DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp9 and Akp3

DIOPT Version :9

Sequence 1:	NP_001286944.1	Gene:	Alp9 / 38633	FlyBaseID:	FBgn0035620	Length:	517	Species:	Drosophila melanogaster
Sequence 2:	NP_031458.2	Gene:	Akp3 / 11648	MGIID:	87984	Length:	559	Species:	Mus musculus

Alignment Length:	490	Identity:	207/490 - (42%)
Similarity:	292/490 - (59%)	Gaps:	43/490 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 EETQEFWHSASKKLI--REKLEFVRNTKKAKNIILFLGDGMGLATLAAARSYIG------GEELK 104
            ||...||:..:.:.:  .:||:.::.:  |||:|:|||||||:.|:.|.|...|      |.|..
Mouse    25 EENPAFWNKKAAEALDAAKKLQPIQTS--AKNLIIFLGDGMGVPTVTATRILKGQLEGHLGPETP 87

  Fly   105 LSFEEFPFTGLSKTYSVDKIVPDSACTSTSYLCGVKANYGTIGVNAHVKRGDCAAMANET--NHV 167
            |:.:.||:..||||||||:.|||||.|:|:||||||.||.||||:|..:...|    |.|  |.|
Mouse    88 LAMDRFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARFDQC----NTTFGNEV 148

  Fly   168 FSLGKWAMDAGKAAGLVTTTRVTHASPSGVYAHVADREWENNAVLEEACGELSDGLQDIAVQLIH 232
            ||:...|..|||:.|:||||||.||||||.|.|..:|.|..:|  :.....|.:|.:|||.|||.
Mouse   149 FSVMYRAKKAGKSVGVVTTTRVQHASPSGTYVHTVNRNWYGDA--DMPASALREGCKDIATQLIS 211

  Fly   233 GEVGSKLKVMLGGGKRSFY-----SPEH----YDKGRRTDGRNLVEEFEALDAGNTFVKTQKKLL 288
               ...:.|:||||::..:     .||:    .:.|.|.||||||:|:.:...|:.:|..:::|:
Mouse   212 ---NMDINVILGGGRKYMFPAGTPDPEYPNDANETGTRLDGRNLVQEWLSKHQGSQYVWNREQLI 273

  Fly   289 -NVNATETGRLLGLFSKSHMHYHLEQLADPDNNEPTLEEMTQKAIEVLETEEQGYFLFVEGGKID 352
             .........|:|||......:.:::  || ..:|:|::||:.|::||....:|::||||||:||
Mouse   274 QKAQDPSVTYLMGLFEPVDTKFDIQR--DP-LMDPSLKDMTEAAVKVLSRNPKGFYLFVEGGRID 335

  Fly   353 ISHHETMARIALDETAELSKAVKKAREMTNPEETLIVVTSDHSHTFSVSGYQPRGSDIFGAAKAN 417
            ..||...|.:||.|......|:::|.::|:..:||.:||:||||.||..||..||:.|||.|..|
Mouse   336 RGHHLGTAYLALTEAVMFDLAIERASQLTSERDTLTIVTADHSHVFSFGGYTLRGTSIFGLAPLN 400

  Fly   418 GKDGKPYLALSYANGKSFQDYYNTETHERVDPTSLPTIG-DFDQLFPAMVPLESETHGGEDVGVF 481
            ..|||||.::.|.||..:     ..|.||.:.|:..:.| .:.|  .|.||::|||||||||.:|
Mouse   401 ALDGKPYTSILYGNGPGY-----VGTGERPNVTAAESSGSSYRQ--QAAVPVKSETHGGEDVAIF 458

  Fly   482 ASGPWAHLFTGVYEQNTIPHMMAFAACVGDGLTAC 516
            |.||.|||..||.|||.|.|:||||.|: :..|.|
Mouse   459 ARGPQAHLLHGVQEQNYIAHVMAFAGCL-EPYTDC 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp9	NP_001286944.1	PRK10518	12..496	CDD:236706	195/468 (42%)
Alp9	NP_001286944.1	ALP_like	75..508	CDD:304875	198/451 (44%)
Akp3	NP_031458.2	Alk_phosphatase	52..486	CDD:278666	198/452 (44%)
Akp3	NP_031458.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	496..531
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847878
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134333
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	1	0.950	-	0	Normalized mean entropy	S3647
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8682
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R8508
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790