DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp10 and SPBC14F5.13c

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_596739.1	Gene:	SPBC14F5.13c / 2539926	PomBaseID:	SPBC14F5.13c	Length:	532	Species:	Schizosaccharomyces pombe

Alignment Length:	503	Identity:	131/503 - (26%)
Similarity:	209/503 - (41%)	Gaps:	112/503 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 AGHKKLNEN-RAKNVILFLGDGMSVHTIAATRAFMGDSNKQVFFEKFP----YLGLSKTYAVNER 124
            :.||....| :.|.||:.:.|||...:::.||:|:...|.:..: :.|    .:|.|:|.:.:..
pombe    48 SSHKSKGTNEKPKFVIMMVSDGMGPGSLSMTRSFVETLNDKEGY-RLPLDEHLIGSSRTRSSSSL 111

  Fly   125 TPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSSHVQSIGQWAQEAGKWAGLVTTARVTH 189
            ..|||..|||:....|...|.:|          |.::.....:|.:.|:|||...|:|.|:|||.
pombe   112 ITDSAAGATAFSCANKTYNGAVG----------VLDNEKPCGTILEAAKEAGYLTGIVVTSRVTD 166

  Fly   190 ASPAGVYAHVSERNWEHDGEIISSKCSPDVNTDIARQLVEWPVGQELRVIMGGGRSYFRDQSQHD 254
            |:||...||.:.|..:   ::|:.           .|:...|:|:.:.::.|||...|..:|.:
pombe   167 ATPASFSAHAANRFMQ---DLIAE-----------YQVGMGPLGRSVDLLFGGGLCSFLPKSTY- 216

  Fly   255 ETGVSGLRTDGRDLISDWREIKKQQGAEGKYVWSLKGLKETDISKTDY---------LLGLFDTS 310
                ...|:|..||:              ||....:|. :..:::||:         |||||...
pombe   217 ----RSCRSDNLDLL--------------KYARKKEGF-QILLNRTDFDELSNAQLPLLGLFSDY 262

  Fly   311 HLPYHGDRRRTHYEDAEPSLSDMTEAAIKML--SKNEE---GYFLFVESGRIDMAHHATKAMKAL 370
            ||.|..|    :..:.:|.||:|.|.|:.:|  :.||:   |:||.:|..|||||.|....:..:
pombe   263 HLSYDID----YQPEVQPKLSEMVETALDVLLNATNEDTSKGFFLLIEGSRIDMASHNNDPIAHV 323

  Fly   371 EDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQ------------NILSLA--- 420
            .:..|:..|.|:|....::....::.||||    ...|....||            .:||||
pombe   324 YEVMEYNRAFEIASAFVEKNGGSLISTSDH----ETGGLTVGRQVSKKYPEYLWKPQVLSLALHS 384

  Fly   421 -----------------PNLADDELPFTILSYANGPGFDDTYSTKDGRIDLSH--ADTTSAEFEF 466
                             |.:....||...:...|.....|.|..:....:|.:  :|..|.|
pombe   385 IEYLASAIVNHNQNTLLPYIEQFVLPAIGIPDPNPKQIHDIYVARHNIFNLINVLSDIVSVE--- 446

  Fly   467 QATVPLSSETHGAEDVGVFASGPF-EHLFTGNYEQSAIPAMMAYAANI 513
             |.:..::..|.|.||.|:..|.. ||| .||.|...|...|....|:
pombe   447 -AQIGWTTHGHTAVDVNVYGVGEVTEHL-RGNMENIEIGQFMEIYLNV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	130/498 (26%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	127/488 (26%)
SPBC14F5.13c	NP_596739.1	PhoA	3..495	CDD:224699	131/503 (26%)
SPBC14F5.13c	NP_596739.1	ALP_like	60..487	CDD:304875	126/484 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	124	1.000	Domainoid score	I1405
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	124	1.000	Inparanoid score	I1462
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm46986
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
TreeFam	0	0.000	Not matched by this tool.
	10	9.860