DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp10 and phu

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_649897.4	Gene:	phu / 41135	FlyBaseID:	FBgn0043791	Length:	546	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	240/529 - (45%)
Similarity:	314/529 - (59%)	Gaps:	35/529 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 FFALLVIQARSDLADDQEHAQHP------------------RLQSSRDFEAL-DEELDTRFWHDK 55
            |..|.|:.:..:.:.|.|...||                  |......|:|: .||....:|...
  Fly     8 FLGLSVLVSGGESSHDAERRMHPVFSLMGTGSNPIGGGRYKRAMPQIVFDAVRSEERYAEYWQGL 72

  Fly    56 AQSILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGDSNKQVFFEKFPYLGLSKTYA 120
            |...|..:|....:||...|:||:||:|||||:.||.|.|.::|...||..||:|||:||||||.
  Fly    73 AAQTLDQQLESKLRLNTQLARNVMLFIGDGMSIPTITAGRVYLGGEEKQFAFEQFPYVGLSKTYC 137

  Fly   121 VNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSS--HVQSIGQWAQEAGKWAGLVT 183
            .|.:..|||.||||||.|||||||||||:|.||..||...:.:  ||.||..|||:.|...||||
  Fly   138 ANMQVADSACTATAYLGGVKANYGTIGVSAAVQFKDCQAQAQAAHHVSSIAAWAQKQGMATGLVT 202

  Fly   184 TARVTHASPAGVYAHVSERNWEHDGEIISSKCSPDVNTDIARQLVEWPVGQELRVIMGGGRSYFR 248
            |..||||||||||||::.||||:|.|::.....||:..|.|.||:..||||:|.|||||||..|.
  Fly   203 TTSVTHASPAGVYAHLANRNWENDAEVVGDNGDPDLCPDAAAQLINSPVGQKLNVIMGGGRENFL 267

  Fly   249 DQSQHDETGVSGLRTDGRDLISDWREIKKQQGAEGKYVWSLKGLKETDISKTDYLLGLFDTSHLP 313
            .:...|.:|..|.|.|||:||.:|   |.|.....:||.:.:.|.... :.|..:||||...|:.
  Fly   268 PKGVTDSSGAPGRRLDGRNLIDEW---KNQHTNSAQYVENRRELLNLS-NHTSRVLGLFAPYHMA 328

  Fly   314 YHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNE--EGYFLFVESGRIDMAHHATKAMKALEDTEEF 376
            ||.|.....    :|:|.:|.::|:::|.:..  .|||||||.||||..||.|.|::|:::|.||
  Fly   329 YHLDASPAE----QPTLEEMVQSAMEILERQSAGRGYFLFVEGGRIDHGHHDTLALRAIDETAEF 389

  Fly   377 AAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNILSLAP-NLADDELPFTILSYANGPG 440
            ..||..||..|..:||||||:||||||||:.||..|:.:|..:.. .||.|:||:..||||||||
  Fly   390 DKAVRFARSHTSTDDTLIVVSSDHSHTMSLAGYSSRKNDIFGINDGQLAADDLPYATLSYANGPG 454

  Fly   441 FDDTYSTKDG---RIDLSHADTTSAEFEFQATVPLSSETHGAEDVGVFASGPFEHLFTGNYEQSA 502
            :|..|..:.|   |.:|...:..:.:|.|.:||||.|||||.:||.||||||:..||||.:||..
  Fly   455 YDSNYLREGGAVRRKNLRAINMKNKDFMFPSTVPLESETHGGDDVAVFASGPYAQLFTGVFEQHF 519

  Fly   503 IPAMMAYAA 511
            ||..:.||:
  Fly   520 IPHALGYAS 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	225/461 (49%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	221/443 (50%)
phu	NP_649897.4	PhoA	71..524	CDD:224699	225/460 (49%)
phu	NP_649897.4	alkPPc	93..530	CDD:214515	221/444 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466625
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2001
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm6481
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	11	10.800