHVDIARQLVENAPGNR 246

  Fly   239 LKVMLGGG------------KRSFYSPEHYDKGRRTDGRNLVEEFEALDAGNT----FVKTQKKL 287
            ..|:||||            |.:.:.........|.|.|||..|:.|..|.:|    .|..:|.|
  Fly   247 FNVILGGGMSPMGILNASEVKTTIFEGPTETICTRGDNRNLPAEWLAHHANDTVPPALVHNRKDL 311

  Fly   288 LNVNATETGRLLGLFSKSHMHYHLEQLADPDNNEPTLEEMTQKAIEVLE--TEEQGYFLFVEGGK 350
            ||||..:...|:|||..:|:.|.:.:.|    .||:|:|||:.|:.:||  .|..|:.|.||||:
  Fly   312 LNVNVKKVDHLMGLFRNNHITYSIAREA----GEPSLQEMTETALGILERGDESNGFVLLVEGGR 372

  Fly   351 IDISHHETMARIALDETAELSKAVKKAREMTNPEETLIVVTSDHSHTFSVSGYQPRGSDIFGAAK 415
            ||..||...||.||.|..|...|::.|...|:|:||||:||:||||..:.:||..||:||.|.|.
  Fly   373 IDQGHHMNYARAALHELYEFDLAIQAAVNNTDPDETLILVTADHSHAVTFNGYALRGADILGTAN 437

  Fly   416 ANGK-DGKPYLALSYANGKSFQDYYNTET-------------HERVDPTSLPTIGDFDQLFPAMV 466
            ::.| |...|..:|||||..:.|:...::             |...:..:.||....     |.|
  Fly   438 SHEKNDPMFYETISYANGPGYWDHLANDSRPQNSSNMWMPLKHFTAEERAAPTYRHL-----ATV 497

  Fly   467 PLESETHGGEDVGVFASGPWAHLFTGVYEQNTIPHMMAFAACVG 510
            |.:.||||||||.|||.||.:.|..||:|||.:.::|::|.|:|
  Fly   498 PRKDETHGGEDVAVFAYGPGSSLIRGVFEQNYLAYVMSYAGCLG 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	201/546 (37%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	191/474 (40%)
Alp4	NP_524601.2	PhoA	60..534	CDD:224699	191/493 (39%)
Alp4	NP_524601.2	alkPPc	85..541	CDD:214515	191/475 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466685
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	11	10.800