DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp9 and Alp1

DIOPT Version :9

Sequence 1:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001262159.1	Gene:	Alp1 / 40372	FlyBaseID:	FBgn0283479	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	500	Identity:	235/500 - (47%)
Similarity:	323/500 - (64%)	Gaps:	33/500 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LRTISGEETQEFWHSASKKLIREKLEFVRNTKKAKNIILFLGDGMGLATLAAARSYIG------G 100
            |.:||..:::|||...:::.:..||....|..:|||:|.||||||.:.|:.|.|.:.|      |
  Fly    31 LDSISELKSKEFWFHDAQRTLYNKLSTPPNQYRAKNVIFFLGDGMSVPTVTAGRIFDGQLRGVVG 95

  Fly   101 EELKLSFEEFPFTGLSKTYSVDKIVPDSACTSTSYLCGVKANYGTIGVNAHVKRGDCAAMANETN 165
            |..:|.||:|.:.||||||.|:|.|.|||||:::||.|:||||.||||.|.|:..||.......|
  Fly    96 ERNRLEFEKFNYVGLSKTYCVNKQVADSACTASAYLSGIKANYLTIGVTADVELNDCRGSRLPQN 160

  Fly   166 HVFSLGKWAMDAGKAAGLVTTTRVTHASPSGVYAHVADREWENNAVLEEACGELSDGLQDIAVQL 230
            .:.|:..||:...|:||||||||||||||:|||||.::|::|::..:.: .|:......|||.||
  Fly   161 RLSSIAAWALKGSKSAGLVTTTRVTHASPAGVYAHTSNRDFESDYDVTK-LGQNPGNCPDIAQQL 224

  Fly   231 IHGEVGSKLKVMLGGGKRSFYSPEHYD----KGRRTDGRNLVEEFEALDAGNT-FVKTQKKLLNV 290
            |.|:||.:|:|::|||...|......|    ||:|.|.|||:||::....||. .|.::..|||.
  Fly   225 IDGDVGKRLRVVMGGGTIKFLPNTTNDVFGNKGQRLDNRNLIEEWQQTKPGNARVVFSRTDLLNN 289

  Fly   291 NATETGRLLGLFSKSHMHYHLEQLADPDNNEPTLEEMTQKAIEVLETEEQGYFLFVEGGKIDISH 355
            :|..|..|||||:.||:.||::...|    .|||.|||..||.||..:..|||||||||:||.:|
  Fly   290 DAQNTDFLLGLFNASHLAYHMDDSID----TPTLPEMTAAAINVLSRDPNGYFLFVEGGRIDHAH 350

  Fly   356 HETMARIALDETAELSKAVKKAREMTNPEETLIVVTSDHSHTFSVSGYQPRGSDIFGA-AKANGK 419
            |||.|:.|||||.:.|.||:|||::|||.:|||||::||.||.::|||....:.|.|. ::.:..
  Fly   351 HETKAKKALDETVQFSDAVRKARQLTNPWDTLIVVSADHGHTVTISGYPDVNNSIVGLNSELSNV 415

  Fly   420 DGKPYLALSYANGKSFQDYYNTE--THERVDPTSLPTIGDF---DQLFPAMVPLESETHGGEDVG 479
            |..||.::|||||.:::.:|.:.  ..||||..:|    ||   |.::|..||:..|||||.||.
  Fly   416 DQLPYTSISYANGPAYERFYKSTDGVVERVDLRNL----DFSKPDAIYPHGVPMTEETHGGGDVA 476

  Fly   480 VFA-------SGPWAHLFTGVYEQNTIPHMMAFAACVGDGLTACD 517
            |:|       .|||:|||||||||:|:||:|.||:|:|.|:|.||
  Fly   477 VYAHVVEYLLQGPWSHLFTGVYEQSTLPHLMGFASCLGPGITYCD 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	221/477 (46%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	220/456 (48%)
Alp1	NP_001262159.1	alkPPc	65..514	CDD:214515	220/457 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466632
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	11	10.800