DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp9 and ALPP

DIOPT Version :9

Sequence 1:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_001623.3	Gene:	ALPP / 250	HGNCID:	439	Length:	535	Species:	Homo sapiens

Alignment Length:	542	Identity:	218/542 - (40%)
Similarity:	298/542 - (54%)	Gaps:	81/542 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLSLKFWIRLGLLTVVWGAAVPGRAPVDEERMHPHLPTSPRLRTISGEETQEFWHSASKKLIREK 65
            :|.|:..:.||::            ||:                   ||..:||:       ||.
Human    12 LLGLRLQLSLGII------------PVE-------------------EENPDFWN-------REA 38

  Fly    66 LEFVRNTKK-------AKNIILFLGDGMGLATLAAARSYIG------GEELKLSFEEFPFTGLSK 117
            .|.:...||       |||:|:|||||||::|:.|||...|      |.|:.|:.:.||:..|||
Human    39 AEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAARILKGQKKDKLGPEIPLAMDRFPYVALSK 103

  Fly   118 TYSVDKIVPDSACTSTSYLCGVKANYGTIGVNAHVKRGDCAAMANET--NHVFSLGKWAMDAGKA 180
            ||:|||.||||..|:|:||||||.|:.|||::|..:...|    |.|  |.|.|:...|..|||:
Human   104 TYNVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARFNQC----NTTRGNEVISVMNRAKKAGKS 164

  Fly   181 AGLVTTTRVTHASPSGVYAHVADREWENNAVLEEACGELSDGLQDIAVQLIHGEVGSKLKVMLGG 245
            .|:||||||.||||:|.|||..:|.|.::|.:..:..:  :|.||||.|||.   ...:.|:|||
Human   165 VGVVTTTRVQHASPAGTYAHTVNRNWYSDADVPASARQ--EGCQDIATQLIS---NMDIDVILGG 224

  Fly   246 GKRSFY-----SPEHYDK----GRRTDGRNLVEEFEALDAGNTFVKTQKKLLNVNA-TETGRLLG 300
            |::..:     .||:.|.    |.|.||:|||:|:.|...|..:|..:.:|:..:. .....|:|
Human   225 GRKYMFRMGTPDPEYPDDYSQGGTRLDGKNLVQEWLAKRQGARYVWNRTELMQASLDPSVTHLMG 289

  Fly   301 LFSKSHMHYHLEQLADPDNNEPTLEEMTQKAIEVLETEEQGYFLFVEGGKIDISHHETMARIALD 365
            ||....|.|.:.:.:..|   |:|.|||:.|:.:|....:|:|||||||:||..|||:.|..||.
Human   290 LFEPGDMKYEIHRDSTLD---PSLMEMTEAALRLLSRNPRGFFLFVEGGRIDHGHHESRAYRALT 351

  Fly   366 ETAELSKAVKKAREMTNPEETLIVVTSDHSHTFSVSGYQPRGSDIFGAAKANGKDGKPYLALSYA 430
            ||.....|:::|.::|:.|:||.:||:||||.||..||..|||.|||.|....:|.|.|..|.|.
Human   352 ETIMFDDAIERAGQLTSEEDTLSLVTADHSHVFSFGGYPLRGSSIFGLAPGKARDRKAYTVLLYG 416

  Fly   431 NGKSFQDYYNTETHERVDPTSLPTIGDFDQLFPAMVPLESETHGGEDVGVFASGPWAHLFTGVYE 495
            ||..    |..:...|.|.|...: |..:....:.|||:.|||.||||.|||.||.|||..||.|
Human   417 NGPG----YVLKDGARPDVTESES-GSPEYRQQSAVPLDEETHAGEDVAVFARGPQAHLVHGVQE 476

  Fly   496 QNTIPHMMAFAACVGDGLTACD 517
            |..|.|:||||||: :..||||
Human   477 QTFIAHVMAFAACL-EPYTACD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	200/508 (39%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	197/450 (44%)
ALPP	NP_001623.3	PRK10518	28..478	CDD:236706	199/473 (42%)
		Alk_phosphatase	55..490	CDD:278666	198/451 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	425..449		5/24 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157498
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.810