DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp10 and PHO8

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_010769.3	Gene:	PHO8 / 852092	SGDID:	S000002889	Length:	566	Species:	Saccharomyces cerevisiae

Alignment Length:	516	Identity:	143/516 - (27%)
Similarity:	219/516 - (42%)	Gaps:	123/516 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGDSNKQVFFEKFP----------Y 112
            |..|.:.|.|||      ||||.|:.|||...:::..|:|    |:.|  ...|          :
Yeast    55 SSFALRSASHKK------KNVIFFVTDGMGPASLSMARSF----NQHV--NDLPIDDILTLDEHF 107

  Fly   113 LGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSSHVQSIGQWAQEAGK 177
            :|.|:|.:.:....|||..|||:...:|:..|.|||:.  ....|.|        :.:.|:.||.
Yeast   108 IGSSRTRSSDSLVTDSAAGATAFACALKSYNGAIGVDP--HHRPCGT--------VLEAAKLAGY 162

  Fly   178 WAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSKCSPDVNTDIARQLVEWPVGQELRVIMGG 242
            ..|||.|.|:|.|:||...:||..| |:.|  :|::           .||.|:|:|:.:.::|||
Yeast   163 LTGLVVTTRITDATPASFSSHVDYR-WQED--LIAT-----------HQLGEYPLGRVVDLLMGG 213

  Fly   243 GRSYFRDQSQH-DETGVSGLRTDGRDLISDWREIKKQQGAEGKYVWSLKG----LKETDISKTDY 302
            |||:|..|.:. ...|..|.|.||||||.:      .|....:||...|.    ||....:.|..
Yeast   214 GRSHFYPQGEKASPYGHHGARKDGRDLIDE------AQSNGWQYVGDRKNFDSLLKSHGENVTLP 272

  Fly   303 LLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSK--NEE----GYFLFVESGRIDMAH 361
            .||||..:.:|:..||....|    |||.:..:.|:..|.|  ||:    |:||.||..|||.|.
Yeast   273 FLGLFADNDIPFEIDRDEKEY----PSLKEQVKVALGALEKASNEDKDSNGFFLMVEGSRIDHAG 333

  Fly   362 H----ATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSH---------TMSINGYPYRR 413
            |    |::..:.|...|.|...:|.|.  ..:.:|::|.||||..         |.|...|.:..
Yeast   334 HQNDPASQVREVLAFDEAFQYVLEFAE--NSDTETVLVSTSDHETGGLVTSRQVTASYPQYVWYP 396

  Fly   414 QNILSL--------------------APNLADDELPFTILSYANGPGFDDTYSTKDGRID-LSHA 457
            |.:.:.                    |.:..::.:...||....|     .|...|..:: |.|.
Yeast   397 QVLANATHSGEFLKRKLVDFVHEHKGASSKIENFIKHEILEKDLG-----IYDYTDSDLETLIHL 456

  Fly   458 DTTSAEFE--------FQATVPLSSETHGAEDVGVFA----SGPFEHLFT---GNYEQSAI 503
            |..:...:        |:|.:..::..|.|.||.::|    ...:.::..   ||:|.:.:
Yeast   457 DDNANAIQDKLNDMVSFRAQIGWTTHGHSAVDVNIYAYANKKATWSYVLNNLQGNHENTEV 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	143/516 (28%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	137/499 (27%)
PHO8	NP_010769.3	PhoA	8..530	CDD:224699	143/516 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345749
Domainoid	1	1.000	140	1.000	Domainoid score	I1026
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I1177
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm46490
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	11	10.790