DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alp10 and Alpl

DIOPT Version :9

Sequence 1:	NP_647976.1	Gene:	Alp10 / 38632	FlyBaseID:	FBgn0035619	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001274101.1	Gene:	Alpl / 11647	MGIID:	87983	Length:	524	Species:	Mus musculus

Alignment Length:	488	Identity:	216/488 - (44%)
Similarity:	289/488 - (59%)	Gaps:	34/488 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DEELDTRFWHDKAQSILADKLAGHKKLNENRAKNVILFLGDGMSVHTIAATRAFMGD------SN 102
            ::|.|..:|..:||..|.:.|. .:|||.|.|||||:||||||.|.|:.|.|...|.      ..
Mouse    21 EKERDPSYWRQQAQETLKNALK-LQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNTGEE 84

  Fly   103 KQVFFEKFPYLGLSKTYAVNERTPDSANTATAYLTGVKANYGTIGVNAQVQRGDCVTNSSSHVQS 167
            .::..:|||::.|||||..|.:.||||.||||||.|||||.||:||:|..:|..|.|...:.|.|
Mouse    85 TRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERTRCNTTQGNEVTS 149

  Fly   168 IGQWAQEAGKWAGLVTTARVTHASPAGVYAHVSERNWEHDGEI----ISSKCSPDVNTDIARQLV 228
            |.:||::|||..|:|||.||.||:|:..|||.::|:|..|.|:    :|..|.     |||.||:
Mouse   150 ILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCK-----DIAYQLM 209

  Fly   229 EWPVGQELRVIMGGGRSYFRDQSQHD-----ETGVSGLRTDGRDLISDWREIKKQQGAEGKYVWS 288
            .  ..:::.|||||||.|...:::.|     :....|.|.||.||||.|:..|.:. ....|||:
Mouse   210 H--NIKDIDVIMGGGRKYMYPKNRTDVEYELDEKARGTRLDGLDLISIWKSFKPRH-KHSHYVWN 271

  Fly   289 LKGLKETDISKTDYLLGLFDTSHLPYHGDRRRTHYEDAEPSLSDMTEAAIKMLSKNEEGYFLFVE 353
            ...|...|.|:.|||||||:...:.|..:|...    .:||||:|.|.|:::|:||.:|:||.||
Mouse   272 RTELLALDPSRVDYLLGLFEPGDMQYELNRNNL----TDPSLSEMVEVALRILTKNLKGFFLLVE 332

  Fly   354 SGRIDMAHHATKAMKALEDTEEFAAAVELARKMTDEEDTLIVVTSDHSHTMSINGYPYRRQNILS 418
            .||||..||..||.:||.:..|...|:..|..||.::|||.|||:||||..:..||..|..:|..
Mouse   333 GGRIDHGHHEGKAKQALHEAVEMDQAIGKAGAMTSQKDTLTVVTADHSHVFTFGGYTPRGNSIFG 397

  Fly   419 LAPNLAD-DELPFTILSYANGPGFDDTYSTKDG-RIDLSHADTTSAEFEFQATVPLSSETHGAED 481
            |||.::| |:.|||.:.|.||||    |...|| |.::|..|.....::.|:.|||..||||.||
Mouse   398 LAPMVSDTDKKPFTAILYGNGPG----YKVVDGERENVSMVDYAHNNYQAQSAVPLRHETHGGED 458

  Fly   482 VGVFASGPFEHLFTGNYEQSAIPAMMAYAANIG 514
            |.|||.||..||..|.:||:.||.:||||:.||
Mouse   459 VAVFAKGPMAHLLHGVHEQNYIPHVMAYASCIG 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp10	NP_647976.1	PhoA	56..510	CDD:224699	209/470 (44%)
Alp10	NP_647976.1	ALP_like	75..511	CDD:304875	202/452 (45%)
Alpl	NP_001274101.1	Alk_phosphatase	51..490	CDD:333956	203/454 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847882
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8682
orthoMCL	1	0.900	-	-		OOG6_100381
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.810