DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp10 and ALPI

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001622.2	Gene:	ALPI / 248	HGNCID:	437	Length:	528	Species:	Homo sapiens

Alignment Length:	503	Identity:	215/503 - (42%)
Similarity:	294/503 - (58%)	Gaps:	44/503 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 RLQSSRDFEALDEELDTRFWHDKAQSILADKLAGHKKLN--ENRAKNVILFLGDGMSVHTIAATR 95
            |||.|......:|| :..||:.:|    |:.|...|||.  :..|||:|||||||:.|.|:.|||
Human    13 RLQLSLGVIPAEEE-NPAFWNRQA----AEALDAAKKLQPIQKVAKNLILFLGDGLGVPTVTATR 72

  Fly    96 AFMGDSNKQ------VFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQR 154
            ...|..|.:      :..::||||.|||||.|:.:.||||.||||||.|||||:.|||::|..:.
Human    73 ILKGQKNGKLGPETPLAMDRFPYLALSKTYNVDRQVPDSAATATAYLCGVKANFQTIGLSAAARF 137

  Fly   155 GDCVTNSSSHVQSIGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEIISSK----C 215
            ..|.|...:.|.|:...|::|||..|:|||.||.||||||.|||...|||..|.::.:|.    |
Human   138 NQCNTTRGNEVISVMNRAKQAGKSVGVVTTTRVQHASPAGTYAHTVNRNWYSDADMPASARQEGC 202

  Fly   216 SPDVNTDIARQLVEWPVGQELRVIMGGGRSYFRDQSQHD-----ETGVSGLRTDGRDLISDWREI 275
            .     |||.||:.   ..::.||:||||.|.......|     :...:|:|.||::|:.:|  :
Human   203 Q-----DIATQLIS---NMDIDVILGGGRKYMFPMGTPDPEYPADASQNGIRLDGKNLVQEW--L 257

  Fly   276 KKQQGAEGKYVWSLKGLKETDISKT-DYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIK 339
            .|.|||  .|||:...|.:..:.:: .:|:|||:.....|...|..|    .:|||.:|||||::
Human   258 AKHQGA--WYVWNRTELMQASLDQSVTHLMGLFEPGDTKYEIHRDPT----LDPSLMEMTEAALR 316

  Fly   340 MLSKNEEGYFLFVESGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTM 404
            :||:|..|::||||.||||..||...|.:||.:...|..|:|.|.::|.|||||.:||:||||..
Human   317 LLSRNPRGFYLFVEGGRIDHGHHEGVAYQALTEAVMFDDAIERAGQLTSEEDTLTLVTADHSHVF 381

  Fly   405 SINGYPYRRQNILSLAPNLADDELPFTILSYANGPGFDDTYSTKDG-RIDLSHADTTSAEFEFQA 468
            |..||..|..:|..|||:.|.|...:|.:.|.||||    |....| |.|::.:::.|.:::.||
Human   382 SFGGYTLRGSSIFGLAPSKAQDSKAYTSILYGNGPG----YVFNSGVRPDVNESESGSPDYQQQA 442

  Fly   469 TVPLSSETHGAEDVGVFASGPFEHLFTGNYEQSAIPAMMAYAANIGPF 516
            .|||||||||.|||.|||.||..||..|..|||.:..:||:||.:.|:
Human   443 AVPLSSETHGGEDVAVFARGPQAHLVHGVQEQSFVAHVMAFAACLEPY 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	204/472 (43%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	198/452 (44%)
ALPI	NP_001622.2	Alk_phosphatase	52..487	CDD:306706	200/454 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157463
Domainoid	1	1.000	366	1.000	Domainoid score	I927
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2088
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8441
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.810