DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp9 and Alpl

DIOPT Version :9

Sequence 1:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_037191.2	Gene:	Alpl / 25586	RGDID:	2100	Length:	524	Species:	Rattus norvegicus

Alignment Length:	494	Identity:	214/494 - (43%)
Similarity:	295/494 - (59%)	Gaps:	44/494 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EETQEFWHSASKKLIREKLEFVR-NTKKAKNIILFLGDGMGLATLAAARSYIG------GEELKL 105
            |:...:|...:::.::..|:..: ||..|||||:|||||||::|:.|||...|      |||.:|
  Rat    23 EKDPSYWRQQAQETLKNALKLQKLNTNVAKNIIMFLGDGMGVSTVTAARILKGQLHHNTGEETRL 87

  Fly   106 SFEEFPFTGLSKTYSVDKIVPDSACTSTSYLCGVKANYGTIGVNAHVKRGDCAAMANET--NHVF 168
            ..::|||..|||||:.:..|||||.|:|:||||||||.||:||:|..:|..|    |.|  |.|.
  Rat    88 EMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRC----NTTQGNEVT 148

  Fly   169 SLGKWAMDAGKAAGLVTTTRVTHASPSGVYAHVADREW-ENNAVLEEACGELSDGLQDIAVQLIH 232
            |:.:||.||||:.|:||||||.||:||..|||.|||:| .:|.:..||   ||.|.:|||.||:|
  Rat   149 SILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEA---LSQGCKDIAYQLMH 210

  Fly   233 GEVGSKLKVMLGGGKRSFYSPEHYD---------KGRRTDGRNLV---EEFEALDAGNTFVKTQK 285
            ..  ..:.|::|||::..|.....|         :|.|.||.:|:   :.|:.....:.:|..:.
  Rat   211 NI--KDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRHKHSHYVWNRT 273

  Fly   286 KLLNVNATETGRLLGLFSKSHMHYHLEQLADPDNN--EPTLEEMTQKAIEVLETEEQGYFLFVEG 348
            :||.::.:....|||||....|.|.|.:     ||  :|:|.||.:.|:.:|....:|:||.|||
  Rat   274 ELLALDPSRVDYLLGLFEPGDMQYELNR-----NNLTDPSLSEMVEVALRILTKNPKGFFLLVEG 333

  Fly   349 GKIDISHHETMARIALDETAELSKAVKKAREMTNPEETLIVVTSDHSHTFSVSGYQPRGSDIFG- 412
            |:||..|||..|:.||.|..|:.:|:.||..||:.::||.|||:||||.|:..||.|||:.|||
  Rat   334 GRIDHGHHEGKAKQALHEAVEMDEAIGKAGTMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFGL 398

  Fly   413 AAKANGKDGKPYLALSYANGKSFQDYYNTETHERVDPTSLPTIGDFDQLFPAMVPLESETHGGED 477
            |...:..|.||:.|:.|.||..    |.....|| :..|:......:....:.|||..|||||||
  Rat   399 APMVSDTDKKPFTAILYGNGPG----YKVVDGER-ENVSMVDYAHNNYQAQSAVPLRHETHGGED 458

  Fly   478 VGVFASGPWAHLFTGVYEQNTIPHMMAFAACVGDGLTAC 516
            |.|||.||.|||..||:|||.|||:||:|:|:|..|..|
  Rat   459 VAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIGANLDHC 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	201/472 (43%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	205/456 (45%)
Alpl	NP_037191.2	Alk_phosphatase	51..490	CDD:395188	205/457 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351468
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1947
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810