DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp10 and Akp3

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_073171.2	Gene:	Akp3 / 64621	RGDID:	621650	Length:	558	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	212/499 - (42%)
Similarity:	288/499 - (57%)	Gaps:	37/499 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLQSSRDFEALDEELDTRFWHDKAQSILADKLAGHKKLN--ENRAKNVILFLGDGMSVHTIAATR 95
            |||.|.....::|| :..||:.||    ||.|...|||.  :..|||:|:||||||.|.|:.|||
  Rat    13 RLQLSLSVIPVEEE-NPAFWNQKA----ADALNVAKKLQPIQTSAKNLIIFLGDGMGVPTVTATR 72

  Fly    96 AFMGD------SNKQVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQR 154
            ...|.      ....:..:.|||:.|||||:|:.:.||||:||||||.|||.||.||||:|..:.
  Rat    73 ILKGQLEGNLGPETPLAMDHFPYMALSKTYSVDRQVPDSASTATAYLCGVKTNYKTIGVSAAARF 137

  Fly   155 GDCVTNSSSHVQSIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSKCSPDV 219
            ..|.|...:.|.|:...|::|||..|:|||.||.||||||.|.|...|||..|.::.:|......
  Rat   138 DQCNTTFGNEVLSVMYRAKKAGKSVGVVTTTRVQHASPAGTYVHTVNRNWYGDADMPASALQEGC 202

  Fly   220 NTDIARQLVEWPVGQELRVIMGGGRSYF-----RDQSQHDETGVSGLRTDGRDLISDWREIKKQQ 279
            . |||.|||.   ..::.||:||||.|.     .|....::...:|.|.||::|:.:|  :.|.|
  Rat   203 K-DIATQLVS---NMDINVILGGGRKYMFPAGTPDPEYPNDVNETGTRLDGKNLVQEW--LSKHQ 261

  Fly   280 GAEGKYVWSLKGL--KETDISKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLS 342
            |::  |||:.:.|  |..|.|.| ||:|||:.....:...|...    .:|||.||||||:.:||
  Rat   262 GSQ--YVWNRQELIQKSLDPSVT-YLMGLFEPVDTKFEIQRDPL----MDPSLKDMTEAALHVLS 319

  Fly   343 KNEEGYFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSIN 407
            :|.:|::||||.||||..||...|..||.:...|.:|:|.|.::|.|:|||.:||:||||..|..
  Rat   320 RNPKGFYLFVEGGRIDRGHHLGTAYLALTEAVMFDSAIERASQLTSEQDTLTIVTADHSHVFSFG 384

  Fly   408 GYPYRRQNILSLAPNLADDELPFTILSYANGPGFDDTYSTKDGRIDLSHADTTSAEFEFQATVPL 472
            ||..|..:|..|||..|.|..|:|.:.|.||||:..|    ..|.:::.|::....::.||.||:
  Rat   385 GYTLRGTSIFGLAPLNALDGKPYTSILYGNGPGYVGT----GERPNVTDAESHDPSYQQQAAVPV 445

  Fly   473 SSETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAANIGPF 516
            .|||||.|||.:||.||..||..|..||:.|..:||:|..:.|:
  Rat   446 KSETHGGEDVAIFARGPQAHLLHGVQEQNYIAHVMAFAGCLEPY 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	201/468 (43%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	194/448 (43%)
Akp3	NP_073171.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351420
Domainoid	1	1.000	373	1.000	Domainoid score	I856
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	387	1.000	Inparanoid score	I1947
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8918
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910