DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp10 and ALPL

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_000469.3	Gene:	ALPL / 249	HGNCID:	438	Length:	524	Species:	Homo sapiens

Alignment Length:	488	Identity:	211/488 - (43%)
Similarity:	283/488 - (57%)	Gaps:	34/488 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DEELDTRFWHDKAQSILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGD------SN 102
            ::|.|.::|.|:||..|...|. .:|||.|.|||||:||||||.|.|:.|.|...|.      ..
Human    21 EKEKDPKYWRDQAQETLKYALE-LQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEE 84

  Fly   103 KQVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSSHVQS 167
            .::..:|||::.|||||..|.:.||||.||||||.|||||.||:||:|..:|..|.|...:.|.|
Human    85 TRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTS 149

  Fly   168 IGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEI----ISSKCSPDVNTDIARQLV 228
            |.:||::|||..|:|||.||.||:|:..|||.::|:|..|.|:    :|..|.     |||.||:
Human   150 ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCK-----DIAYQLM 209

  Fly   229 EWPVGQELRVIMGGGRSYFRDQSQHD-----ETGVSGLRTDGRDLISDWREIKKQQGAEGKYVWS 288
            .  ..:::.|||||||.|...:::.|     :....|.|.||.||:..|:..|.:. ....::|:
Human   210 H--NIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRY-KHSHFIWN 271

  Fly   289 LKGLKETDISKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNEEGYFLFVE 353
            ...|...|....|||||||:...:.|..:|...    .:||||:|...||::|.||.:|:||.||
Human   272 RTELLTLDPHNVDYLLGLFEPGDMQYELNRNNV----TDPSLSEMVVVAIQILRKNPKGFFLLVE 332

  Fly   354 SGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNILS 418
            .||||..||..||.:||.:..|...|:..|..:|..||||.|||:||||..:..||..|..:|..
Human   333 GGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFG 397

  Fly   419 LAPNLAD-DELPFTILSYANGPGFDDTYSTKDG-RIDLSHADTTSAEFEFQATVPLSSETHGAED 481
            |||.|:| |:.|||.:.|.||||    |....| |.::|..|.....::.|:.|||..||||.||
Human   398 LAPMLSDTDKKPFTAILYGNGPG----YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGED 458

  Fly   482 VGVFASGPFEHLFTGNYEQSAIPAMMAYAANIG 514
            |.||:.||..||..|.:||:.:|.:|||||.||
Human   459 VAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	202/470 (43%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	195/452 (43%)
ALPL	NP_000469.3	Alk_phosphatase	51..490	CDD:333956	197/454 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157450
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.810