DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp10 and Alp7

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_611653.1	Gene:	Alp7 / 37538	FlyBaseID:	FBgn0034710	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	207/548 - (37%)
Similarity:	297/548 - (54%)	Gaps:	62/548 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LILCFFALLVIQARSDLADDQEHAQHPRLQ---------SSRDFEALD------------EELDT 49
            |:||......:.|..|:.:     .|.:.|         .:|:...:|            ||.:.
  Fly     9 LVLCTLVATSLAASIDMPE-----IHNQFQLVGGSVSTAKTREGNLIDPNAMAKGKPGPEEEKNA 68

  Fly    50 RFWHDKAQSILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGD------SNKQVFFE 108
            :||:|.|...:|.:|. ..:|::.:|||||||||||||:.|:||.|...|.      ....:.||
  Fly    69 QFWYDLAYEEIAKRLE-QPQLDKRKAKNVILFLGDGMSLSTVAAARIHKGQLKGNTGEEDSLSFE 132

  Fly   109 KFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDC--VTNSSSHVQSIGQW 171
            ||||.|||:||..|.:.||||.||||||.|||.|...:|:.|.|...:|  ..:.::.|.||..|
  Fly   133 KFPYTGLSRTYCSNAQVPDSACTATAYLCGVKTNIVALGITAAVSFNNCSGSEDPANQVDSIAAW 197

  Fly   172 AQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIIS---SKCSPDVNTDIARQLVEWPVG 233
            ||.|||..|:|||..:|||||:|.||..:.|.:|.|.:|::   .:..|...||||.||:....|
  Fly   198 AQAAGKATGIVTTTTLTHASPSGAYAKTTNRFFESDTDILTYGEGQNDPATCTDIATQLITQAPG 262

  Fly   234 QELRVIMGGGRSYFRDQSQHDETGVSGLRTDGRDLISDWREIKKQQGAE--GKYVWSLKGLKETD 296
            :...|::|||...|...:..|.....|.|:||.:|:|.|      ||..  |...::...|...:
  Fly   263 KNFDVMLGGGIGKFLPNTITDPFNKKGERSDGVNLLSRW------QGLHPGGVLAYNRNQLLSVN 321

  Fly   297 ISKTDYLLGLFDTSHLPYH--GDRRRTHYEDAEPSLSDMTEAAIKMLSKNEEGYFLFVESGRIDM 359
            :||...|:|.|.:..:.::  .|.:.      ||:|::||..||:::||.:.|||||||.|.||.
  Fly   322 VSKITNLIGTFRSGVMSFNKMADPKE------EPTLAEMTRKAIEVVSKRDGGYFLFVEGGLIDY 380

  Fly   360 AHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNILSLAPNLA 424
            .:|......:|.:|.:|..||:.|..:||.|:|||||||||:|.::|:|||.|...||.|..:..
  Fly   381 GNHFNSPTYSLSETLQFEQAVQEALDITDPEETLIVVTSDHAHPLTISGYPGRGTPILGLNQDDT 445

  Fly   425 D-DELPFTILSYANGPGFDDTYSTKDG-RIDLSHADTTSAE-FEFQATVPLSSETHGAEDVGVFA 486
            | :.:.:..|:||.|   .:.|..:.| ||||:  |...|| |...:.:..:...|..:|||:||
  Fly   446 DVNGVKYATLNYAVG---TNQYLDEHGQRIDLT--DQIGAEDFIHPSYIHGTIGVHAGDDVGIFA 505

  Fly   487 SGPFEHLFTGNYEQSAIPAMMAYAANIG 514
            :||..|||||..:||.||.:||||:.||
  Fly   506 TGPQSHLFTGVMQQSTIPHLMAYASCIG 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	189/471 (40%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	186/453 (41%)
Alp7	NP_611653.1	ALP_like	94..533	CDD:304875	186/455 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466640
Domainoid	1	1.000	363	1.000	Domainoid score	I896
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900