Protein Alignment Alp10 and ALPG

DIOPT Version :10

• Sequence 1: NP_647976.1
• Gene: Alp10 / 38632
• FlyBaseID: FBgn0035619
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_112603.2
• Gene: ALPG / 251
• HGNCID: 441
• Length: 532
• Species: Homo sapiens
• Alignment Length: 503
• Identity: 214/503 - (42%)
• Similarity: 292/503 - (58%)
• Gaps: 44/503 - (8%)

  Fly    33 RLQSSRDFEALDEELDTRFWHDKAQSILADKLAGHKKLN--ENRAKNVILFLGDGMSVHTIAATR 95
            |||.|.....::|| :..||:.:|    |:.|...|||.  :..|||:|:||||||.|.|:.|.|
Human    13 RLQLSLGIIPVEEE-NPDFWNRQA----AEALGAAKKLQPAQTAAKNLIIFLGDGMGVSTVTAAR 72

  Fly    96 AFMGDSNKQ------VFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQR 154
            ...|....:      :..::|||:.|||||:|::..|||..||||||.|||.|:.|||::|..:.
Human    73 ILKGQKKDKLGPETFLAMDRFPYVALSKTYSVDKHVPDSGATATAYLCGVKGNFQTIGLSAAARF 137

  Fly   155 GDCVTNSSSHVQSIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSK----C 215
            ..|.|...:.|.|:...|::|||..|:|||.||.||||||.|||...|||..|.::.:|.    |
Human   138 NQCNTTRGNEVISVMNRAKKAGKSVGVVTTTRVQHASPAGAYAHTVNRNWYSDADVPASARQEGC 202

  Fly   216 SPDVNTDIARQLVEWPVGQELRVIMGGGRSYF-----RDQSQHDETGVSGLRTDGRDLISDWREI 275
            .     |||.||:.   ..::.||:||||.|.     .|....|:....|.|.||::|:.:|  :
Human   203 Q-----DIATQLIS---NMDIDVILGGGRKYMFPMGTPDPEYPDDYSQGGTRLDGKNLVQEW--L 257

  Fly   276 KKQQGAEGKYVWSLKGLKETDIS-KTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIK 339
            .|.|||  :|||:...|.:..:. ...:|:|||:...:.|...|..|    .:|||.:|||||:.
Human   258 AKHQGA--RYVWNRTELLQASLDPSVTHLMGLFEPGDMKYEIHRDST----LDPSLMEMTEAALL 316

  Fly   340 MLSKNEEGYFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTM 404
            :||:|..|:|||||.||||..||.::|.:||.:|..|..|:|.|.::|.|||||.:||:||||..
Human   317 LLSRNPRGFFLFVEGGRIDHGHHESRAYRALTETIMFDDAIERAGQLTSEEDTLSLVTADHSHVF 381

  Fly   405 SINGYPYRRQNILSLAPNLADDELPFTILSYANGPGFDDTYSTKDG-RIDLSHADTTSAEFEFQA 468
            |..|||.|..:|..|||..|.|...:|:|.|.||||    |..||| |.|::.:::.|.|:..|:
Human   382 SFGGYPLRGSSIFGLAPGKARDRKAYTVLLYGNGPG----YVLKDGARPDVTESESGSPEYRQQS 442

  Fly   469 TVPLSSETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAANIGPF 516
            .|||..|||..|||.|||.||..||..|..||:.|..:||:||.:.|:
Human   443 AVPLDGETHAGEDVAVFARGPQAHLVHGVQEQTFIAHVMAFAACLEPY 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	ALP_like	76..514	CDD:474031	198/454 (44%)
ALPG	NP_112603.2	Alk_phosphatase	52..487	CDD:395188	199/454 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..443		7/20 (35%)