DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp10 and Alp8

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	487	Identity:	201/487 - (41%)
Similarity:	283/487 - (58%)	Gaps:	36/487 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 EELDTRFWHDKAQSILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGD------SNK 103
            ||:|.::|::.|...:..:|. ..:.|..:|||:|:||||||.:.|:||.|...|.      ...
  Fly    58 EEMDPQYWYNIADEEITKRLQ-LPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEES 121

  Fly   104 QVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNS--SSHVQ 166
            .:.||:|||.|||:||..|.:.||||.||||||.|||.|...|||:|.|:..:|..:.  ::.:.
  Fly   122 SLSFERFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLT 186

  Fly   167 SIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSKCSPDVNTDIARQLVEWP 231
            ||.:|||.|||..|:|||..:|||||:|.||..:.|.||.|.::.|.....:...|:|.|||...
  Fly   187 SIAEWAQNAGKSTGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQT 251

  Fly   232 VGQELRVIMGGGRSYFRDQSQHDETGVSGLRTDGRDLISDWREIKKQQGAE--GKYVWSLKGLKE 294
            .|:...|:.|||...|...|..|..|..|.|:||.:|:|.|      ||..  |..|.:...|.:
  Fly   252 PGKNFEVMFGGGMGKFLPNSIVDSHGNPGERSDGVNLLSRW------QGLHDGGVLVTNRNQLLK 310

  Fly   295 TDISKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNEE-GYFLFVESGRID 358
            .::|....::|||.:..:.:|.:...|:    :|:||::||..||.||:|:| |||.|:|.|.||
  Fly   311 LNVSAVSSVIGLFQSKLMNFHLEADDTY----QPTLSELTEVTIKKLSQNKEHGYFAFIEGGLID 371

  Fly   359 MAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNILSLAPNL 423
            ..:|.|||..||::..||..|::|||.|||.||||||||:||.|.:||.|||.|...||.:..:.
  Fly   372 YGNHYTKAGYALDEALEFEKAIQLARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHD 436

  Fly   424 AD-DELPFTILSYANGPGFDDTYSTKDGR---ID--LSHADTTSAEFEFQATVPLSSETHGAEDV 482
            .| :.:.:::|:||.||   :.|..::|:   :|  |...|..:..:     :|.....|..|||
  Fly   437 TDINGVQYSVLNYAAGP---NQYLDENGQRIPLDDILGSDDAITPSY-----IPKDQGVHSGEDV 493

  Fly   483 GVFASGPFEHLFTGNYEQSAIPAMMAYAANIG 514
            |:|||||..|||||..:||.||.:|||||.||
  Fly   494 GIFASGPQSHLFTGVMQQSTIPHLMAYAACIG 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	192/470 (41%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	190/452 (42%)
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	191/454 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466658
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900